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Phenotypes Associated with This Genotype
Genotype
MGI:4843114
Allelic
Composition
Adarb1tm1.1Skwa/Adarb1tm1.1Skwa
Tg(SLC18A3-cre)KMisa/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1.1Skwa mutation (0 available); any Adarb1 mutation (22 available)
Tg(SLC18A3-cre)KMisa mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice survive 82 weeks compared with 105 weeks for wild-type mice

nervous system
• ramified axons innervate more than one neuromuscular junction unlike in wild-type mice
• ramified axons innervate more than one neuromuscular junction unlike in wild-type mice
• mice exhibit fewer large neurons in the facial and hypoglossal nerves compared to in wild-type mice
• however, the number of neurons in the oculomotor nerve is normal
• mice exhibit fewer large neurons compared to in wild-type mice
• mice exhibit fewer large neurons compared to in wild-type mice
• the number of myelinated axons in the ventral roots is decreased compared to in wild-type mice
• between 1 and 2 months of age and slowly decreasing beyond 1 year of age

behavior/neurological
N
• mice exhibit normal withdrawal response to noxious stimuli
• rotarod performance decreases from 5 weeks through 5 to 6 months of age and further after 18 months in comparison with wild-type mice
• of the hind limb and tail
• of the hind limb
• mice are hypokinetic unlike wild-type mice

muscle
• skeletal muscles exhibit pyknotic nuclear clumps unlike in wild-type mice

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis DOID:332 OMIM:PS105400
J:164294


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory