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Gene Ontology Browser
Term Detail
GO term:apoptotic signaling pathway
Synonym: apoptotic signalling pathway
Synonym: induction of apoptosis by extracellular signals
GO id:GO:0097190
Definition:A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
CommentsThis term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
Number of paths to term: 12

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes +
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes +
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofactivation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        is-aanoikis +
                                                        part-ofapoptotic mitochondrial changes +
                                                        is-aapoptotic process involved in development +
                                                        part-ofapoptotic signaling pathway [GO:0097190] (528 genes, 902 annotations)
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway +
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +
                                                        is-acell-type specific apoptotic process +
                                                        part-ofexecution phase of apoptosis +
                                                        negatively-regulatesnegative regulation of apoptotic process +
                                                        part-ofnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofnegative regulation of mitochondrial membrane permeability involved in apoptotic process
                                                        positively-regulatespositive regulation of apoptotic process +
                                                        part-ofpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofpositive regulation of mitochondrial membrane permeability involved in apoptotic process +
                                                        regulatesregulation of apoptotic process +
                                                        part-ofregulation of cysteine-type endopeptidase activity involved in apoptotic process +
                                                        part-ofregulation of mitochondrial membrane permeability involved in apoptotic process +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory