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Gene Ontology Browser
Term Detail
GO term:smooth endoplasmic reticulum
Synonym: SER
Synonym: smooth ER
GO id:GO:0005790
Definition:The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
Number of paths to term: 16

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aendomembrane system
                                        part-ofendoplasmic reticulum
                                                part-ofendoplasmic reticulum part +
                                                is-amembrane stack
                                                is-aplasmodesmatal endoplasmic reticulum
                                                is-arough endoplasmic reticulum +
                                                is-asarcoplasmic reticulum +
                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                        part-ofsmooth endoplasmic reticulum lumen
                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                        part-ofsmooth endoplasmic reticulum part +
                                                        part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasm
                                                        part-ofcytoplasmic part
                                                                is-aendoplasmic reticulum
                                                                        part-ofendoplasmic reticulum part +
                                                                        is-amembrane stack
                                                                        is-aplasmodesmatal endoplasmic reticulum
                                                                        is-arough endoplasmic reticulum +
                                                                        is-asarcoplasmic reticulum +
                                                                        is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                                part-ofsmooth endoplasmic reticulum lumen
                                                                                part-ofsmooth endoplasmic reticulum membrane +
                                                                                part-ofsmooth endoplasmic reticulum part +
                                                                                part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasmic part
                                                        is-aendoplasmic reticulum
                                                                part-ofendoplasmic reticulum part +
                                                                is-amembrane stack
                                                                is-aplasmodesmatal endoplasmic reticulum
                                                                is-arough endoplasmic reticulum +
                                                                is-asarcoplasmic reticulum +
                                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                        part-ofsmooth endoplasmic reticulum lumen
                                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                                        part-ofsmooth endoplasmic reticulum part +
                                                                        part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aintracellular organelle
                                                        is-aintracellular membrane-bounded organelle
                                                                is-aendoplasmic reticulum
                                                                        part-ofendoplasmic reticulum part +
                                                                        is-amembrane stack
                                                                        is-aplasmodesmatal endoplasmic reticulum
                                                                        is-arough endoplasmic reticulum +
                                                                        is-asarcoplasmic reticulum +
                                                                        is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                                part-ofsmooth endoplasmic reticulum lumen
                                                                                part-ofsmooth endoplasmic reticulum membrane +
                                                                                part-ofsmooth endoplasmic reticulum part +
                                                                                part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-aendoplasmic reticulum
                                                                part-ofendoplasmic reticulum part +
                                                                is-amembrane stack
                                                                is-aplasmodesmatal endoplasmic reticulum
                                                                is-arough endoplasmic reticulum +
                                                                is-asarcoplasmic reticulum +
                                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                        part-ofsmooth endoplasmic reticulum lumen
                                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                                        part-ofsmooth endoplasmic reticulum part +
                                                                        part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasmic part
                                                is-aendoplasmic reticulum
                                                        part-ofendoplasmic reticulum part +
                                                        is-amembrane stack
                                                        is-aplasmodesmatal endoplasmic reticulum
                                                        is-arough endoplasmic reticulum +
                                                        is-asarcoplasmic reticulum +
                                                        is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                part-ofsmooth endoplasmic reticulum lumen
                                                                part-ofsmooth endoplasmic reticulum membrane +
                                                                part-ofsmooth endoplasmic reticulum part +
                                                                part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular membrane-bounded organelle
                                                        is-aendoplasmic reticulum
                                                                part-ofendoplasmic reticulum part +
                                                                is-amembrane stack
                                                                is-aplasmodesmatal endoplasmic reticulum
                                                                is-arough endoplasmic reticulum +
                                                                is-asarcoplasmic reticulum +
                                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                        part-ofsmooth endoplasmic reticulum lumen
                                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                                        part-ofsmooth endoplasmic reticulum part +
                                                                        part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aendomembrane system
                                part-ofendoplasmic reticulum
                                        part-ofendoplasmic reticulum part +
                                        is-amembrane stack
                                        is-aplasmodesmatal endoplasmic reticulum
                                        is-arough endoplasmic reticulum +
                                        is-asarcoplasmic reticulum +
                                        is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                part-ofsmooth endoplasmic reticulum lumen
                                                part-ofsmooth endoplasmic reticulum membrane +
                                                part-ofsmooth endoplasmic reticulum part +
                                                part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-aendoplasmic reticulum
                                                                part-ofendoplasmic reticulum part +
                                                                is-amembrane stack
                                                                is-aplasmodesmatal endoplasmic reticulum
                                                                is-arough endoplasmic reticulum +
                                                                is-asarcoplasmic reticulum +
                                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                        part-ofsmooth endoplasmic reticulum lumen
                                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                                        part-ofsmooth endoplasmic reticulum part +
                                                                        part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasmic part
                                                is-aendoplasmic reticulum
                                                        part-ofendoplasmic reticulum part +
                                                        is-amembrane stack
                                                        is-aplasmodesmatal endoplasmic reticulum
                                                        is-arough endoplasmic reticulum +
                                                        is-asarcoplasmic reticulum +
                                                        is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                part-ofsmooth endoplasmic reticulum lumen
                                                                part-ofsmooth endoplasmic reticulum membrane +
                                                                part-ofsmooth endoplasmic reticulum part +
                                                                part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular membrane-bounded organelle
                                                        is-aendoplasmic reticulum
                                                                part-ofendoplasmic reticulum part +
                                                                is-amembrane stack
                                                                is-aplasmodesmatal endoplasmic reticulum
                                                                is-arough endoplasmic reticulum +
                                                                is-asarcoplasmic reticulum +
                                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                        part-ofsmooth endoplasmic reticulum lumen
                                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                                        part-ofsmooth endoplasmic reticulum part +
                                                                        part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasm
                                        part-ofcytoplasmic part
                                                is-aendoplasmic reticulum
                                                        part-ofendoplasmic reticulum part +
                                                        is-amembrane stack
                                                        is-aplasmodesmatal endoplasmic reticulum
                                                        is-arough endoplasmic reticulum +
                                                        is-asarcoplasmic reticulum +
                                                        is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                part-ofsmooth endoplasmic reticulum lumen
                                                                part-ofsmooth endoplasmic reticulum membrane +
                                                                part-ofsmooth endoplasmic reticulum part +
                                                                part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasmic part
                                        is-aendoplasmic reticulum
                                                part-ofendoplasmic reticulum part +
                                                is-amembrane stack
                                                is-aplasmodesmatal endoplasmic reticulum
                                                is-arough endoplasmic reticulum +
                                                is-asarcoplasmic reticulum +
                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                        part-ofsmooth endoplasmic reticulum lumen
                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                        part-ofsmooth endoplasmic reticulum part +
                                                        part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aintracellular organelle
                                        is-aintracellular membrane-bounded organelle
                                                is-aendoplasmic reticulum
                                                        part-ofendoplasmic reticulum part +
                                                        is-amembrane stack
                                                        is-aplasmodesmatal endoplasmic reticulum
                                                        is-arough endoplasmic reticulum +
                                                        is-asarcoplasmic reticulum +
                                                        is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                                part-ofsmooth endoplasmic reticulum lumen
                                                                part-ofsmooth endoplasmic reticulum membrane +
                                                                part-ofsmooth endoplasmic reticulum part +
                                                                part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-aintracellular organelle
                                is-aintracellular membrane-bounded organelle
                                        is-aendoplasmic reticulum
                                                part-ofendoplasmic reticulum part +
                                                is-amembrane stack
                                                is-aplasmodesmatal endoplasmic reticulum
                                                is-arough endoplasmic reticulum +
                                                is-asarcoplasmic reticulum +
                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                        part-ofsmooth endoplasmic reticulum lumen
                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                        part-ofsmooth endoplasmic reticulum part +
                                                        part-ofsubrhabdomeral cisterna


Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-amembrane-bounded organelle
                                is-aintracellular membrane-bounded organelle
                                        is-aendoplasmic reticulum
                                                part-ofendoplasmic reticulum part +
                                                is-amembrane stack
                                                is-aplasmodesmatal endoplasmic reticulum
                                                is-arough endoplasmic reticulum +
                                                is-asarcoplasmic reticulum +
                                                is-asmooth endoplasmic reticulum [GO:0005790] (24 genes, 24 annotations)
                                                        part-ofsmooth endoplasmic reticulum lumen
                                                        part-ofsmooth endoplasmic reticulum membrane +
                                                        part-ofsmooth endoplasmic reticulum part +
                                                        part-ofsubrhabdomeral cisterna


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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory