Fus^tm1.1Emcf
Targeted Allele Detail

Summary

• Symbol: Fus^tm1.1Emcf
• Name: fused in sarcoma; targeted mutation 1.1, Elizabeth MC Fisher
• MGI ID: MGI:6100933
• Synonyms: FUS Delta14, Fus^tm1Emcf
• Gene: Fus Location: Chr7:127565276-127581204 bp, + strand Genetic Position: Chr7, 69.87 cM
• Alliance: Fus^tm1.1Emcf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249965
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An A to G splice mutation was introduced betweeen exon 13 and 14 along with humanization of the coding sequence of exon 15 through the following sequence changes: g.14230 C to T, g.14232 A to T, g.14234 C to G, g.14260 A to G, and g.14266 ATTA insertion. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:249965)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Fus Mutation: 39 strains or lines available

References

• Original: J:249965 Devoy A, et al., Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in 'FUSDelta14' knockin mice. Brain. 2017 Nov 1;140(11):2797-2805
• All: 8 reference(s)