Mnx1^tm4(cre)Tmj
Targeted Allele Detail

Summary

• Symbol: Mnx1^tm4(cre)Tmj
• Name: motor neuron and pancreas homeobox 1; targeted mutation 4, Thomas M Jessell
• MGI ID: MGI:2447793
• Synonyms: Hb9-CRE, HB9^cre, HB9^Cre, Hlxb9^tm4(cre)Tmj
• Gene: Mnx1 Location: Chr5:29678821-29683468 bp, - strand Genetic Position: Chr5, 15.04 cM
• Alliance: Mnx1^tm4(cre)Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69623
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Mnx1^tm4(cre)Tmj expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mnx1 (MGI:109160)

• Mutation details: Exon 1 was disrupted by the insertion of a cassette containing an IRES-cre gene, a floxed neomycin gene, and a SV40 polyadenylation signal. (J:69623)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mnx1 (mouse) Summary of all recombinase alleles driven by Mnx1. Comparative matrix view of recombinase activities Alliance mouse Mnx1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mnx1 Mutation: 28 strains or lines available

References

• Original: J:69623 Yang X, et al., Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron. 2001 May;30(2):399-410
• All: 62 reference(s)