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Targeted Allele Detail
Symbol: Psmc4tm1.1Ryot
Name: proteasome (prosome, macropain) 26S subunit, ATPase, 4; targeted mutation 1.1, Ryosuke Takahashi
MGI ID: MGI:5470093
Synonyms: Rpt3flox
Gene: Psmc4  Location: Chr7:27741127-27749517 bp, - strand  Genetic Position: Chr7, 16.11 cM
Alliance: Psmc4tm1.1Ryot page
Limb clasping and severe kyphosis in Psmc4tm1.1Ryot/Psmc4tm1.2Ryot Tg(SLC18A3-cre)KMisa/0 mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:193770
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the neo cassette and left exons 7 through 10 floxed. (J:193770)
Generation of the Psmc4tm1.1Ryot and Psmc4tm1.2Ryot alleles
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psmc4 Mutation:  17 strains or lines available
Original:  J:193770 Tashiro Y, et al., Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem. 2012 Dec 14;287(51):42984-94
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory