Ern1^tm2.1Tiw
Targeted Allele Detail

Summary

• Symbol: Ern1^tm2.1Tiw
• Name: endoplasmic reticulum to nucleus signalling 1; targeted mutation 2.1, Takao Iwawaki
• MGI ID: MGI:4365397
• Synonyms: Ern1fl, IRE1alpha^deltaNeo
• Gene: Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
• Alliance: Ern1^tm2.1Tiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153222
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 20 and a frt flanked neo cassette and second loxP site were inserted downstream of exon 21 via homologous recombination. The neo cassette was then removed via Flp mediated recombination. (J:153222)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ern1 Mutation: 57 strains or lines available

References

• Original: J:153222 Iwawaki T, et al., Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
• All: 42 reference(s)