| GO term: | response to hypoxia |
| Synonym: | response to hypoxic stress |
| Synonym: | response to lowered oxygen tension |
| GO id: | GO:0001666 |
| Definition: | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| Comments | Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. |
| Number of paths to term: | 2 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processresponse to stimulusresponse to abiotic stimulusresponse to oxygen levelsresponse to decreased oxygen levelscellular response to decreased oxygen levels +response to anoxia +response to hypoxia [GO:0001666] (133 genes, 161 annotations)cellular response to hypoxia +detection of hypoxia +biological_processresponse to stimulusresponse to stresscellular response to stress +defense response +multicellular organismal response to stress +muscle hypertrophy in response to stress +phage shockregulation of response to stress +response to anoxia +response to cold +response to floodingresponse to fluid shear stress +response to heat +response to herbicideresponse to hydrostatic pressure +response to hyperoxia +response to hypoxia [GO:0001666] (133 genes, 161 annotations)cellular response to hypoxia +detection of hypoxia +response to immobilization stress +response to ischemiaresponse to isolation stress +response to nitrosative stress +response to osmotic stress +response to oxidative stress +response to starvation +response to sterol depletion +response to topologically incorrect protein +response to water deprivation +response to wounding +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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