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Gene Ontology Browser
Term Detail
GO term:synapse
Synonym: electrotonic synapse
Synonym: mixed synapse
Synonym: synaptic junction
GO id:GO:0045202
Definition:The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-acell +
                is-acell junction +
                is-acell part +
                is-aextracellular region +
                is-aextracellular region part +
                is-amacromolecular complex +
                is-amembrane +
                is-amembrane part +
                is-amembrane-enclosed lumen +
                is-amitochondrion-associated adherens complex
                is-anucleoid +
                is-aorganelle +
                is-aorganelle part +
                is-aother organism +
                is-aother organism part +
                is-asupramolecular complex +
                is-asymplast +
                is-asynapse [GO:0045202] (905 genes, 2076 annotations)
                        is-acholinergic synapse +
                        is-aexcitatory synapse +
                        is-aGABA-ergic synapse +
                        is-aglutamatergic synapse +
                        is-ahippocampal mossy fiber to CA3 synapse
                        is-ainhibitory synapse +
                        is-aneuromuscular junction +
                        is-aneuron to neuron synapse +
                        is-apolyadic synapse
                        part-ofpostsynapse +
                        part-ofpresynapse +
                        is-aribbon synapse +
                        is-aSchaffer collateral - CA1 synapse
                        part-ofsynapse part +
                        part-ofsynaptic cleft +
                        part-ofsynaptic membrane +
                is-asynapse part +
                is-aviral occlusion body
                is-avirion +
                is-avirion part +

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory