Stmn2^em1Jmi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stmn2^em1Jmi
• Name: stathmin-like 2; endonuclease-mediated mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:7494069
• Synonyms: Stmn2^-
• Gene: Stmn2 Location: Chr3:8574587-8626664 bp, + strand Genetic Position: Chr3, 2.15 cM
• Alliance: Stmn2^em1Jmi page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 1,233 bp deletion including exon 3, which encodes a large part of the tubulin-binding stathmin-like domain of the encoded protein and parts of the surrounding introns, as confirmed by DNA sequencing. Western blot analysis demonstrated absence of protein expression in brain lysates from adult homozygous mutant mice. (J:337175)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stmn2 Mutation: 41 strains or lines available

References

• Original: J:337175 Krus KL, et al., Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy. Cell Rep. 2022 Jun 28;39(13):111001
• All: 1 reference(s)