Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Psen1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PSEN1
- Mouse genes Psen1
- Rat genes Psen1
- Zfish genes psen1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Psen1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	PSEN1	IMP		Human	PMID:17428795
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	PSEN1	IDA		Human	PMID:26280335
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Psen1	IGI	MGI:MGI:1891700	Mouse	PMID:16371134
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Psen1	IGI	MGI:MGI:3522097	Mouse	PMID:16371134
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Psen1	IMP		Mouse	PMID:16371134
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:21206757
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:12684521
Molecular Function	GO:0051117	ATPase binding	PSEN1	IPI	UniProtKB:O75110	Human	PMID:26094765
Molecular Function	GO:0008013	beta-catenin binding	PSEN1	IPI	UniProtKB:P35222	Human	PMID:9632714
Molecular Function	GO:0045296	cadherin binding	Psen1	IPI	PR:P09803	Mouse	PMID:11953314
Molecular Function	GO:0005262	calcium channel activity	PSEN1	IMP		Human	PMID:16959576
Molecular Function	GO:0004175	endopeptidase activity	PSEN1	IMP		Human	PMID:12297508
Molecular Function	GO:0004175	endopeptidase activity	PSEN1	IGI	UniProtKB:P05067	Human	PMID:12763021
Molecular Function	GO:0004175	endopeptidase activity	PSEN1	IDA		Human	PMID:8755489
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IMP	MGI:MGI:1932738	Mouse	PMID:11262239
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:17913918
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:15452145
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17920016
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IMP		Mouse	PMID:11953314
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:10206645
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IMP		Mouse	PMID:17556541
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IMP	MGI:MGI:3051523	Mouse	PMID:12391611
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IMP		Mouse	PMID:17097608
Molecular Function	GO:0004175	endopeptidase activity	Psen1	IDA		Rat	PMID:15456764\|RGD:1358417
Molecular Function	GO:0070851	growth factor receptor binding	PSEN1	IPI	UniProtKB:Q16620	Human	PMID:26094765
Molecular Function	GO:0030165	PDZ domain binding	PSEN1	IPI	UniProtKB:Q9NZJ7	Human	PMID:10551805
Molecular Function	GO:0008233	peptidase activity	Psen1	IDA		Rat	PMID:15456764\|RGD:1358417
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P27635	Human	PMID:10508860
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q9UMX0	Human	PMID:11076969
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P05067-4	Human	PMID:11083918
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P98084	Human	PMID:11083918
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q02410	Human	PMID:11083918
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q8WW43	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q92542	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q96BI3	Human	PMID:12297508
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q9NZ42	Human	PMID:12522139
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P56817	Human	PMID:12901838
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q9NZ42	Human	PMID:15322109
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q02410	Human	PMID:16007100
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P49755	Human	PMID:16641999
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q92542	Human	PMID:16641999
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q92542	Human	PMID:18201567
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P05067-4	Human	PMID:21115843
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q9UMX0	Human	PMID:21143716
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P05067	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P50502	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q16543	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q9BQ95	Human	PMID:21163940
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P49755	Human	PMID:25959826
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q96QE2	Human	PMID:26094765
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q92542	Human	PMID:29611543
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q9NZC2	Human	PMID:29611543
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P55061	Human	PMID:30559186
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q92542	Human	PMID:30559186
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:Q9NZ42	Human	PMID:30559186
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P05067	Human	PMID:9223340
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P05067-4	Human	PMID:9223340
Molecular Function	GO:0005515	protein binding	PSEN1	IPI	UniProtKB:P10636	Human	PMID:9689133
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:P14211	Mouse	MGI:MGI:5553221\|PMID:23585889
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:P52795	Mouse	MGI:MGI:3619856\|PMID:16511561
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:Q8BVF7	Mouse	MGI:MGI:6478051\|PMID:12522139
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:Q3UHK1	Mouse	MGI:MGI:6093233\|PMID:26094765
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:P35438	Mouse	MGI:MGI:6694380\|PMID:32033586
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:Q9Z280	Mouse	MGI:MGI:6092896\|PMID:16449386
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:Q9WV31	Mouse	MGI:MGI:5299950\|PMID:22036569
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:P46096	Mouse	MGI:MGI:5780348\|PMID:27036734
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:Q9Z1G4	Mouse	MGI:MGI:4839422\|PMID:20541250
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:P35438	Mouse	MGI:MGI:6788519\|PMID:34646371
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:Q8CIQ7	Mouse	PMID:10854253
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:Q8BVF7	Mouse	PMID:21597003
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:Q8BVF7	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:Q9CQR7	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:P57716	Mouse	PMID:15474363
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:P26450	Mouse	PMID:15192701
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:Q60625	Mouse	PMID:11719200
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:Q9WV60	Mouse	PMID:12805290
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:P57716	Mouse	PMID:21597003
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:P09803	Mouse	PMID:15192701
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:Q9CQR7	Mouse	PMID:21597003
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:P15116	Mouse	PMID:15192701
Molecular Function	GO:0005515	protein binding	Psen1	IPI	PR:Q61483	Mouse	PMID:12794186
Molecular Function	GO:0005515	protein binding	Psen1	IPI	UniProtKB:Q5PQQ3	Rat	PMID:12297508\|RGD:1358419
Molecular Function	GO:0005515	protein binding	Psen1	IPI	RGD:631418	Rat	PMID:15456764\|RGD:1358417
Molecular Function	GO:0005515	protein binding	Psen1	IPI	RGD:1310013	Rat	PMID:22535952\|RGD:6484662
Cellular Component	GO:0016235	aggresome	PSEN1	IDA		Human	PMID:21143716
Cellular Component	GO:0030424	axon	Psen1	IDA		Mouse	PMID:11740561
Cellular Component	GO:0005938	cell cortex	Psen1	IDA		Mouse	MGI:MGI:2150214\|PMID:11517342
Cellular Component	GO:0030054	cell junction	PSEN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009986	cell surface	Psen1	IDA		Rat	PMID:11570818\|RGD:1304229
Cellular Component	GO:0005813	centrosome	PSEN1	IDA		Human	PMID:9298903
Cellular Component	GO:0035253	ciliary rootlet	Psen1	IDA		Mouse	PMID:16018997
Cellular Component	GO:0005737	cytoplasm	Psen1	IDA		Mouse	MGI:MGI:2150214\|PMID:11517342
Cellular Component	GO:0005737	cytoplasm	Psen1	IDA		Rat	PMID:16298244\|RGD:13801190
Cellular Component	GO:0031410	cytoplasmic vesicle	Psen1	IDA		Mouse	PMID:11740561
Cellular Component	GO:0030425	dendrite	Psen1	IDA		Mouse	PMID:8922407
Cellular Component	GO:0043198	dendritic shaft	Psen1	IDA		Mouse	PMID:12805290
Cellular Component	GO:0005769	early endosome	Psen1	IDA		Rat	PMID:20126630\|RGD:13702254
Cellular Component	GO:0005783	endoplasmic reticulum	PSEN1	IDA		Human	PMID:15274632
Cellular Component	GO:0005783	endoplasmic reticulum	PSEN1	IDA		Human	PMID:9246482
Cellular Component	GO:0005783	endoplasmic reticulum	Psen1	IDA		Mouse	PMID:19376115
Cellular Component	GO:0005783	endoplasmic reticulum	Psen1	IDA		Mouse	PMID:10854253
Cellular Component	GO:0070765	gamma-secretase complex	PSEN1	IDA		Human	PMID:10801983
Cellular Component	GO:0070765	gamma-secretase complex	PSEN1	IDA		Human	PMID:12297508
Cellular Component	GO:0070765	gamma-secretase complex	PSEN1	IGI	UniProtKB:P05067	Human	PMID:12763021
Cellular Component	GO:0070765	gamma-secretase complex	PSEN1	IDA		Human	PMID:26280335
Cellular Component	GO:0070765	gamma-secretase complex	Psen1	IDA		Mouse	PMID:12684521
Cellular Component	GO:0070765	gamma-secretase complex	Psen1	IDA		Mouse	PMID:16371134
Cellular Component	GO:0070765	gamma-secretase complex	Psen1	IDA		Mouse	PMID:16641999
Cellular Component	GO:0070765	gamma-secretase complex	Psen1	IDA		Mouse	PMID:20674680
Cellular Component	GO:0098978	glutamatergic synapse	Psen1	IDA		Mouse	PMID:23083742
Cellular Component	GO:0098978	glutamatergic synapse	Psen1	IMP		Mouse	PMID:23083742
Cellular Component	GO:0098978	glutamatergic synapse	Psen1	IEP		Mouse	PMID:23083742
Cellular Component	GO:0005794	Golgi apparatus	PSEN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	PSEN1	IDA		Human	PMID:15274632
Cellular Component	GO:0005794	Golgi apparatus	PSEN1	IDA		Human	PMID:9246482
Cellular Component	GO:0005794	Golgi apparatus	PSEN1	IDA		Human	PMID:9632714
Cellular Component	GO:0005794	Golgi apparatus	Psen1	IDA		Mouse	PMID:19376115
Cellular Component	GO:0005794	Golgi apparatus	Psen1	IDA		Mouse	PMID:16018997
Cellular Component	GO:0030426	growth cone	PSEN1	IDA		Human	PMID:15004326
Cellular Component	GO:0030426	growth cone	Psen1	IDA		Mouse	PMID:12805290
Cellular Component	GO:0005622	intracellular anatomical structure	Psen1	IDA		Mouse	PMID:10421573
Cellular Component	GO:0000776	kinetochore	PSEN1	IDA		Human	PMID:9298903
Cellular Component	GO:0005765	lysosomal membrane	Psen1	IDA		Rat	PMID:12736250\|RGD:724403
Cellular Component	GO:0016020	membrane	PSEN1	IDA		Human	PMID:22375059
Cellular Component	GO:0016020	membrane	PSEN1	IDA		Human	PMID:26280335
Cellular Component	GO:0016020	membrane	Psen1	IDA		Mouse	PMID:15634781
Cellular Component	GO:0016020	membrane	Psen1	IDA		Mouse	PMID:15886206
Cellular Component	GO:0016020	membrane	Psen1	IDA		Mouse	PMID:10854253
Cellular Component	GO:0016020	membrane	Psen1	IDA		Mouse	PMID:15474363
Cellular Component	GO:0016020	membrane	Psen1	IDA		Mouse	PMID:12684521
Cellular Component	GO:0016020	membrane	psen1	IDA		Zfish	PMID:10521267
Cellular Component	GO:0045121	membrane raft	PSEN1	IDA		Human	PMID:20299451
Cellular Component	GO:0045121	membrane raft	Psen1	IDA		Rat	PMID:17433308\|RGD:1626321
Cellular Component	GO:0043227	membrane-bounded organelle	Psen1	IDA		Mouse	PMID:12805290
Cellular Component	GO:0005743	mitochondrial inner membrane	Psen1	IDA		Rat	PMID:12099705\|RGD:729648
Cellular Component	GO:0005739	mitochondrion	PSEN1	IDA		Human	PMID:12377771
Cellular Component	GO:0005739	mitochondrion	Psen1	IDA		Rat	PMID:15456764\|RGD:1358417
Cellular Component	GO:0031594	neuromuscular junction	Psen1	IDA		Rat	PMID:16595164\|RGD:1601507
Cellular Component	GO:0043005	neuron projection	PSEN1	IDA		Human	PMID:15004326
Cellular Component	GO:0043005	neuron projection	Psen1	IDA		Rat	PMID:17433308\|RGD:1626321
Cellular Component	GO:0043025	neuronal cell body	Psen1	IDA		Mouse	PMID:8922407
Cellular Component	GO:0043025	neuronal cell body	Psen1	IDA		Mouse	PMID:12805290
Cellular Component	GO:0031965	nuclear membrane	PSEN1	IDA		Human	PMID:9298903
Cellular Component	GO:0005640	nuclear outer membrane	PSEN1	IDA		Human	PMID:9246482
Cellular Component	GO:0005654	nucleoplasm	PSEN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PSEN1	IMP		Human	PMID:10508860
Cellular Component	GO:0005634	nucleus	Psen1	IDA		Mouse	PMID:12794186
Cellular Component	GO:0005886	plasma membrane	PSEN1	IDA		Human	PMID:15274632
Cellular Component	GO:0005886	plasma membrane	PSEN1	IDA		Human	PMID:21143716
Cellular Component	GO:0005886	plasma membrane	Psen1	IDA		Mouse	MGI:MGI:2150214\|PMID:11517342
Cellular Component	GO:0005886	plasma membrane	Psen1	IDA		Mouse	PMID:17097608
Cellular Component	GO:0005886	plasma membrane	Psen1	IDA		Rat	PMID:20126630\|RGD:13702254
Cellular Component	GO:0042734	presynaptic membrane	Psen1	IDA		Rat	PMID:20126630\|RGD:13702254
Cellular Component	GO:0032991	protein-containing complex	PSEN1	IMP		Human	PMID:10508860
Cellular Component	GO:0032991	protein-containing complex	Psen1	IDA		Rat	PMID:15456764\|RGD:1358417
Cellular Component	GO:0005791	rough endoplasmic reticulum	PSEN1	IDA		Human	PMID:9632714
Cellular Component	GO:0042383	sarcolemma	Psen1	IDA		Rat	PMID:16595164\|RGD:1601507
Cellular Component	GO:0005790	smooth endoplasmic reticulum	PSEN1	IDA		Human	PMID:10508860
Cellular Component	GO:0005790	smooth endoplasmic reticulum	PSEN1	IDA		Human	PMID:9632714
Cellular Component	GO:0045202	synapse	Psen1	IDA		Rat	PMID:16298244\|RGD:13801190
Cellular Component	GO:0097060	synaptic membrane	Psen1	IDA		Rat	PMID:20126630\|RGD:13702254
Cellular Component	GO:0008021	synaptic vesicle	Psen1	IDA		Rat	PMID:20126630\|RGD:13702254
Biological Process	GO:0042987	amyloid precursor protein catabolic process	PSEN1	IMP		Human	PMID:12297508
Biological Process	GO:0042987	amyloid precursor protein catabolic process	PSEN1	IGI	UniProtKB:P05067	Human	PMID:12763021
Biological Process	GO:0042987	amyloid precursor protein catabolic process	PSEN1	IDA		Human	PMID:27608597
Biological Process	GO:0042987	amyloid precursor protein catabolic process	Psen1	IMP	MGI:MGI:2179062	Mouse	PMID:11567612
Biological Process	GO:0042987	amyloid precursor protein catabolic process	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:10206645
Biological Process	GO:0042987	amyloid precursor protein catabolic process	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:15452145
Biological Process	GO:0042987	amyloid precursor protein catabolic process	Psen1	IMP	MGI:MGI:2449304	Mouse	PMID:11567612
Biological Process	GO:0042982	amyloid precursor protein metabolic process	PSEN1	IDA		Human	PMID:26280335
Biological Process	GO:0034205	amyloid-beta formation	PSEN1	IMP		Human	PMID:12297508
Biological Process	GO:0034205	amyloid-beta formation	PSEN1	IGI	UniProtKB:P05067	Human	PMID:12763021
Biological Process	GO:0034205	amyloid-beta formation	PSEN1	IMP		Human	PMID:26280335
Biological Process	GO:0034205	amyloid-beta formation	PSEN1	IDA		Human	PMID:27608597
Biological Process	GO:0034205	amyloid-beta formation	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:20130175
Biological Process	GO:0034205	amyloid-beta formation	Psen1	IMP		Mouse	PMID:16371134
Biological Process	GO:0034205	amyloid-beta formation	Psen1	IGI	MGI:MGI:3522097	Mouse	PMID:16371134
Biological Process	GO:0034205	amyloid-beta formation	Psen1	IGI	MGI:MGI:1891700	Mouse	PMID:16371134
Biological Process	GO:0034205	amyloid-beta formation	psen1	IMP	ZFIN:ZDB-MRPHLNO-080421-1	Zfish	PMID:23666177
Biological Process	GO:0034205	amyloid-beta formation	psen1	IDA		Zfish	PMID:10521267
Biological Process	GO:0050435	amyloid-beta metabolic process	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:12684521
Biological Process	GO:0042640	anagen	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15525534
Biological Process	GO:0097190	apoptotic signaling pathway	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15148382
Biological Process	GO:0048143	astrocyte activation	PSEN1	IGI	UniProtKB:P05067	Human	PMID:20445063
Biological Process	GO:0002265	astrocyte activation involved in immune response	PSEN1	IGI	UniProtKB:A0A0R4J0I9,UniProtKB:P05067	Human	PMID:23152628
Biological Process	GO:0000045	autophagosome assembly	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:15452145
Biological Process	GO:0006914	autophagy	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:15123735
Biological Process	GO:0001568	blood vessel development	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:9153393
Biological Process	GO:0001568	blood vessel development	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:16079160
Biological Process	GO:0001568	blood vessel development	Psen1	IMP	MGI:MGI:3051523	Mouse	PMID:15254914
Biological Process	GO:0007420	brain development	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:9153393
Biological Process	GO:0007420	brain development	psen1	IMP	ZFIN:ZDB-GENO-130220-5	Zfish	PMID:23345232
Biological Process	GO:0007420	brain development	psen1	IMP	ZFIN:ZDB-MRPHLNO-080421-1	Zfish	PMID:19563801
Biological Process	GO:0048854	brain morphogenesis	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17614943
Biological Process	GO:0021870	Cajal-Retzius cell differentiation	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:15548218
Biological Process	GO:0060070	canonical Wnt signaling pathway	psen1	IMP	ZFIN:ZDB-GENO-130220-5	Zfish	PMID:23345232
Biological Process	GO:0001708	cell fate specification	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15525534
Biological Process	GO:0098609	cell-cell adhesion	PSEN1	IMP		Human	PMID:11953314
Biological Process	GO:1904646	cellular response to amyloid-beta	PSEN1	IGI	UniProtKB:A0A0R4J0I9,UniProtKB:P05067	Human	PMID:23152628
Biological Process	GO:0021549	cerebellum development	Psen1	IEP		Rat	PMID:16298244\|RGD:13801190
Biological Process	GO:0021795	cerebral cortex cell migration	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:16079160
Biological Process	GO:0021987	cerebral cortex development	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:16079160
Biological Process	GO:0015871	choline transport	Psen1	IMP	MGI:MGI:1930937	Mouse	PMID:17196556
Biological Process	GO:0006974	DNA damage response	PSEN1	IDA		Human	PMID:25542424
Biological Process	GO:0006974	DNA damage response	Psen1	IMP	MGI:MGI:1930937	Mouse	PMID:12460542
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:10557208
Biological Process	GO:0009790	embryo development	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:10518543
Biological Process	GO:0009790	embryo development	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:16079160
Biological Process	GO:0009790	embryo development	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:10557208
Biological Process	GO:0009790	embryo development	Psen1	IMP	MGI:MGI:3051523	Mouse	PMID:12391611
Biological Process	GO:0030326	embryonic limb morphogenesis	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:16169548
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PSEN1	IDA		Human	PMID:17431506
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PSEN1	IGI	UniProtKB:P49769	Human	PMID:16959576
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PSEN1	IMP		Human	PMID:25394380
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Psen1	IMP	MGI:MGI:1930937	Mouse	PMID:12460542
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:15009636
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:15123735
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17431506
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Psen1	IMP	MGI:MGI:1930937	Mouse	PMID:10662826
Biological Process	GO:0050673	epithelial cell proliferation	Psen1	IGI	MGI:MGI:1891700	Mouse	PMID:17913918
Biological Process	GO:0030900	forebrain development	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15148382
Biological Process	GO:0010467	gene expression	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:15009636
Biological Process	GO:0007507	heart development	Psen1	IMP	MGI:MGI:3051523	Mouse	PMID:15254914
Biological Process	GO:0001947	heart looping	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:10557208
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15122901
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Psen1	IMP	MGI:MGI:2684616,MGI:MGI:2684620	Mouse	PMID:12431992
Biological Process	GO:0098712	L-glutamate import across plasma membrane	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:15009636
Biological Process	GO:0007611	learning or memory	PSEN1	IGI	UniProtKB:P04156,UniProtKB:P05067	Human	PMID:20445063
Biological Process	GO:0007611	learning or memory	PSEN1	IGI	UniProtKB:P05067,UniProtKB:P41594	Human	PMID:24012003
Biological Process	GO:0007611	learning or memory	PSEN1	IGI	UniProtKB:P05067,UniProtKB:P97484	Human	PMID:24052308
Biological Process	GO:0007611	learning or memory	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15066262
Biological Process	GO:0040011	locomotion	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15148382
Biological Process	GO:0001946	lymphangiogenesis	psen1	IMP	ZFIN:ZDB-MRPHLNO-101216-8	Zfish	PMID:20466977
Biological Process	GO:0030318	melanocyte differentiation	psen1	IMP	ZFIN:ZDB-MRPHLNO-080421-1	Zfish	PMID:19563801
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	PSEN1	IDA		Human	PMID:15274632
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	Psen1	IMP		Rat	PMID:17433308\|RGD:1626321
Biological Process	GO:0007613	memory	PSEN1	IGI	UniProtKB:P05067	Human	PMID:11880515
Biological Process	GO:0007613	memory	Psen1	IMP	MGI:MGI:2179062	Mouse	PMID:11567612
Biological Process	GO:0007613	memory	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15148382
Biological Process	GO:0007613	memory	Psen1	IMP	MGI:MGI:2449304	Mouse	PMID:11567612
Biological Process	GO:0007613	memory	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17614943
Biological Process	GO:0007613	memory	Psen1	IMP	MGI:MGI:2155978	Mouse	PMID:11738035
Biological Process	GO:0006839	mitochondrial transport	Psen1	IMP		Mouse	PMID:12805290
Biological Process	GO:0043011	myeloid dendritic cell differentiation	Psen1	IMP	MGI:MGI:2449306	Mouse	PMID:23913046
Biological Process	GO:0002573	myeloid leukocyte differentiation	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15122901
Biological Process	GO:0043066	negative regulation of apoptotic process	PSEN1	IMP		Human	PMID:10508860
Biological Process	GO:0043066	negative regulation of apoptotic process	PSEN1	IDA		Human	PMID:10805794
Biological Process	GO:0043066	negative regulation of apoptotic process	Psen1	IDA		Mouse	PMID:15192701
Biological Process	GO:0043066	negative regulation of apoptotic process	Psen1	IDA		Rat	PMID:11895366\|RGD:1304239
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15148382
Biological Process	GO:0050771	negative regulation of axonogenesis	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:15548218
Biological Process	GO:1904797	negative regulation of core promoter binding	PSEN1	IMP		Human	PMID:10508860
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	Psen1	IMP		Mouse	MGI:MGI:4887523\|PMID:20208556
Biological Process	GO:0010629	negative regulation of gene expression	PSEN1	IGI	UniProtKB:P05067	Human	PMID:28008308
Biological Process	GO:0010629	negative regulation of gene expression	PSEN1	IGI	UniProtKB:P05067	Human	PMID:29061364
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Psen1	IMP		Rat	PMID:11895366\|RGD:1304239
Biological Process	GO:0006469	negative regulation of protein kinase activity	Psen1	IMP		Mouse	PMID:12805290
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15148382
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PSEN1	IMP		Human	PMID:10508860
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Psen1	IMP		Mouse	MGI:MGI:4887523\|PMID:20208556
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Psen1	IMP		Mouse	MGI:MGI:4887523\|PMID:20208556
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	Psen1	IMP		Mouse	MGI:MGI:4887523\|PMID:20208556
Biological Process	GO:0003407	neural retina development	Psen1	IEP		Rat	PMID:12401445\|RGD:729595
Biological Process	GO:0022008	neurogenesis	Psen1	IMP	MGI:MGI:2155978	Mouse	PMID:11738035
Biological Process	GO:0022008	neurogenesis	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:9160754
Biological Process	GO:0051402	neuron apoptotic process	Psen1	IGI	MGI:MGI:88059	Mouse	PMID:16478525
Biological Process	GO:0070050	neuron cellular homeostasis	Psen1	IGI	MGI:MGI:88059	Mouse	PMID:12431992
Biological Process	GO:0070050	neuron cellular homeostasis	Psen1	IMP	MGI:MGI:2684616,MGI:MGI:2684620	Mouse	PMID:12431992
Biological Process	GO:0048666	neuron development	Psen1	IMP		Mouse	MGI:MGI:6377719\|PMID:21325529
Biological Process	GO:0048666	neuron development	Psen1	IMP	MGI:MGI:3051523	Mouse	PMID:12391611
Biological Process	GO:0030182	neuron differentiation	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:10821758
Biological Process	GO:0001764	neuron migration	Psen1	IMP	MGI:MGI:3051523	Mouse	PMID:12391611
Biological Process	GO:0001764	neuron migration	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:10821758
Biological Process	GO:0001764	neuron migration	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:15163631
Biological Process	GO:0001764	neuron migration	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:10421573
Biological Process	GO:1990535	neuron projection maintenance	PSEN1	IGI	UniProtKB:P04156,UniProtKB:P05067	Human	PMID:20445063
Biological Process	GO:0007220	Notch receptor processing	PSEN1	IDA		Human	PMID:27608597
Biological Process	GO:0007220	Notch receptor processing	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:20130175
Biological Process	GO:0007220	Notch receptor processing	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:10206645
Biological Process	GO:0007220	Notch receptor processing	Psen1	IMP	MGI:MGI:3051523	Mouse	PMID:12391611
Biological Process	GO:0007219	Notch signaling pathway	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:10821758
Biological Process	GO:0007219	Notch signaling pathway	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:16715081
Biological Process	GO:0007219	Notch signaling pathway	Psen1	IMP	MGI:MGI:1932738	Mouse	PMID:11262239
Biological Process	GO:0007219	Notch signaling pathway	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17698590
Biological Process	GO:0007219	Notch signaling pathway	psen1	IMP	ZFIN:ZDB-GENO-130220-5	Zfish	PMID:23345232
Biological Process	GO:0007219	Notch signaling pathway	psen1	IDA		Zfish	PMID:25814654
Biological Process	GO:0071632	optomotor response	psen1	IMP	ZFIN:ZDB-MRPHLNO-080422-3	Zfish	PMID:28623607
Biological Process	GO:1905908	positive regulation of amyloid fibril formation	PSEN1	IGI	UniProtKB:P05067	Human	PMID:11880515
Biological Process	GO:0043065	positive regulation of apoptotic process	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:16169548
Biological Process	GO:0043085	positive regulation of catalytic activity	PSEN1	IDA		Human	PMID:15274632
Biological Process	GO:0050820	positive regulation of coagulation	Psen1	IMP	MGI:MGI:2446469	Mouse	PMID:12646573
Biological Process	GO:0060999	positive regulation of dendritic spine development	PSEN1	IMP		Human	PMID:21951279
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	PSEN1	IMP		Human	PMID:23794287
Biological Process	GO:0010628	positive regulation of gene expression	PSEN1	IGI	UniProtKB:P05067	Human	PMID:28008308
Biological Process	GO:0010628	positive regulation of gene expression	PSEN1	IGI	UniProtKB:P05067	Human	PMID:29061364
Biological Process	GO:0045821	positive regulation of glycolytic process	PSEN1	IGI	UniProtKB:P05067	Human	PMID:29061364
Biological Process	GO:0002038	positive regulation of L-glutamate import across plasma membrane	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:15009636
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Psen1	IMP		Mouse	PMID:15896720
Biological Process	GO:0042327	positive regulation of phosphorylation	PSEN1	IGI	UniProtKB:P05067	Human	PMID:25707991
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Psen1	IMP		Mouse	MGI:MGI:4887523\|PMID:20208556
Biological Process	GO:0032092	positive regulation of protein binding	PSEN1	IGI	UniProtKB:P49768,UniProtKB:P97484	Human	PMID:24052308
Biological Process	GO:0042307	positive regulation of protein import into nucleus	PSEN1	IMP		Human	PMID:10508860
Biological Process	GO:0045860	positive regulation of protein kinase activity	Psen1	IDA		Mouse	PMID:15192701
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Psen1	IMP		Mouse	PMID:15896720
Biological Process	GO:0001921	positive regulation of receptor recycling	Psen1	IMP		Mouse	MGI:MGI:4887523\|PMID:20208556
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	PSEN1	IGI	UniProtKB:P05067	Human	PMID:29061364
Biological Process	GO:0009791	post-embryonic development	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:10518543
Biological Process	GO:0140249	protein catabolic process at postsynapse	Psen1	IEP		Mouse	PMID:23083742
Biological Process	GO:0140249	protein catabolic process at postsynapse	Psen1	IDA		Mouse	PMID:23083742
Biological Process	GO:0140249	protein catabolic process at postsynapse	Psen1	IMP		Mouse	PMID:23083742
Biological Process	GO:0006486	protein glycosylation	Psen1	IMP	MGI:MGI:2446469	Mouse	PMID:12646573
Biological Process	GO:0051604	protein maturation	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15280425
Biological Process	GO:0051604	protein maturation	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:11943765
Biological Process	GO:0019538	protein metabolic process	Psen1	IMP		Mouse	PMID:11953314
Biological Process	GO:0019538	protein metabolic process	Psen1	IDA		Mouse	PMID:17097608
Biological Process	GO:0019538	protein metabolic process	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17097608
Biological Process	GO:0016485	protein processing	PSEN1	IMP		Human	PMID:12297508
Biological Process	GO:0016485	protein processing	PSEN1	IGI	UniProtKB:P05067	Human	PMID:12763021
Biological Process	GO:0016485	protein processing	PSEN1	IDA		Human	PMID:15274632
Biological Process	GO:0016485	protein processing	PSEN1	IDA		Human	PMID:27608597
Biological Process	GO:0016485	protein processing	Psen1	IMP	MGI:MGI:2449304	Mouse	PMID:11567612
Biological Process	GO:0016485	protein processing	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:10206645
Biological Process	GO:0016485	protein processing	Psen1	IMP	MGI:MGI:2179062	Mouse	PMID:11567612
Biological Process	GO:0016485	protein processing	Psen1	IDA		Rat	PMID:15456764\|RGD:1358417
Biological Process	GO:0015031	protein transport	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:11943765
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	Psen1	IMP		Mouse	MGI:MGI:2150214\|PMID:11517342
Biological Process	GO:0052548	regulation of endopeptidase activity	psen1	IDA		Zfish	PMID:25814654
Biological Process	GO:0007176	regulation of epidermal growth factor-activated receptor activity	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17556541
Biological Process	GO:0010468	regulation of gene expression	PSEN1	IGI	UniProtKB:P05067	Human	PMID:26200696
Biological Process	GO:0010975	regulation of neuron projection development	PSEN1	IMP		Human	PMID:15004326
Biological Process	GO:0042325	regulation of phosphorylation	PSEN1	IDA		Human	PMID:9689133
Biological Process	GO:0099175	regulation of postsynapse organization	Psen1	IEP		Mouse	PMID:23083742
Biological Process	GO:0099175	regulation of postsynapse organization	Psen1	IDA		Mouse	PMID:23083742
Biological Process	GO:0099175	regulation of postsynapse organization	Psen1	IMP		Mouse	PMID:23083742
Biological Process	GO:0043393	regulation of protein binding	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17920016
Biological Process	GO:0060075	regulation of resting membrane potential	Psen1	IMP	MGI:MGI:2149116	Mouse	PMID:15548218
Biological Process	GO:0048167	regulation of synaptic plasticity	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:11814648
Biological Process	GO:0048167	regulation of synaptic plasticity	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:15066262
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Psen1	IMP	MGI:MGI:1930937	Mouse	PMID:10097174
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Psen1	IMP		Mouse	PMID:17088253
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Psen1	IDA		Mouse	PMID:17088253
Biological Process	GO:0001666	response to hypoxia	psen1	IMP	ZFIN:ZDB-MRPHLNO-150820-3	Zfish	PMID:27031468
Biological Process	GO:0001666	response to hypoxia	psen1	IDA		Zfish	PMID:25814654
Biological Process	GO:0006979	response to oxidative stress	Psen1	IGI	MGI:MGI:88059	Mouse	PMID:16478525
Biological Process	GO:0006979	response to oxidative stress	Psen1	IMP	MGI:MGI:1930937	Mouse	PMID:10097174
Biological Process	GO:0035282	segmentation	Psen1	IMP	MGI:MGI:1932738	Mouse	PMID:11262239
Biological Process	GO:0035282	segmentation	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:16079160
Biological Process	GO:0051208	sequestering of calcium ion	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:15009636
Biological Process	GO:0048705	skeletal system morphogenesis	Psen1	IMP	MGI:MGI:1857974	Mouse	PMID:9160754
Biological Process	GO:0043589	skin morphogenesis	Psen1	IMP		Mouse	MGI:MGI:4887523\|PMID:20208556
Biological Process	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	Psen1	IGI	MGI:MGI:88059	Mouse	PMID:12431992
Biological Process	GO:0061053	somite development	psen1	IMP	ZFIN:ZDB-MRPHLNO-080421-1	Zfish	PMID:12941610
Biological Process	GO:0061053	somite development	psen1	IMP	ZFIN:ZDB-MRPHLNO-080421-1	Zfish	PMID:19563801
Biological Process	GO:0001756	somitogenesis	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:19779553
Biological Process	GO:0001756	somitogenesis	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:9153393
Biological Process	GO:0001756	somitogenesis	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:10557208
Biological Process	GO:0036269	swimming behavior	psen1	IMP	ZFIN:ZDB-GENO-130220-5	Zfish	PMID:23345232
Biological Process	GO:0050808	synapse organization	PSEN1	IGI	UniProtKB:P05067,UniProtKB:P41594	Human	PMID:24012003
Biological Process	GO:0016080	synaptic vesicle targeting	Psen1	IMP		Mouse	PMID:12805290
Biological Process	GO:0002286	T cell activation involved in immune response	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17698590
Biological Process	GO:0050852	T cell receptor signaling pathway	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17698590
Biological Process	GO:0048538	thymus development	Psen1	IGI	MGI:MGI:109284	Mouse	PMID:17698590
Biological Process	GO:0048538	thymus development	Psen1	IMP	MGI:MGI:1930934	Mouse	PMID:17698590

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.