| GO term: | apoptotic signaling pathway |
| Synonym: | apoptotic signalling pathway |
| Synonym: | induction of apoptosis by extracellular signals |
| GO id: | GO:0097190 |
| Definition: | A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. |
| Comments | This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. |
| Number of paths to term: | 30 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processcellular processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processcellular processregulation of cellular processsignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processactivation of cysteine-type endopeptidase activity involved in apoptotic process +anoikis +apoptotic mitochondrial changes +apoptotic process involved in luteolysisapoptotic process involved in metanephric collecting duct development +apoptotic process involved in metanephric nephron tubule development +apoptotic process involved in morphogenesis +apoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +cell-type specific apoptotic process +execution phase of apoptosis +negative regulation of apoptotic process +negative regulation of cysteine-type endopeptidase activity involved in apoptotic process +negative regulation of mitochondrial membrane permeability involved in apoptotic processpositive regulation of apoptotic process +positive regulation of cysteine-type endopeptidase activity involved in apoptotic process +positive regulation of mitochondrial membrane permeability involved in apoptotic process +regulation of apoptotic process +regulation of cysteine-type endopeptidase activity involved in apoptotic process +regulation of mitochondrial membrane permeability involved in apoptotic processbiological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processcellular processsingle-organism cellular processcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processcellular processsingle-organism cellular processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processregulation of biological processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processresponse to stimuluscellular response to stimulussignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processsignalingsingle organism signalingsignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processactivation of cysteine-type endopeptidase activity involved in apoptotic process +anoikis +apoptotic mitochondrial changes +apoptotic process involved in luteolysisapoptotic process involved in metanephric collecting duct development +apoptotic process involved in metanephric nephron tubule development +apoptotic process involved in morphogenesis +apoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +cell-type specific apoptotic process +execution phase of apoptosis +negative regulation of apoptotic process +negative regulation of cysteine-type endopeptidase activity involved in apoptotic process +negative regulation of mitochondrial membrane permeability involved in apoptotic processpositive regulation of apoptotic process +positive regulation of cysteine-type endopeptidase activity involved in apoptotic process +positive regulation of mitochondrial membrane permeability involved in apoptotic process +regulation of apoptotic process +regulation of cysteine-type endopeptidase activity involved in apoptotic process +regulation of mitochondrial membrane permeability involved in apoptotic processbiological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processsingle-organism processdeathcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processsingle-organism processdeathcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processsingle-organism processsingle organism signalingsignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processactivation of cysteine-type endopeptidase activity involved in apoptotic process +anoikis +apoptotic mitochondrial changes +apoptotic process involved in luteolysisapoptotic process involved in metanephric collecting duct development +apoptotic process involved in metanephric nephron tubule development +apoptotic process involved in morphogenesis +apoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +cell-type specific apoptotic process +execution phase of apoptosis +negative regulation of apoptotic process +negative regulation of cysteine-type endopeptidase activity involved in apoptotic process +negative regulation of mitochondrial membrane permeability involved in apoptotic processpositive regulation of apoptotic process +positive regulation of cysteine-type endopeptidase activity involved in apoptotic process +positive regulation of mitochondrial membrane permeability involved in apoptotic process +regulation of apoptotic process +regulation of cysteine-type endopeptidase activity involved in apoptotic process +regulation of mitochondrial membrane permeability involved in apoptotic processbiological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processsingle-organism processsingle-organism cellular processcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +carbohydrate mediated signaling +cell surface receptor signaling pathway +chloroplast-nucleus signaling pathwaydefense response signaling pathway, resistance gene-dependentdefense response signaling pathway, resistance gene-independentER-nucleus signaling pathway +hormone-mediated signaling pathway +hydrogen peroxide mediated signaling pathway +hypoxia-inducible factor-1alpha signaling pathway +immune response-regulating signaling pathway +intracellular receptor signaling pathway +intracellular signal transduction +lipoprotein particle mediated signaling +mitochondria-nucleus signaling pathwaynegative regulation of signal transduction +neuronal signal transductionosmosensory signaling pathway +phosphorelay signal transduction system +phototransduction +positive regulation of signal transduction +red or far-red light signaling pathway +regulation of blood pressure by chemoreceptor signaling pathway +regulation of floral organ abscission by signal transduction +regulation of signal transduction +salicylic acid mediated signaling pathway +signal transduction by conformational transitionsignal transduction by phosphorylation +signal transduction in absence of ligand +signal transduction involved in conjugation with cellular fusion +signal transduction involved in filamentous growthsignal transduction involved in regulation of gene expressionSMAD protein signal transductionsphingolipid mediated signaling pathway +biological_processsingle-organism processsingle-organism cellular processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathway [GO:0097190] (213 genes, 348 annotations)apoptosome assemblyextrinsic apoptotic signaling pathway +granzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +negative regulation of execution phase of apoptosispositive regulation of execution phase of apoptosisregulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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