Nek1^em1Hdt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nek1^em1Hdt
• Name: NIMA (never in mitosis gene a)-related expressed kinase 1; endonuclease-mediated mutation 1, Hugues de The
• MGI ID: MGI:8398103
• Synonyms: Nek1-Lys764Ter, Nek1^t
• Gene: Nek1 Location: Chr8:61446229-61584380 bp, + strand Genetic Position: Chr8, 30.91 cM
• Alliance: Nek1^em1Hdt page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details:

  CRISPR/Cas-mediated targeting introduced the mutation responsible for altering the lysine to a stop codon at position 764 (K764*). (J:390421)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nek1 Mutation: 84 strains or lines available

References

• Original: J:390648 Georgiadou, et al., Pml loss worsens NEK1-linked ALS and Pml induction drives NEK1 degradation, precluding disease onset. FEBS J. 2026
• All: 2 reference(s)