Phenotypes Associated with This Genotype

Genotype
MGI:8401702

• Allelic Composition: Nek1^em1Hdt/Nek1⁺; Pml^em10Hdt/Pml^em10Hdt
• Genetic Background: FVB/N-Nek1^em1Hdt Pml^em10Hdt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:390648 )

• shortened lifespan, partial penetrance

growth/size/body

weight loss ( J:390648 )

• mice show significant weight loss beginning at 60-70 weeks of age

nervous system

abnormal nervous system morphology ( J:390648 )

• mice exhibit amyotrophic lateral sclerosis-like phenotypes, with mean onset of neurological symptoms at 31.5 weeks

behavior/neurological

impaired coordination ( J:390648 )

• impaired coordination and motor function starting at 31.5 weeks after birth on the hanging wire

decreased grip strength ( J:390648 )

• grip strength and limb clasping show an age-dependent, progressive decline in muscle strength and motor function

muscle

muscle weakness ( J:390648 )

• severe muscle weakness

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 24		DOID:0081378	OMIM:617892	J:390648