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Isl1tm1(cre)Tmj
Targeted Allele Detail
Summary
Symbol: Isl1tm1(cre)Tmj
Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Thomas M Jessell
MGI ID: MGI:2447758
Synonyms: Isl1cre, Isl1-Cre, Isl1-IRES-Cre, Isl1tm1(cre)Cos, Isl-Cre, Islet1:Cre
Gene: Isl1  Location: Chr13:116434817-116446225 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Alliance: Isl1tm1(cre)Tmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80963
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Isl1tm1(cre)Tmj expression driven by 1 gene
 
Mutation detailsAn IRES-Cre-SV40pA cassette was inserted into the exon encoding the second LIM domain of Isl1. Endogenous regulatory sequences drive Cre expression in motor neurons and dorsal root and cranial sensory ganglia. (J:80963)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Isl1 (mouse)
Summary of all recombinase alleles driven by Isl1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:  33 strains or lines available
References
Original:  J:80963 Srinivas S, et al., Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol. 2001;1(1):4
All:  77 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory