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Transgene Detail
Symbol: Tg(NFH)120Jpj
Name: transgene insertion 120, Jean-Pierre Julien
MGI ID: MGI:2182067
Transgene: Tg(NFH)120Jpj  Location: unknown  
Alliance: Tg(NFH)120Jpj page
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(NFH)120Jpj expresses 1 gene
Mutation detailsThe complete human NFH gene including 9.6 kb of 5' sequences and 13.4 kb of 3' sequences was used for the transgene. Expression of the human gene in transgenic animals was confirmed by Western blot analysis. (J:69180)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Founder 120 is representative of 2 founders carrying 2 and 3 copies of the transgene. These animals express approximately 50% the amount of endogenous mRNA and exhibit neurological anomalies at 6 months of age.

The phenotype is more severe in homozygous mice verses hemizygous mice, implying a correlation between phenotype and expression levels of NEFH.

Original:  J:69180 Cote F, et al., Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell. 1993 Apr 9;73(1):35-46
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.23
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