Tardbp^tm1.2Cjks
Targeted Allele Detail

Summary

• Symbol: Tardbp^tm1.2Cjks
• Name: TAR DNA binding protein; targeted mutation 1.2, C K James Shen
• MGI ID: MGI:5513108
• Synonyms: Tardbp^lx
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^tm1.2Cjks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were flanked by loxP sites and an FRT flanked neo cassette and a 29 bp deletion for genotyping were inserted in intron 3 via homologous recombination. The FRT flanked neo cassette was removed by germline expression of flp recombinase. (J:155958, J:190254)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 60 strains or lines available

References

• Original: J:155958 Wu LS, et al., TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis. Genesis. 2010 Jan;48(1):56-62
• All: 4 reference(s)