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Gene Ontology Browser
Term Detail
GO term:regulation of gene expression
Synonym: regulation of gene product expression
Synonym: regulation of protein expression
GO id:GO:0010468
Definition:Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of macromolecule metabolic process
                                                is-agenetic imprinting +
                                                is-anegative regulation of macromolecule metabolic process +
                                                is-apositive regulation of macromolecule metabolic process +
                                                is-aregulation of amylopectin metabolic process +
                                                is-aregulation of cell wall macromolecule metabolic process +
                                                is-aregulation of cellular carbohydrate catabolic process +
                                                is-aregulation of collagen metabolic process +
                                                is-aregulation of DNA metabolic process +
                                                is-aregulation of gene expression [GO:0010468] (3782 genes, 9235 annotations)
                                                        is-acircadian regulation of gene expression
                                                        is-amodulation by virus of host gene expression +
                                                        is-anegative regulation of gene expression +
                                                        is-apositive regulation of gene expression +
                                                        is-aposttranscriptional regulation of gene expression +
                                                        is-apre-B cell allelic exclusion
                                                        is-aregulation of gene expression involved in extracellular matrix organization +
                                                        is-aregulation of gene expression, epigenetic +
                                                        is-aregulation of histone gene expression +
                                                        is-aregulation of mRNA export from nucleus +
                                                        is-aregulation of mRNA processing +
                                                        is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                        is-aregulation of protein maturation +
                                                        is-aregulation of rhodopsin gene expression +
                                                        is-aregulation of RNA splicing +
                                                        is-aregulation of rRNA processing +
                                                        is-aregulation of snoRNA processing +
                                                        is-aregulation of transcription, DNA-templated +
                                                        is-aregulation of tRNA processing +
                                                        is-aregulation of viral transcription +
                                                        part-ofsignal transduction involved in regulation of gene expression +
                                                is-aregulation of macromolecule biosynthetic process +
                                                is-aregulation of meiotic DNA double-strand break formation +
                                                is-aregulation of nuclease activity +
                                                is-aregulation of phosphatidylinositol dephosphorylation
                                                is-aregulation of polynucleotide 3'-phosphatase activity +
                                                is-aregulation of polysaccharide metabolic process +
                                                is-aregulation of protein metabolic process +
                                                is-aregulation of receptor catabolic process +
                                                is-aregulation of receptor internalization +
                                                is-aregulation of receptor recycling +
                                                is-aregulation of RNA metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-agene expression
                                                is-agene expression involved in extracellular matrix organization +
                                                part-ofmRNA export from nucleus +
                                                negatively-regulatesnegative regulation of gene expression +
                                                positively-regulatespositive regulation of gene expression +
                                                is-apre-B cell receptor expression
                                                part-ofprotein maturation +
                                                regulatesregulation of gene expression [GO:0010468] (3782 genes, 9235 annotations)
                                                        is-acircadian regulation of gene expression
                                                        is-amodulation by virus of host gene expression +
                                                        is-anegative regulation of gene expression +
                                                        is-apositive regulation of gene expression +
                                                        is-aposttranscriptional regulation of gene expression +
                                                        is-apre-B cell allelic exclusion
                                                        is-aregulation of gene expression involved in extracellular matrix organization +
                                                        is-aregulation of gene expression, epigenetic +
                                                        is-aregulation of histone gene expression +
                                                        is-aregulation of mRNA export from nucleus +
                                                        is-aregulation of mRNA processing +
                                                        is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                        is-aregulation of protein maturation +
                                                        is-aregulation of rhodopsin gene expression +
                                                        is-aregulation of RNA splicing +
                                                        is-aregulation of rRNA processing +
                                                        is-aregulation of snoRNA processing +
                                                        is-aregulation of transcription, DNA-templated +
                                                        is-aregulation of tRNA processing +
                                                        is-aregulation of viral transcription +
                                                        part-ofsignal transduction involved in regulation of gene expression +
                                                part-ofRNA processing +
                                                part-oftranscription, DNA-templated +
                                                part-oftranslation +
                                                is-aviral gene expression +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        regulatesregulation of macromolecule metabolic process
                                                is-agenetic imprinting +
                                                is-anegative regulation of macromolecule metabolic process +
                                                is-apositive regulation of macromolecule metabolic process +
                                                is-aregulation of amylopectin metabolic process +
                                                is-aregulation of cell wall macromolecule metabolic process +
                                                is-aregulation of cellular carbohydrate catabolic process +
                                                is-aregulation of collagen metabolic process +
                                                is-aregulation of DNA metabolic process +
                                                is-aregulation of gene expression [GO:0010468] (3782 genes, 9235 annotations)
                                                        is-acircadian regulation of gene expression
                                                        is-amodulation by virus of host gene expression +
                                                        is-anegative regulation of gene expression +
                                                        is-apositive regulation of gene expression +
                                                        is-aposttranscriptional regulation of gene expression +
                                                        is-apre-B cell allelic exclusion
                                                        is-aregulation of gene expression involved in extracellular matrix organization +
                                                        is-aregulation of gene expression, epigenetic +
                                                        is-aregulation of histone gene expression +
                                                        is-aregulation of mRNA export from nucleus +
                                                        is-aregulation of mRNA processing +
                                                        is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                        is-aregulation of protein maturation +
                                                        is-aregulation of rhodopsin gene expression +
                                                        is-aregulation of RNA splicing +
                                                        is-aregulation of rRNA processing +
                                                        is-aregulation of snoRNA processing +
                                                        is-aregulation of transcription, DNA-templated +
                                                        is-aregulation of tRNA processing +
                                                        is-aregulation of viral transcription +
                                                        part-ofsignal transduction involved in regulation of gene expression +
                                                is-aregulation of macromolecule biosynthetic process +
                                                is-aregulation of meiotic DNA double-strand break formation +
                                                is-aregulation of nuclease activity +
                                                is-aregulation of phosphatidylinositol dephosphorylation
                                                is-aregulation of polynucleotide 3'-phosphatase activity +
                                                is-aregulation of polysaccharide metabolic process +
                                                is-aregulation of protein metabolic process +
                                                is-aregulation of receptor catabolic process +
                                                is-aregulation of receptor internalization +
                                                is-aregulation of receptor recycling +
                                                is-aregulation of RNA metabolic process +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-agenetic imprinting +
                                        is-anegative regulation of macromolecule metabolic process +
                                        is-apositive regulation of macromolecule metabolic process +
                                        is-aregulation of amylopectin metabolic process +
                                        is-aregulation of cell wall macromolecule metabolic process +
                                        is-aregulation of cellular carbohydrate catabolic process +
                                        is-aregulation of collagen metabolic process +
                                        is-aregulation of DNA metabolic process +
                                        is-aregulation of gene expression [GO:0010468] (3782 genes, 9235 annotations)
                                                is-acircadian regulation of gene expression
                                                is-amodulation by virus of host gene expression +
                                                is-anegative regulation of gene expression +
                                                is-apositive regulation of gene expression +
                                                is-aposttranscriptional regulation of gene expression +
                                                is-apre-B cell allelic exclusion
                                                is-aregulation of gene expression involved in extracellular matrix organization +
                                                is-aregulation of gene expression, epigenetic +
                                                is-aregulation of histone gene expression +
                                                is-aregulation of mRNA export from nucleus +
                                                is-aregulation of mRNA processing +
                                                is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                is-aregulation of protein maturation +
                                                is-aregulation of rhodopsin gene expression +
                                                is-aregulation of RNA splicing +
                                                is-aregulation of rRNA processing +
                                                is-aregulation of snoRNA processing +
                                                is-aregulation of transcription, DNA-templated +
                                                is-aregulation of tRNA processing +
                                                is-aregulation of viral transcription +
                                                part-ofsignal transduction involved in regulation of gene expression +
                                        is-aregulation of macromolecule biosynthetic process +
                                        is-aregulation of meiotic DNA double-strand break formation +
                                        is-aregulation of nuclease activity +
                                        is-aregulation of phosphatidylinositol dephosphorylation
                                        is-aregulation of polynucleotide 3'-phosphatase activity +
                                        is-aregulation of polysaccharide metabolic process +
                                        is-aregulation of protein metabolic process +
                                        is-aregulation of receptor catabolic process +
                                        is-aregulation of receptor internalization +
                                        is-aregulation of receptor recycling +
                                        is-aregulation of RNA metabolic process +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-agenetic imprinting +
                                        is-anegative regulation of macromolecule metabolic process +
                                        is-apositive regulation of macromolecule metabolic process +
                                        is-aregulation of amylopectin metabolic process +
                                        is-aregulation of cell wall macromolecule metabolic process +
                                        is-aregulation of cellular carbohydrate catabolic process +
                                        is-aregulation of collagen metabolic process +
                                        is-aregulation of DNA metabolic process +
                                        is-aregulation of gene expression [GO:0010468] (3782 genes, 9235 annotations)
                                                is-acircadian regulation of gene expression
                                                is-amodulation by virus of host gene expression +
                                                is-anegative regulation of gene expression +
                                                is-apositive regulation of gene expression +
                                                is-aposttranscriptional regulation of gene expression +
                                                is-apre-B cell allelic exclusion
                                                is-aregulation of gene expression involved in extracellular matrix organization +
                                                is-aregulation of gene expression, epigenetic +
                                                is-aregulation of histone gene expression +
                                                is-aregulation of mRNA export from nucleus +
                                                is-aregulation of mRNA processing +
                                                is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                is-aregulation of protein maturation +
                                                is-aregulation of rhodopsin gene expression +
                                                is-aregulation of RNA splicing +
                                                is-aregulation of rRNA processing +
                                                is-aregulation of snoRNA processing +
                                                is-aregulation of transcription, DNA-templated +
                                                is-aregulation of tRNA processing +
                                                is-aregulation of viral transcription +
                                                part-ofsignal transduction involved in regulation of gene expression +
                                        is-aregulation of macromolecule biosynthetic process +
                                        is-aregulation of meiotic DNA double-strand break formation +
                                        is-aregulation of nuclease activity +
                                        is-aregulation of phosphatidylinositol dephosphorylation
                                        is-aregulation of polynucleotide 3'-phosphatase activity +
                                        is-aregulation of polysaccharide metabolic process +
                                        is-aregulation of protein metabolic process +
                                        is-aregulation of receptor catabolic process +
                                        is-aregulation of receptor internalization +
                                        is-aregulation of receptor recycling +
                                        is-aregulation of RNA metabolic process +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory