Pml^em10Hdt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pml^em10Hdt
• Name: promyelocytic leukemia; endonuclease-mediated mutation 10, Hugues de The
• MGI ID: MGI:8399326
• Gene: Pml Location: Chr9:58125359-58157069 bp, - strand Genetic Position: Chr9, 31.63 cM
• Alliance: Pml^em10Hdt page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas-mediated targeting removed exon 3. (J:390648)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pml Mutation: 94 strains or lines available

References

• Original: J:390648 Georgiadou, et al., Pml loss worsens NEK1-linked ALS and Pml induction drives NEK1 degradation, precluding disease onset. FEBS J. 2026
• All: 1 reference(s)