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Fus Gene Detail
Summary
  • Symbol
    Fus
  • Name
    fused in sarcoma
  • Synonyms
    D430004D17Rik, D930039C12Rik, hnRNP P2, pigpen, Tls, translocated in liposarcoma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353633
    NCBI Gene: 233908
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127565276-127581204 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    31
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353633
 protein coding gene Chr7:127565276-127584873 (+)
129S1/SvImJ ENSMUSG00200022118
 protein coding gene Chr7:114079915-114096554 (+)
129S1/SvImJ ENSMUSG00200022217
 protein coding gene Chr7:114095477-114098094 (+)
A/J ENSMUSG00195034568
 protein coding gene Chr7:118596578-118599210 (+)
A/J ENSMUSG00195034493
 protein coding gene Chr7:118580988-118597657 (+)
AKR/J ENSMUSG00220015877
 protein coding gene Chr7:112051194-112053817 (+)
AKR/J ENSMUSG00220015863
 protein coding gene Chr7:112035567-112052268 (+)
BALB/cJ ENSMUSG00180012053
 protein coding gene Chr7:115276404-115293105 (+)
BALB/cJ ENSMUSG00180012074
 protein coding gene Chr7:115292032-115294654 (+)
C3H/HeJ ENSMUSG00175013703
 protein coding gene Chr7:116018912-116021534 (+)
C3H/HeJ ENSMUSG00175013643
 protein coding gene Chr7:116003287-116019985 (+)
C57BL/6NJ ENSMUSG00215016766
 protein coding gene Chr7:115276380-115293077 (+)
C57BL/6NJ ENSMUSG00215016931
 protein coding gene Chr7:115292003-115294627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030533
 protein coding gene Chr7:130005701-130023157 (+)
CAST/EiJ ENSTCUG00005047081
 protein coding gene Chr7:118521067-118537673 (+)
CBA/J ENSMUSG00210022965
 protein coding gene Chr7:115757401-115774097 (+)
CBA/J ENSMUSG00210022985
 protein coding gene Chr7:115773024-115775646 (+)
DBA/2J ENSMUSG00185047055
 protein coding gene Chr7:120070232-120086928 (+)
DBA/2J ENSMUSG00185047102
 protein coding gene Chr7:120085855-120088477 (+)
FVB/NJ ENSMUSG00205037965
 protein coding gene Chr7:115713245-115729946 (+)
FVB/NJ ENSMUSG00205038211
 protein coding gene Chr7:115728872-115731496 (+)
JF1/MsJ ENSUMUG00000014122
 protein coding gene Chr7:125115211-125131848 (+)
LP/J ENSMUSG00230051426
 protein coding gene Chr7:126195386-126198003 (+)
LP/J ENSMUSG00230051419
 protein coding gene Chr7:126179825-126196463 (+)
NOD/ShiLtJ ENSMUSG00190017656
 protein coding gene Chr7:115922120-115924742 (+)
NOD/ShiLtJ ENSMUSG00190017620
 protein coding gene Chr7:115906496-115923193 (+)
NZO/HlLtJ ENSMUSG00225010173
 protein coding gene Chr7:124432168-124434790 (+)
NZO/HlLtJ ENSMUSG00225010140
 protein coding gene Chr7:124416543-124433241 (+)
PWK/PhJ ENSLUMG00010034527
 protein coding gene Chr7:114252081-114268749 (+)
SPRET/EiJ ENSMSPG00010011187
 protein coding gene Chr7:115514903-115530384 (+)
WSB/EiJ ENSIUOG00005030347
 protein coding gene Chr7:116607659-116624358 (+)



Homology
more
  • Human Ortholog
    FUS, FUS RNA binding protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUS, FUS RNA binding protein
  • Synonyms
    ALS6, altFUS, ETM4, FUS1, HNRNPP2, POMP75, TLS
  • Links
    NCBI Gene ID: 2521
    UniProt: P35637

  • Chr Location
    16p11.2; chr16:31180110-31196963 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fus mouse models; 5 with human FUS associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    255
  • cDNA Data
    172
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233908 NCBI Gene Model | MGI Sequence Detail 15929 C57BL/6J ±  kb
    transcript NM_139149 RefSeq | MGI Sequence Detail 1845 C57BL/6  
    polypeptide P56959 UniProt | EBI | MGI Sequence Detail 518 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 173
      Primer pair 3
      Other 1
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2443475, MGI:2445182
    References
    more
    • Summaries
      All 159
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 15
      Phenotypes 56
    • Earliest
      J:51309 Yang L, et al., Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem. 1998 Oct 23;273(43):27761-4
    • Latest
      J:375776 Genin EC, et al., SLP2/PHB Aggregates in ALS Mouse Models and Patients: Implications Beyond CHCHD10-Associated Motor Neuron Disease. Int J Mol Sci. 2025 Nov 8;26(22)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory