Procr^tm3Cte
Targeted Allele Detail

Summary

• Symbol: Procr^tm3Cte
• Name: protein C receptor, endothelial; targeted mutation 3, Charles T Esmon
• MGI ID: MGI:3831362
• Synonyms: Procr^s
• Gene: Procr Location: Chr2:155593037-155597391 bp, + strand Genetic Position: Chr2, 77.26 cM, cytoband H1-3
• Alliance: Procr^tm3Cte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144388
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A BclI site was introduced into exon 4 which replaced the codon for Leucine at residue 215 with a stop codon. The resulting protein is truncated above thre transmembrane domain. A floxed neomycin selection cassette was also inserted in intron 1. (J:144388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Procr Mutation: 15 strains or lines available

Notes

ES cell line = AB2.

References

• Original: J:144388 Zheng X, et al., Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. Blood. 2007 Feb 1;109(3):1003-9
• All: 2 reference(s)