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Gene Ontology Browser
Term Detail
GO term:membrane protein ectodomain proteolysis
Synonym: ectodomain cleavage
Synonym: membrane protein solubilization
Synonym: receptor shedding
GO id:GO:0006509
Definition:The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-aprotein metabolic process
                                                is-aproteolysis
                                                        is-amembrane protein proteolysis
                                                                is-amembrane protein ectodomain proteolysis [GO:0006509] (33 genes, 45 annotations)
                                                                        is-aconstitutive protein ectodomain proteolysis
                                                                        negatively-regulatesnegative regulation of membrane protein ectodomain proteolysis
                                                                        is-aPMA-inducible membrane protein ectodomain proteolysis
                                                                        positively-regulatespositive regulation of membrane protein ectodomain proteolysis
                                                                        regulatesregulation of membrane protein ectodomain proteolysis +
                                                                is-amembrane protein intracellular domain proteolysis +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aprimary metabolic process
                                is-aprotein metabolic process
                                        is-aproteolysis
                                                is-amembrane protein proteolysis
                                                        is-amembrane protein ectodomain proteolysis [GO:0006509] (33 genes, 45 annotations)
                                                                is-aconstitutive protein ectodomain proteolysis
                                                                negatively-regulatesnegative regulation of membrane protein ectodomain proteolysis
                                                                is-aPMA-inducible membrane protein ectodomain proteolysis
                                                                positively-regulatespositive regulation of membrane protein ectodomain proteolysis
                                                                regulatesregulation of membrane protein ectodomain proteolysis +
                                                        is-amembrane protein intracellular domain proteolysis +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory