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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ern1tm2.1Tiw
targeted mutation 2.1, Takao Iwawaki
MGI:4365397
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ern1tm2.1Tiw/Ern1tm2.1Tiw
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * SJL MGI:5559520
cn2
 		Ern1tm2.1Tiw/Ern1tm2.2Tiw
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJae * C57BL/6 MGI:4365404


Genotype
MGI:5559520
cn1
Allelic
Composition		 Ern1tm2.1Tiw/Ern1tm2.1Tiw
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern1tm2.1Tiw mutation (1 available); any Ern1 mutation (58 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Xbp1tm2Glm mutation (0 available); any Xbp1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:206084 )
• enteritis is diminished compared to mice with IEC (intestinal epithelial cell) deletion of Xbp1 only

digestive/alimentary system
small intestinal inflammation ( J:206084 )
• enteritis is diminished compared to mice with IEC (intestinal epithelial cell) deletion of Xbp1 only




Genotype
MGI:4365404
cn2
Allelic
Composition		 Ern1tm2.1Tiw/Ern1tm2.2Tiw
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern1tm2.1Tiw mutation (1 available); any Ern1 mutation (58 available)
Ern1tm2.2Tiw mutation (0 available); any Ern1 mutation (58 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:153222 )
N
• unlike germline null mice, no placental abnormalities are seen

liver/biliary system
liver/biliary system phenotype ( J:153222 )
N
• unlike germline null mice, no liver hypoplasia is seen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory