Tg(Thy1-DCTN1*G59S)M2Pcw
Transgene Detail

Summary

• Symbol: Tg(Thy1-DCTN1*G59S)M2Pcw
• Name: transgene insertion M2, Philip C Won
• MGI ID: MGI:5308396
• Synonyms: mutant p150 Glued
• Transgene: Tg(Thy1-DCTN1*G59S)M2Pcw Location: unknown
• Alliance: Tg(Thy1-DCTN1*G59S)M2Pcw page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-DCTN1*G59S)M2Pcw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DCTN1 (1639)

  Dctn1

  (MGI:107745)

• Mutation details: This transgene contains the mouse Thy1 (thymus cell antigen 1, theta, promoter (Thy1.2)) promoter driving expression of the full-length human dynactin 1 (DCTN1) cDNA sequence. A missense mutation associated with amyotrophic lateral sclerosis (ALS), G59S, was introduced into dynactin cDNA encoding the p150 subunit. A FLAG tag was also introduced at the C-terminal. Line M2 was generated. (J:132857)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:132857 Laird FM, et al., Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J Neurosci. 2008 Feb 27;28(9):1997-2005
• All: 4 reference(s)