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All mouse models of amyotrophic lateral sclerosis with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | amyotrophic lateral sclerosis type 1 | Sod1m1H/Sod1m1H | involves: C3H/HeH * C57BL/6J | J:219360 | View | |||
| amyotrophic lateral sclerosis type 1 | Tg(Sod1*G86R)M1Jwg/0 | involves: FVB/N | J:22628, J:58733, J:91800 | View | ||||
| amyotrophic lateral sclerosis type 4 | Setxtm1.1Als/Setx+ | involves: C57BL/6J | J:320844 | View | ||||
| amyotrophic lateral sclerosis type 6 | Fustm1.1Emcf/Fus+ | involves: C3H * C57BL/6J * C57BL/6N | J:249965 | View | ||||
| amyotrophic lateral sclerosis type 10 |
Mnx1tm4(cre)Tmj/Mnx1+ Tardbptm1.1Ckjs/Tardbptm1.2Cjks |
involves: 129S1/Sv * C57BL/6J | J:190254 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tardbpem1Rhbr/Tardbpem1Rhbr | C57BL/6J-Tardbpem1Rhbr | J:261673 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tardbptm1.1Neas/Tardbptm1.1Neas | B6(C3)-Tardbptm1.1Neas | J:283769 | View | ||||
| amyotrophic lateral sclerosis type 10 |
Tardbptm1.1Sobue/Tardbptm1.1Sobue Tg(SLC18A3-cre)Misa/0 |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NTac | J:324570 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tardbptm2.1Neas/Tardbptm2.1Neas | B6(C3)-Tardbptm2.1Neas | J:283769 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tardbptm3.1Ckjs/Tardbp+ | involves: C57BL/6J | J:285792 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(CAG-dsRed2/RNAi:Tardbp)6Zxu/0 | involves: C57BL/6 * C57BL/6J * FVB/NJ * SJL | J:207750 | View | ||||
| amyotrophic lateral sclerosis type 21 | Matr3em1Tcp/Matr3em1Tcp | C57BL/6J-Matr3em1Tcp | J:298091 | View | ||||
| | amyotrophic lateral sclerosis |
Adarb1tm1.1Skwa/Adarb1tm1.1Skwa Tg(SLC18A3-cre)KMisa/0 |
involves: C57BL/6 | J:164294 | View | |||
| amyotrophic lateral sclerosis | Epg5tm1Ygz/Epg5tm1Ygz | involves: 129S1/Sv * 129X1/SvJ * C57BL/6N | J:196603 | View | ||||
| amyotrophic lateral sclerosis |
Psmc4tm1.1Ryot/Psmc4tm1.2Ryot Tg(SLC18A3-cre)KMisa/0 |
involves: C57BL/6 * C57BL/6N | J:193770 | View | ||||
| amyotrophic lateral sclerosis | Stmn2em1Jmi/Stmn2+ | C57BL/6N-Stmn2em1Jmi | J:337175 | View | ||||
| amyotrophic lateral sclerosis | Stmn2em1Jmi/Stmn2em1Jmi | C57BL/6N-Stmn2em1Jmi | J:337175 | View | ||||
| amyotrophic lateral sclerosis | Zfp106tm1b(KOMP)Wtsi/Zfp106tm1b(KOMP)Wtsi | involves: C57BL/6N | J:241305 | View | ||||
| amyotrophic lateral sclerosis type 1 | Sod2tm1Cje/Sod2tm1Cje | involves: C57BL/6J | J:45913 | View | ||||
| amyotrophic lateral sclerosis type 1 | Vegfatm2Pec/Vegfatm2Pec | involves: 129S1/Sv * 129X1/SvJ | J:69797 | View | ||||
| amyotrophic lateral sclerosis type 1 | Vps54wr/Vps54wr | involves: C57BL/6J * C57BL/Fa | J:181019, J:196432 | View | ||||
| Transgenes and Other Mutations | amyotrophic lateral sclerosis type 1 |
Cybbtm1Din/Y Tg(SOD1*G93A)dl1Gur/0 |
B6.Cg-Cybbtm1Din Tg(SOD1*G93A)dl1Gur | J:111782 | View | |||
| amyotrophic lateral sclerosis type 1 |
Isl1tm1(cre)Tmj/Isl1+ Tg(SOD1*G37R)1Dwc/0 |
involves: 129X1/SvJ * C57BL/6 | J:109131 | View | ||||
| amyotrophic lateral sclerosis type 1 |
Tg(ITGAM-cre)2781Gkl/0 Tg(SOD1*G37R)1Dwc/0 |
involves: C57BL/6 * CBA | J:109131 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(Myl1-SOD1*G93A)#Amu/0 | FVB/NJ-Tg(Myl1-SOD1*G93A)#Amu | J:143747 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(NEFH)200Jpj/0 | Not Specified | J:69180 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(NEFH)200Jpj/Tg(NEFH)200Jpj | Not Specified | J:69180 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(NFH)120Jpj/0 | Not Specified | J:69180 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(NFH)120Jpj/Tg(NFH)120Jpj | Not Specified | J:69180 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(Prnp-Immt/SOD1*G93A)7Gmnf/Tg(Prnp-Immt/SOD1*G93A)7Gmnf | involves: C57BL/6 * CBA * SJL | J:177846 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo/Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo | involves: C3H * C57BL/6 | J:104655 | View | ||||
| amyotrophic lateral sclerosis type 1 |
Tg(SOD1)2Gur/0 Tg(SOD1*)D-14Dbo/0 |
involves: C3H/HeJ * C57BL/6 * C57BL/6J * SJL | J:218091 | View | ||||
| amyotrophic lateral sclerosis type 1 |
Tg(SOD1)2Gur/0 Tg(SOD1*G85R)#Roos/0 |
involves: C57BL/6 * C57BL/6J * SJL | J:147156 | View | ||||
| amyotrophic lateral sclerosis type 1 |
Tg(SOD1)2Gur/0 Tg(SOD1*G93A)1Gur/0 |
involves: C57BL/6 * SJL | J:109458 | View | ||||
| amyotrophic lateral sclerosis type 1 |
Tg(SOD1)2Gur/0 Tg(SOD1*L126Z)#Deng/0 |
involves: C57BL/6 * SJL | J:109458 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*)125Dbo/? | involves: C3H/HeJ * C57BL/6J | J:86421 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*)D-14Dbo/0 | involves: C3H/HeJ * C57BL/6J | J:218091 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*)DF7Yaw/0 | C57BL/6-Tg(SOD1*)DF7Yaw | J:97932 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*)DF7Yaw/Tg(SOD1*)DF7Yaw | C57BL/6-Tg(SOD1*)DF7Yaw | J:97932 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G37R)9Dpr/0 | involves: C3H/HeJ * C57BL/6J | J:69178 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G37R)29Dpr/0 | involves: C3H/HeJ * C57BL/6J | J:69178, J:119631 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G37R)42Dpr/0 | involves: C3H/HeJ * C57BL/6J | J:69178 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G37R)106Dpr/0 | involves: C3H/HeJ * C57BL/6J | J:69178 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G85R)74Dwc/? | Not Specified | J:77600 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G85R)148Dwc/? | Not Specified | J:77600 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G85R)#Roos/0 | involves: C57BL/6J | J:147156 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G85R/EYFP)641Alho/Tg(SOD1*G85R/EYFP)641Alho | involves: C57BL/6J * SJL/J | J:144475 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G85R/EYFP)737Alho/Tg(SOD1*G85R/EYFP)737Alho | involves: C57BL/6J * SJL/J | J:212250 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G93A)1Gur/0 | B6.Cg-Tg(SOD1*G93A)1Gur | J:155140 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G93A)1Gur/0 | B6.Cg-Tg(SOD1*G93A)1Gur/J | J:211734 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G93A)1Gur/0 | B6SJL-Tg(SOD1*G93A)1Gur | J:144199 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G93A)1Gur/0 | B6SJL-Tg(SOD1*G93A)1Gur/J | J:133155, J:143173, J:146652, J:212250 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G93A)1Gur/0 | involves: C57BL/6 * SJL | J:76718, J:91800, J:109458, J:130581 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G93A)2Gur/0 | involves: C57BL/6 * SJL | J:32665, J:78629, J:89928 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G93A)dl1Gur/0 | involves: C57BL/6 * SJL | J:106420 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*G127X)716Mrkl/Tg(SOD1*G127X)716Mrkl | B6JBom.Cg-Tg(SOD1*G127X)716Mrkl | J:175594 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*H46R)#Maw/0 | involves: C57BL/6 * DBA/2 | J:99701 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*H46R)IAra/0 | involves: C57BL/6 * DBA/2 | J:221350 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*H46R)LAra/0 | involves: C57BL/6 * DBA/2 | J:221350 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*H46R*H48Q)58Dbo/0 | involves: C3H/HeJ * C57BL/6J | J:119631 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*H46R*H48Q)139Dbo/0 | involves: C3H/HeJ * C57BL/6J | J:119631 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*L126Z)45Dbo/0 | involves: C3H/HeJ * C57BL/6J | J:219482 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(SOD1*L126Z)#Deng/0 | involves: C57BL/6 * SJL | J:109458 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(Thy1-DCTN1*G59S)M2Pcw/? | involves: C57BL/6 * SJL | J:132857 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(Thy1-Sncg)HvP36Putt/? | C57BL/6-Tg(Thy1-Sncg)HvP36Putt | J:185793 | View | ||||
| amyotrophic lateral sclerosis type 1 |
Tg(Thy1-SOD1*G93A)T1Hgrd/0 Tg(Thy1-SOD1*G93A)T3Hgrd/0 |
involves: C57BL/6 * CBA * FVB | J:134095 | View | ||||
| amyotrophic lateral sclerosis type 1 | Tg(Thy1-SOD1*G93A)T3Hgrd/Tg(Thy1-SOD1*G93A)T3Hgrd | involves: C57BL/6 * CBA * FVB | J:134095 | View | ||||
| amyotrophic lateral sclerosis type 4 | Tg(Prnp-SETX*R2136H)1920Als/0 | involves: C57BL/6J | J:320844 | View | ||||
| amyotrophic lateral sclerosis type 6 |
Meox2tm1(cre)Sor/Meox2+ Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 |
involves: 129S4/SvJaeSor * C57BL/6 | J:216672 | View | ||||
| amyotrophic lateral sclerosis type 6 |
Meox2tm1(cre)Sor/Meox2+ Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 |
involves: 129S4/SvJaeSor * C57BL/6 | J:216672 | View | ||||
| amyotrophic lateral sclerosis type 6 | Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw | involves: C57BL/6 * Crl:CD-1(ICR) | J:189360 | View | ||||
| amyotrophic lateral sclerosis type 6 | Tg(Prnp-FUS*R521C)3313Ejh/0 | involves: C57BL/6 * SJL | J:209419 | View | ||||
| amyotrophic lateral sclerosis type 6 | Tg(Thy1-FUS*)1Dit/0 | B6.Cg-Tg(Thy1-FUS*)1Dit | J:287782, J:277077 | View | ||||
| amyotrophic lateral sclerosis type 6 | Tg(Thy1-FUS*)19Vlb/0 | B6.Cg-Tg(Thy1-FUS*)19Vlb | J:203550 | View | ||||
| amyotrophic lateral sclerosis type 8 | Tg(Thy1-VAPB*P56S,-EGFP)D3Cai/0 | C57BL/6-Tg(Thy1-VAPB*P56S,-EGFP)D3Cai | J:202148 | View | ||||
| amyotrophic lateral sclerosis type 10 |
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-TARDBP)12Vle/0 |
involves: C3H/HeJ * C57BL/6J | J:170756 | View | ||||
| amyotrophic lateral sclerosis type 10 |
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-TARDBP*)4Vle/0 |
involves: C3H/HeJ * C57BL/6J | J:170756 | View | ||||
| amyotrophic lateral sclerosis type 10 |
Tg(NEFH-tTA)8Vle/0 Tg(tetO-TARDBP*)4Vle/0 |
involves: C3H/HeJ * C57BL/6J | J:225639 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc | C57BL/6-Tg(Prnp-TARDBP)3cPtrc | J:163231 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Prnp-TARDBP)4Jlel/0 | involves: C57BL/6 * CD-1 * SJL | J:165985 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Prnp-TARDBP*A315T)23Jlel/0 | involves: C57BL/6 * CD-1 * SJL | J:165985 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Prnp-TARDBP*A315T)95Balo/0 | involves: C57BL/6 * CBA | J:153197 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Prnp-TARDBP*Q331K)103Dwc/0 | B6.Cg-Tg(Prnp-TARDBP*Q331K)103Dwc/J | J:242322 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(TARDBP)#Jpj/0 | involves: C3H * C57BL/6 | J:195184 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(TARDBP*A315T)#Jpj/0 | involves: C3H * C57BL/6 | J:195184 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(TARDBP*G348C)#Jpj/0 | involves: C3H * C57BL/6 | J:195184 | View | ||||
| amyotrophic lateral sclerosis type 10 |
Tg(tetO-TARDBP*A315T)13Lmit/0 Tg(Thy1-tTA)6Lmit/0 |
involves: C57BL/6 | J:245760, J:242322 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Thy1-TARDBP)4Singh/0 | involves: C57BL/6J * SJL/J | J:157550 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Thy1-TARDBP)4Singh/Tg(Thy1-TARDBP)4Singh | involves: C57BL/6J * SJL/J | J:157550 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Thy1-TARDBP)6Singh/Tg(Thy1-TARDBP)6Singh | involves: C57BL/6 * C57BL/6J * SJL | J:157550 | View | ||||
| amyotrophic lateral sclerosis type 10 | Tg(Thy1-TARDBP*)BOddo/Tg(Thy1-TARDBP*)BOddo | C57BL/6-Tg(Thy1-TARDBP*)BOddo | J:223932 | View | ||||
| amyotrophic lateral sclerosis type 15 | Tg(Thy1-UBQLN2*P497S)3Mont/? | involves: C3H * C57BL/6 * C57BL/6J | J:239510 | View | ||||
| amyotrophic lateral sclerosis type 15 | Tg(Thy1-UBQLN2*P506T)6Mont/? | involves: C3H * C57BL/6 * C57BL/6J | J:239510 | View | ||||
| frontotemporal dementia and/or amyotrophic lateral sclerosis 1 | Tg(C9orf72)500Lpwr/0 | FVB/NJ-Tg(C9orf72)500Lpwr | J:239579 | View | ||||
| Additional Complex Models | amyotrophic lateral sclerosis type 1 |
Tg(SOD1)2Gur/0 Tg(SOD1*A4V)A1073Gur/0 |
involves: C57BL/6 * SJL | J:109458 | View | |||
| amyotrophic lateral sclerosis type 10 |
Tg(Prnp-TARDBP)96Dwc/0 Tg(Prnp-TARDBP*Q331K)31Dwc/0 |
involves: C3H * C57BL/6 | J:239141 | View | ||||
| amyotrophic lateral sclerosis type 18 | Mdga2Tg(Prnp-PFN1*G118V)838Kiaei/Mdga2+ | involves: C57BL/6N | J:241428 | View | ||||
| amyotrophic lateral sclerosis type 18 |
Tg(Prnp-PFN1*C71G)22Zxu/0 Tg(Thy1-PFN1*C71G)67Zxu/Tg(Thy1-PFN1*C71G)67Zxu |
involves: FVB/N | J:235427 | View | ||||
| frontotemporal dementia and/or amyotrophic lateral sclerosis 7 | Atp2b1Tg(Thy1-CHMP2B*)1Rene/Atp2b1+ | involves: C57BL/6 * DBA/2 * FVB/N | J:237873 | View | ||||
| frontotemporal dementia and/or amyotrophic lateral sclerosis 7 | Atp2b1Tg(Thy1-CHMP2B*)1Rene/Atp2b1Tg(Thy1-CHMP2B*)1Rene | involves: C57BL/6 * DBA/2 * FVB/N | J:237873 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | amyotrophic lateral sclerosis type 2 | Als2tm1Cai/Als2tm1Cai | involves: 129X1/SvJ * C57BL/6J | J:100336 | View | |||
| amyotrophic lateral sclerosis type 2 | Als2tm1Garo/Als2tm1Garo | either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) | J:138147 | View | ||||
| amyotrophic lateral sclerosis type 2 | Als2tm1Jei/Als2tm1Jei | involves: 129P2/OlaHsd * C57BL/6J | J:104446 | View | ||||