Pak4^tm2.1Amin
Targeted Allele Detail

Summary

• Symbol: Pak4^tm2.1Amin
• Name: p21 (RAC1) activated kinase 4; targeted mutation 2.1, Audrey Minden
• MGI ID: MGI:4360333
• Synonyms: Pak4^f
• Gene: Pak4 Location: Chr7:28258244-28297609 bp, - strand Genetic Position: Chr7, 16.84 cM
• Alliance: Pak4^tm2.1Amin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152821
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 4. Germ line, cre mediated recombination removed the neo cassette leaving exons 2 through 4 floxed. (J:152821)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pak4 Mutation: 91 strains or lines available

References

• Original: J:152821 Tian Y, et al., Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev. 2009 Aug-Sep;126(8-9):710-20
• All: 7 reference(s)