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Tg(SOD1*G85R/EYFP)737Alho
Transgene Detail
Summary
Symbol: Tg(SOD1*G85R/EYFP)737Alho
Name: transgene insertion 737, Arthur L Horwich
MGI ID: MGI:5630056
Synonyms: G85R SOD1-YFP
Transgene: Tg(SOD1*G85R/EYFP)737Alho  Location: unknown  
Alliance: Tg(SOD1*G85R/EYFP)737Alho page
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL/J)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(SOD1*G85R/EYFP)737Alho expresses 1 gene
 
Mutation detailsA 12 kb genomic fragment of human SOD carrying the glycine to arginine substitution at amino acid 85 (G85R) fused to EYFP coding sequence through its C-terminal coding sequence in exon 5 was used as the transgene. The G85R mutation results in a misfolded protein associated with amyotrophic lateral sclerosis in humans and the mutant fusion protein behaves as a misfolded monomer. Southern blot analysis indicates that line 737 carries multiple transgene insertions. (J:144475)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:144475 Wang J, et al., Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1392-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory