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Transgene Detail
Symbol: Tg(SOD1*G93A)1Gur
Name: transgene insertion 1, Mark E Gurney
MGI ID: MGI:2183719
Synonyms: G1H, G93A, G93A+, G93AGurdl, G93A SOD1, G93A-SOD1, (G93A)Tg+, Gur1-G93A, hSOD1G93A, SOD1G93A, SOD1 G93A, SOD1 Tg, Tg(G93A-SOD1)1Gur, TgN(SOD1-G93A)1Gur, TgN[SOD1-G93A]1Gur, Tg(SOD1-G93A)1Gur
Transgene: Tg(SOD1*G93A)1Gur  Location: Chr12:97132574-97132574 bp  Genetic Position: Chr12, cytoband E
Alliance: Tg(SOD1*G93A)1Gur page
Presence of neurofilament spheroids in the spinal cord of an 82-day old Tg(SOD1)2Gur/0 mouse

Show the 5 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(SOD1*G93A)1Gur expresses 1 gene
Mutation detailsThis transgenic subline (designated G1H in J:76718) is derived from the G1 parental transgenic line (originally described in J:32665). This line carries a 40% expansion in transgene copy number compared to the original G1 line (described in J:32665, in MGI as Tg(SOD1*G93A)2Gur). The transgene construct is composed of the human SOD1 gene carrying a glycine to alanine transition at position 93 (G93A). The G93A mutation does not alter the activity of the protein. This line carries a high copy number maps to Mus Chr12:97,165,800 (coordinates from MGSC ver 37, mm9). (J:32665, J:76718)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 29 anatomical structure(s)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
This line, G1H, was derived from the original G1 line (now designated Tg(SOD1*G93A)2Gur) reported in J:32665.

Transgenic mice on a background that involves C57BL/6 and SJL express high levels of the transgene with a 4-fold increase in SOD activity, and exhibit a phenotype similar to amyotrophic lateral sclerosis (ALS) in humans. Hemizygous transgenic mice become paralyzed in one or more limbs and have a life span of approximately 19-23 weeks. Paralysis is due to loss of motor neurons from the spinal cord.

Original:  J:76718 Tu PH, et al., Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3155-60
All:  874 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.13
The Jackson Laboratory