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Gene Ontology Browser
Term Detail
GO term:neuromuscular junction
Synonym: motor endplate
Synonym: NMJ
GO id:GO:0031594
Definition:The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
CommentsIn vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship

                        is-acholinergic synapse +
                        is-adopaminergic synapse
                        is-aexcitatory synapse +
                        is-aGABA-ergic synapse +
                        is-aglutamatergic synapse +
                        is-aglycinergic synapse
                        is-ahippocampal mossy fiber to CA3 synapse
                        is-ainhibitory synapse +
                        is-aneuromuscular junction [GO:0031594] (67 genes, 74 annotations)
                                is-aexcitatory neuromuscular junction +
                                is-ainhibitory neuromuscular junction +
                                is-aneuromuscular junction of myotube +
                                is-aneuromuscular junction of somatic muscle +
                                part-ofpostsynapse of neuromuscular junction +
                        is-aneuron to neuron synapse +
                        is-anoradrenergic synapse
                        is-apolyadic synapse
                        is-aribbon synapse +
                        is-aSchaffer collateral - CA1 synapse
                        part-ofsynapse part +

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory