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Gene Ontology Browser
Term Detail
GO term:regulation of gene expression
Synonym: regulation of gene product expression
Synonym: regulation of protein expression
GO id:GO:0010468
Definition:Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene''s coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA trnscript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
CommentsThis class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availabiliy of mRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of metabolic process
                                        is-aregulation of macromolecule metabolic process
                                                is-agenetic imprinting +
                                                is-anegative regulation of macromolecule metabolic process +
                                                is-apositive regulation of macromolecule metabolic process +
                                                is-aregulation of amylopectin metabolic process +
                                                is-aregulation of cell wall macromolecule metabolic process +
                                                is-aregulation of cellular carbohydrate catabolic process +
                                                is-aregulation of collagen metabolic process +
                                                is-aregulation of DNA metabolic process +
                                                is-aregulation of gene expression [GO:0010468] (3683 genes, 9497 annotations)
                                                        is-acircadian regulation of gene expression
                                                        is-amodulation by virus of host gene expression +
                                                        is-anegative regulation of gene expression +
                                                        is-apositive regulation of gene expression +
                                                        is-aposttranscriptional regulation of gene expression +
                                                        is-apre-B cell allelic exclusion
                                                        is-aregulation of gene expression, epigenetic +
                                                        is-aregulation of histone gene expression +
                                                        is-aregulation of mRNA export from nucleus +
                                                        is-aregulation of mRNA processing +
                                                        is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                        is-aregulation of protein maturation +
                                                        is-aregulation of rhodopsin gene expression +
                                                        is-aregulation of RNA splicing +
                                                        is-aregulation of rRNA processing +
                                                        is-aregulation of snoRNA processing +
                                                        is-aregulation of transcription, DNA-templated +
                                                        is-aregulation of tRNA processing +
                                                        is-aregulation of viral transcription +
                                                        part-ofsignal transduction involved in regulation of gene expression +
                                                is-aregulation of macromolecule biosynthetic process +
                                                is-aregulation of meiotic DNA double-strand break formation +
                                                is-aregulation of nuclease activity +
                                                is-aregulation of phosphatidylinositol dephosphorylation
                                                is-aregulation of polynucleotide 3'-phosphatase activity +
                                                is-aregulation of polysaccharide metabolic process +
                                                is-aregulation of protein metabolic process +
                                                is-aregulation of receptor catabolic process +
                                                is-aregulation of receptor internalization +
                                                is-aregulation of receptor recycling +
                                                is-aregulation of RNA metabolic process +


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        is-agene expression
                                                is-agene expression involved in extracellular matrix organization
                                                part-ofmRNA export from nucleus +
                                                negatively-regulatesnegative regulation of gene expression +
                                                positively-regulatespositive regulation of gene expression +
                                                is-apre-B cell receptor expression
                                                part-ofprotein maturation +
                                                regulatesregulation of gene expression [GO:0010468] (3683 genes, 9497 annotations)
                                                        is-acircadian regulation of gene expression
                                                        is-amodulation by virus of host gene expression +
                                                        is-anegative regulation of gene expression +
                                                        is-apositive regulation of gene expression +
                                                        is-aposttranscriptional regulation of gene expression +
                                                        is-apre-B cell allelic exclusion
                                                        is-aregulation of gene expression, epigenetic +
                                                        is-aregulation of histone gene expression +
                                                        is-aregulation of mRNA export from nucleus +
                                                        is-aregulation of mRNA processing +
                                                        is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                        is-aregulation of protein maturation +
                                                        is-aregulation of rhodopsin gene expression +
                                                        is-aregulation of RNA splicing +
                                                        is-aregulation of rRNA processing +
                                                        is-aregulation of snoRNA processing +
                                                        is-aregulation of transcription, DNA-templated +
                                                        is-aregulation of tRNA processing +
                                                        is-aregulation of viral transcription +
                                                        part-ofsignal transduction involved in regulation of gene expression +
                                                regulatesregulation of gene expression by genetic imprinting +
                                                part-ofRNA processing +
                                                part-oftranscription, DNA-templated +
                                                part-oftranslation +
                                                is-aviral gene expression +


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-aorganic substance metabolic process
                                is-amacromolecule metabolic process
                                        regulatesregulation of macromolecule metabolic process
                                                is-agenetic imprinting +
                                                is-anegative regulation of macromolecule metabolic process +
                                                is-apositive regulation of macromolecule metabolic process +
                                                is-aregulation of amylopectin metabolic process +
                                                is-aregulation of cell wall macromolecule metabolic process +
                                                is-aregulation of cellular carbohydrate catabolic process +
                                                is-aregulation of collagen metabolic process +
                                                is-aregulation of DNA metabolic process +
                                                is-aregulation of gene expression [GO:0010468] (3683 genes, 9497 annotations)
                                                        is-acircadian regulation of gene expression
                                                        is-amodulation by virus of host gene expression +
                                                        is-anegative regulation of gene expression +
                                                        is-apositive regulation of gene expression +
                                                        is-aposttranscriptional regulation of gene expression +
                                                        is-apre-B cell allelic exclusion
                                                        is-aregulation of gene expression, epigenetic +
                                                        is-aregulation of histone gene expression +
                                                        is-aregulation of mRNA export from nucleus +
                                                        is-aregulation of mRNA processing +
                                                        is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                        is-aregulation of protein maturation +
                                                        is-aregulation of rhodopsin gene expression +
                                                        is-aregulation of RNA splicing +
                                                        is-aregulation of rRNA processing +
                                                        is-aregulation of snoRNA processing +
                                                        is-aregulation of transcription, DNA-templated +
                                                        is-aregulation of tRNA processing +
                                                        is-aregulation of viral transcription +
                                                        part-ofsignal transduction involved in regulation of gene expression +
                                                is-aregulation of macromolecule biosynthetic process +
                                                is-aregulation of meiotic DNA double-strand break formation +
                                                is-aregulation of nuclease activity +
                                                is-aregulation of phosphatidylinositol dephosphorylation
                                                is-aregulation of polynucleotide 3'-phosphatase activity +
                                                is-aregulation of polysaccharide metabolic process +
                                                is-aregulation of protein metabolic process +
                                                is-aregulation of receptor catabolic process +
                                                is-aregulation of receptor internalization +
                                                is-aregulation of receptor recycling +
                                                is-aregulation of RNA metabolic process +


obsolete Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        regulatesregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-agenetic imprinting +
                                        is-anegative regulation of macromolecule metabolic process +
                                        is-apositive regulation of macromolecule metabolic process +
                                        is-aregulation of amylopectin metabolic process +
                                        is-aregulation of cell wall macromolecule metabolic process +
                                        is-aregulation of cellular carbohydrate catabolic process +
                                        is-aregulation of collagen metabolic process +
                                        is-aregulation of DNA metabolic process +
                                        is-aregulation of gene expression [GO:0010468] (3683 genes, 9497 annotations)
                                                is-acircadian regulation of gene expression
                                                is-amodulation by virus of host gene expression +
                                                is-anegative regulation of gene expression +
                                                is-apositive regulation of gene expression +
                                                is-aposttranscriptional regulation of gene expression +
                                                is-apre-B cell allelic exclusion
                                                is-aregulation of gene expression, epigenetic +
                                                is-aregulation of histone gene expression +
                                                is-aregulation of mRNA export from nucleus +
                                                is-aregulation of mRNA processing +
                                                is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                is-aregulation of protein maturation +
                                                is-aregulation of rhodopsin gene expression +
                                                is-aregulation of RNA splicing +
                                                is-aregulation of rRNA processing +
                                                is-aregulation of snoRNA processing +
                                                is-aregulation of transcription, DNA-templated +
                                                is-aregulation of tRNA processing +
                                                is-aregulation of viral transcription +
                                                part-ofsignal transduction involved in regulation of gene expression +
                                        is-aregulation of macromolecule biosynthetic process +
                                        is-aregulation of meiotic DNA double-strand break formation +
                                        is-aregulation of nuclease activity +
                                        is-aregulation of phosphatidylinositol dephosphorylation
                                        is-aregulation of polynucleotide 3'-phosphatase activity +
                                        is-aregulation of polysaccharide metabolic process +
                                        is-aregulation of protein metabolic process +
                                        is-aregulation of receptor catabolic process +
                                        is-aregulation of receptor internalization +
                                        is-aregulation of receptor recycling +
                                        is-aregulation of RNA metabolic process +


obsolete Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of metabolic process
                                is-aregulation of macromolecule metabolic process
                                        is-agenetic imprinting +
                                        is-anegative regulation of macromolecule metabolic process +
                                        is-apositive regulation of macromolecule metabolic process +
                                        is-aregulation of amylopectin metabolic process +
                                        is-aregulation of cell wall macromolecule metabolic process +
                                        is-aregulation of cellular carbohydrate catabolic process +
                                        is-aregulation of collagen metabolic process +
                                        is-aregulation of DNA metabolic process +
                                        is-aregulation of gene expression [GO:0010468] (3683 genes, 9497 annotations)
                                                is-acircadian regulation of gene expression
                                                is-amodulation by virus of host gene expression +
                                                is-anegative regulation of gene expression +
                                                is-apositive regulation of gene expression +
                                                is-aposttranscriptional regulation of gene expression +
                                                is-apre-B cell allelic exclusion
                                                is-aregulation of gene expression, epigenetic +
                                                is-aregulation of histone gene expression +
                                                is-aregulation of mRNA export from nucleus +
                                                is-aregulation of mRNA processing +
                                                is-aregulation of production of small RNA involved in gene silencing by RNA +
                                                is-aregulation of protein maturation +
                                                is-aregulation of rhodopsin gene expression +
                                                is-aregulation of RNA splicing +
                                                is-aregulation of rRNA processing +
                                                is-aregulation of snoRNA processing +
                                                is-aregulation of transcription, DNA-templated +
                                                is-aregulation of tRNA processing +
                                                is-aregulation of viral transcription +
                                                part-ofsignal transduction involved in regulation of gene expression +
                                        is-aregulation of macromolecule biosynthetic process +
                                        is-aregulation of meiotic DNA double-strand break formation +
                                        is-aregulation of nuclease activity +
                                        is-aregulation of phosphatidylinositol dephosphorylation
                                        is-aregulation of polynucleotide 3'-phosphatase activity +
                                        is-aregulation of polysaccharide metabolic process +
                                        is-aregulation of protein metabolic process +
                                        is-aregulation of receptor catabolic process +
                                        is-aregulation of receptor internalization +
                                        is-aregulation of receptor recycling +
                                        is-aregulation of RNA metabolic process +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory