| GO term: | Notch signaling pathway |
| Synonym: | Notch receptor signaling pathway |
| Synonym: | Notch-receptor signaling pathway |
| Synonym: | Notch receptor signalling pathway |
| Synonym: | Notch-receptor signalling pathway |
| Synonym: | Notch signalling pathway |
| Synonym: | N signaling pathway |
| Synonym: | N signalling pathway |
| GO id: | GO:0007219 |
| Definition: | A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
| Number of paths to term: | 10 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processresponse to stimuluscellular response to stimulussignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processsignalingsingle organism signalingsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway +Fas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway [GO:0007219] (100 genes, 161 annotations)negative regulation of Notch signaling pathwayNotch receptor processing, ligand-dependentNotch signaling involved in heart development +Notch signaling pathway involved in arterial endothelial cell fate commitmentNotch signaling pathway involved in camera-type eye photoreceptor fate commitmentNotch signaling pathway involved in forebrain neuroblast divisionNotch signaling pathway involved in forebrain neuron fate commitmentNotch signaling pathway involved in negative regulation of venous endothelial cell fate commitmentpositive regulation of Notch signaling pathway +positive regulation of transcription of Notch receptor targetregulation of Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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