Pcsk5^tm2.1Prat
Targeted Allele Detail

Summary

• Symbol: Pcsk5^tm2.1Prat
• Name: proprotein convertase subtilisin/kexin type 5; targeted mutation 2.1, Annik Prat
• MGI ID: MGI:3789184
• Synonyms: Pcsk5^delta1
• Gene: Pcsk5 Location: Chr19:17409683-17814996 bp, - strand Genetic Position: Chr19, 12.86 cM
• Alliance: Pcsk5^tm2.1Prat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134264
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Germ-line, cre-mediated recombination was used to remove exon 1. (J:134264)

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcsk5 Mutation: 95 strains or lines available

References

• Original: J:134264 Essalmani R, et al., In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5750-5
• All: 4 reference(s)