Phenotypes Associated with This Genotype

Genotype
MGI:8243876

• Allelic Composition: Anxa11^em1Lcu/Anxa11⁺
• Genetic Background: C57BL/6J-Anxa11^em1Lcu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle spasm ( J:371245 )

• paralysis is not seen up to 12 months of age, although occasional hindlimb spasms are seen

• spasms are less frequent than in homozygous mice from 8-9 months onward

behavior/neurological

behavior/neurological phenotype ( J:371245 )

N • mice exhibit intact working memory in the Y-maze and normal novelty discrimination

increased anxiety-related response ( J:371245 )

• mice at 10 months of age show anxiety-like behavior in the elevated plus maze, with fewer entries into the open arms

abnormal motor capabilities/coordination/movement ( J:371245 )

• mice show significant motor decline at 10 months of age

• onset and progression of disease is similar to that seen in homozygotes

decreased grip strength ( J:371245 )

decreased locomotor activity ( J:371245 )

• reduction in spontaneous locomotor activity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 23		DOID:0080225	OMIM:617839	J:371245