| GO term: | negative regulation of protein kinase activity |
| Synonym: | down regulation of protein kinase activity |
| Synonym: | down-regulation of protein kinase activity |
| Synonym: | downregulation of protein kinase activity |
| Synonym: | inhibition of protein kinase activity |
| GO id: | GO:0006469 |
| Definition: | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. |
| Number of paths to term: | 346 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of cellular processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of cellular processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of metabolic processnegative regulation of macromolecule metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processnegative regulation of cellular processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processnegative regulation of cellular processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activityregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processnegative regulation of metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processnegative regulation of metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processnegative regulation of metabolic processnegative regulation of macromolecule metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activitynegative regulation of catalytic activitynegative regulation of transferase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of transferase activitynegative regulation of transferase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of transferase activityregulation of kinase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of transferase activityregulation of kinase activityregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activityregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processnegative regulation of macromolecule metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of molecular functionnegative regulation of molecular functionnegative regulation of catalytic activitynegative regulation of transferase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of molecular functionregulation of catalytic activitynegative regulation of catalytic activitynegative regulation of transferase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of molecular functionregulation of catalytic activityregulation of transferase activitynegative regulation of transferase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of molecular functionregulation of catalytic activityregulation of transferase activityregulation of kinase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processbiological regulationregulation of molecular functionregulation of catalytic activityregulation of transferase activityregulation of kinase activityregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein phosphorylationregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processprotein phosphorylationregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processcellular protein modification processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processcellular macromolecule metabolic processcellular protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationprotein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationprotein phosphorylationregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationprotein phosphorylationregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationregulation of phosphorylationnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylationnegative regulation of peptidyl-serine phosphorylation +negative regulation of peptidyl-threonine phosphorylationnegative regulation of peptidyl-tyrosine phosphorylation +negative regulation of phosphorylation of RNA polymerase II C-terminal domain +negative regulation of protein autophosphorylation +negative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationregulation of phosphorylationregulation of kinase activitynegative regulation of kinase activitynegative regulation of glucokinase activitynegative regulation of lipid kinase activity +negative regulation of NAD+ kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationregulation of phosphorylationregulation of kinase activityregulation of protein kinase activitynegative regulation of protein kinase activity [GO:0006469] (146 genes, 187 annotations)inactivation of MAPKK activitynegative regulation of protein histidine kinase activitynegative regulation of protein kinase activity by regulation of protein phosphorylationnegative regulation of protein serine/threonine kinase activity +negative regulation of protein tyrosine kinase activity +positive regulation of protein kinase activity +regulation of protein histidine kinase activity +regulation of protein serine/threonine kinase activity +regulation of protein tyrosine kinase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processphosphorylationregulation of phosphorylationregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of histone phosphorylationnegative regulation of pathway-restricted SMAD protein phosphorylation
Analysis Tools