Fus^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Fus^tm1Ics
• Name: fused in sarcoma; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:6393525
• Synonyms: FUS^deltaNLS
• Gene: Fus Location: Chr7:127565276-127581204 bp, + strand Genetic Position: Chr7, 69.87 cM
• Alliance: Fus^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233532
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Altered localization)
• Mutation: Insertion
• Mutation details: The following elements were inserted into intron 12: the last 254 bp of intron 12, fused exon 13 (ENSMUSE00001235788) and 14 (ENSMUSE00001215589) coding sequences, a STOP cassette (containing 3x SV40 poly(A) signal sequences) and a second loxP site. This allele expresses a mutated protein lacking the NLS sequence that is encoded by exon 15 and only after Cre-mediated deletion of the inserted sequence will it express the wild-type protein. (J:233532)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fus Mutation: 57 strains or lines available

References

• Original: J:233532 Scekic-Zahirovic J, et al., Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO J. 2016 May 17;35(10):1077-97
• All: 10 reference(s)