Ets2^tm3.1Rgo
Targeted Allele Detail

Summary

• Symbol: Ets2^tm3.1Rgo
• Name: E26 avian leukemia oncogene 2, 3' domain; targeted mutation 3.1, Robert G Oshima
• MGI ID: MGI:3614480
• Synonyms: Ets2^db2
• Gene: Ets2 Location: Chr16:95503274-95522093 bp, + strand Genetic Position: Chr16, 56.64 cM, cytoband C3-qter
• Alliance: Ets2^tm3.1Rgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102368
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The exons 9 and 10, encoding the C-terminal portion of the DNA-binding domain and flanked by loxP sites, were removed after crossing with mice expressing cre in an epiblast-restricted manner allowing targeted recombination in all adult tissues. PCR showed that less than 10-15% of the functional Ets2^tm3Rgo allele remained in adult tissues. Mammary tissue was nearly completely recombined. (J:102368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ets2 Mutation: 37 strains or lines available

References

• Original: J:102368 Tynan JA, et al., Ets2-dependent microenvironmental support of mouse mammary tumors. Oncogene. 2005 Oct 20;24(46):6870-6
• All: 1 reference(s)