| GO term: | canonical Wnt receptor signaling pathway |
| Synonym: | canonical Wnt signaling pathway |
| Synonym: | frizzled-1 receptor signaling pathway |
| Synonym: | Wnt receptor signaling pathway through beta-catenin |
| Synonym: | Wnt receptor signaling pathway via beta-catenin |
| Synonym: | Wnt receptor signalling pathway through beta-catenin |
| GO id: | GO:0060070 |
| Definition: | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| Number of paths to term: | 10 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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