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Term Detail
GO term:response to hypoxia
Synonym: response to hypoxic stress
Synonym: response to intermittent hypoxia
Synonym: response to lowered oxygen tension
Synonym: response to sustained hypoxia
GO id:GO:0001666
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
CommentsNote that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                is-aresponse to stimulus
                        is-aresponse to abiotic stimulus
                                is-aresponse to oxygen levels
                                        is-aresponse to decreased oxygen levels
                                                is-acellular response to decreased oxygen levels +
                                                is-aresponse to anoxia +
                                                is-aresponse to hypoxia [GO:0001666] (189 genes, 241 annotations)
                                                        is-acellular response to hypoxia +
                                                        is-adetection of hypoxia +
                                                        is-aresponse to hypobaric hypoxia
                                                is-aresponse to oxygen-glucose deprivation +

                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress +
                                is-adefense response +
                                is-amulticellular organismal response to stress +
                                is-amuscle hypertrophy in response to stress +
                                is-aphage shock
                                regulatesregulation of response to stress +
                                is-aresponse to anoxia +
                                is-aresponse to caloric restriction +
                                is-aresponse to cold +
                                is-aresponse to flooding
                                is-aresponse to fluid shear stress +
                                is-aresponse to heat +
                                is-aresponse to herbicide
                                is-aresponse to high population density
                                is-aresponse to hydrostatic pressure +
                                is-aresponse to hyperoxia +
                                is-aresponse to hypoxia [GO:0001666] (189 genes, 241 annotations)
                                        is-acellular response to hypoxia +
                                        is-adetection of hypoxia +
                                        is-aresponse to hypobaric hypoxia
                                is-aresponse to immobilization stress +
                                is-aresponse to ischemia
                                is-aresponse to isolation stress +
                                is-aresponse to nitrosative stress +
                                is-aresponse to osmotic stress +
                                is-aresponse to oxidative stress +
                                is-aresponse to psychosocial stress
                                is-aresponse to starvation +
                                is-aresponse to sterol depletion +
                                is-aresponse to topologically incorrect protein +
                                is-aresponse to water deprivation +
                                is-aresponse to wounding +
                                is-astress response to acid chemical +
                                is-astress response to metal ion +

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
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