Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse P2rx7

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes P2RX7
- Mouse genes P2rx7
- Rat genes P2rx7
- Zfish genes p2rx7
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set P2rx7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12677010
Molecular Function	GO:0005524	ATP binding	P2rx7	IDA		Rat	PMID:17394459\|RGD:1642698
Molecular Function	GO:0035381	ATP-gated ion channel activity	p2rx7	IDA		Zfish	PMID:25645917
Molecular Function	GO:0015267	channel activity	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18519738
Molecular Function	GO:0015267	channel activity	P2rx7	IDA		Rat	PMID:18519738\|RGD:8554572
Molecular Function	GO:0005507	copper ion binding	P2rx7	IDA		Rat	PMID:17394459\|RGD:1642698
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2RX7	IDA		Human	PMID:9038151
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12677010
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx7	IMP		Mouse	PMID:15713258
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx7	IDA		Rat	PMID:17394459\|RGD:1642698
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	P2rx7	IDA		Rat	PMID:8614837\|RGD:69918
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx7	IDA		Zfish	PMID:16837047
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	p2rx7	IDA		Zfish	PMID:14580944
Molecular Function	GO:0042802	identical protein binding	P2rx7	IPI	PR:Q9Z1M0	Mouse	PMID:15713258
Molecular Function	GO:0042802	identical protein binding	P2rx7	IPI	UniProtKB:Q64663	Rat	PMID:18938136\|RGD:15023488
Molecular Function	GO:0001530	lipopolysaccharide binding	P2rx7	IDA		Mouse	PMID:11489964
Molecular Function	GO:0000287	magnesium ion binding	P2rx7	IDA		Rat	PMID:17394459\|RGD:1642698
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:P54849	Human	PMID:12107182
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:P54851	Human	PMID:12107182
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:P54852	Human	PMID:12107182
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:Q01453	Human	PMID:12107182
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:Q4KMQ2	Human	PMID:25651887
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:O95967	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:P14373	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:Q8N720	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2RX7	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	P2rx7	IPI	PR:P23242	Mouse	PMID:15331634
Molecular Function	GO:0005515	protein binding	P2rx7	IPI	UniProtKB:Q96RD7	Rat	PMID:17036048\|RGD:8554591
Molecular Function	GO:0005515	protein binding	P2rx7	IPI	RGD:735204	Rat	PMID:19416975\|RGD:5491011
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	P2rx7	IMP		Rat	PMID:15023862\|RGD:1642719
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	P2RX7	IDA		Human	PMID:9038151
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	P2rx7	IDA		Rat	PMID:8614837\|RGD:69918
Molecular Function	GO:0097110	scaffold protein binding	P2rx7	IPI	RGD:628637	Rat	PMID:19416975\|RGD:5491011
Molecular Function	GO:0038023	signaling receptor activity	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12677010
Molecular Function	GO:0005102	signaling receptor binding	P2rx7	IPI	UniProtKB:P51577	Rat	PMID:17785580\|RGD:8554639
Molecular Function	GO:0008270	zinc ion binding	P2rx7	IDA		Rat	PMID:17394459\|RGD:1642698
Cellular Component	GO:0032059	bleb	P2rx7	IDA		Rat	PMID:12857854\|RGD:8554350
Cellular Component	GO:0005911	cell-cell junction	P2rx7	IDA		Mouse	PMID:15331634
Cellular Component	GO:0005737	cytoplasm	P2rx7	IDA		Rat	PMID:12857854\|RGD:8554350
Cellular Component	GO:0009897	external side of plasma membrane	P2rx7	IDA		Mouse	PMID:17286969
Cellular Component	GO:0016020	membrane	P2RX7	IDA		Human	PMID:17785580
Cellular Component	GO:0016020	membrane	P2rx7	IDA		Mouse	PMID:15713258
Cellular Component	GO:0045121	membrane raft	P2rx7	IDA		Rat	PMID:16415476\|RGD:1642712
Cellular Component	GO:0031594	neuromuscular junction	P2rx7	IPI	PR:Q9Z1M0	Mouse	PMID:15713258
Cellular Component	GO:0031594	neuromuscular junction	P2rx7	IDA		Mouse	PMID:15713258
Cellular Component	GO:0043005	neuron projection	P2rx7	IDA		Rat	PMID:16018975\|RGD:1642692
Cellular Component	GO:0043025	neuronal cell body	P2rx7	IDA		Mouse	PMID:15978588
Cellular Component	GO:0043025	neuronal cell body	P2rx7	IDA		Mouse	PMID:15964665
Cellular Component	GO:0005635	nuclear envelope	P2rx7	IDA		Rat	PMID:12422208\|RGD:628349
Cellular Component	GO:0005886	plasma membrane	P2RX7	IDA		Human	PMID:12107182
Cellular Component	GO:0005886	plasma membrane	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12677010
Cellular Component	GO:0005886	plasma membrane	P2rx7	IDA		Mouse	PMID:15331634
Cellular Component	GO:0005886	plasma membrane	P2rx7	IDA		Rat	PMID:12857854\|RGD:8554350
Cellular Component	GO:0005886	plasma membrane	P2rx7	IDA		Rat	PMID:16415476\|RGD:1642712
Cellular Component	GO:0005886	plasma membrane	P2rx7	IDA		Rat	PMID:17785580\|RGD:8554639
Cellular Component	GO:0005886	plasma membrane	p2rx7	IDA		Zfish	PMID:16837047
Cellular Component	GO:0032991	protein-containing complex	P2rx7	IDA		Rat	PMID:19416975\|RGD:5491011
Cellular Component	GO:0045202	synapse	P2rx7	IDA		Mouse	PMID:18082965
Cellular Component	GO:0043195	terminal bouton	P2rx7	IDA		Rat	PMID:16018975\|RGD:1642692
Biological Process	GO:0097190	apoptotic signaling pathway	P2rx7	IDA		Rat	PMID:12857854\|RGD:8554350
Biological Process	GO:1904669	ATP export	P2rx7	IMP		Rat	PMID:31630543\|RGD:14995937
Biological Process	GO:0032060	bleb assembly	P2RX7	IDA		Human	PMID:12107182
Biological Process	GO:0032060	bleb assembly	P2rx7	IMP		Mouse	MGI:MGI:5634870\|PMID:25651887
Biological Process	GO:0032060	bleb assembly	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:17135244
Biological Process	GO:0032060	bleb assembly	P2rx7	IDA		Rat	PMID:12857854\|RGD:8554350
Biological Process	GO:0098703	calcium ion import across plasma membrane	p2rx7	IDA		Zfish	PMID:25645917
Biological Process	GO:0006816	calcium ion transport	P2rx7	IMP	MGI:MGI:3042190	Mouse	PMID:12370338
Biological Process	GO:0000902	cell morphogenesis	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12055263
Biological Process	GO:0007166	cell surface receptor signaling pathway	P2rx7	IDA		Rat	PMID:12857854\|RGD:8554350
Biological Process	GO:0006884	cell volume homeostasis	P2rx7	IDA		Mouse	PMID:18097031
Biological Process	GO:0071359	cellular response to dsRNA	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:24114535
Biological Process	GO:0031668	cellular response to extracellular stimulus	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18082965
Biological Process	GO:0071407	cellular response to organic cyclic compound	P2rx7	IDA		Mouse	PMID:23479225
Biological Process	GO:0046513	ceramide biosynthetic process	P2rx7	IDA		Mouse	PMID:16325464
Biological Process	GO:0032963	collagen metabolic process	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16969386
Biological Process	GO:0050830	defense response to Gram-positive bacterium	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:11544318
Biological Process	GO:0051649	establishment of localization in cell	P2rx7	IMP		Mouse	PMID:16269410
Biological Process	GO:0051649	establishment of localization in cell	P2rx7	IDA		Mouse	PMID:15240711
Biological Process	GO:0051649	establishment of localization in cell	P2rx7	IMP	MGI:MGI:3042190	Mouse	PMID:12370338
Biological Process	GO:0051649	establishment of localization in cell	P2rx7	IDA		Mouse	PMID:18097031
Biological Process	GO:0051649	establishment of localization in cell	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16269410
Biological Process	GO:0051649	establishment of localization in cell	P2rx7	IMP		Mouse	PMID:17803959
Biological Process	GO:0060079	excitatory postsynaptic potential	p2rx7	IDA		Zfish	PMID:16837047\|ZFIN:ZDB-PUB-060724-2
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:17286969
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	P2rx7	IDA		Rat	PMID:12857854\|RGD:8554350
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	P2rx7	IDA		Rat	PMID:8614837\|RGD:69918
Biological Process	GO:0014051	gamma-aminobutyric acid secretion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15640761
Biological Process	GO:0010467	gene expression	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18519738
Biological Process	GO:0014047	glutamate secretion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15640761
Biological Process	GO:0014047	glutamate secretion	P2rx7	IMP		Mouse	PMID:17306762
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16969386
Biological Process	GO:0006954	inflammatory response	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16969386
Biological Process	GO:0006954	inflammatory response	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12055263
Biological Process	GO:0032610	interleukin-1 alpha production	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:18490713
Biological Process	GO:0032611	interleukin-1 beta production	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:18490713
Biological Process	GO:0032611	interleukin-1 beta production	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:11016935
Biological Process	GO:0032611	interleukin-1 beta production	P2rx7	IMP		Mouse	PMID:15905573
Biological Process	GO:0032635	interleukin-6 production	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:11016935
Biological Process	GO:0070227	lymphocyte apoptotic process	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16493071
Biological Process	GO:0048246	macrophage chemotaxis	p2rx7	IMP	ZFIN:ZDB-MRPHLNO-121203-8	Zfish	PMID:24203886
Biological Process	GO:0010934	macrophage cytokine production	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:11016935
Biological Process	GO:0010934	macrophage cytokine production	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:18490713
Biological Process	GO:0000165	MAPK cascade	P2rx7	IMP		Mouse	PMID:15937334
Biological Process	GO:0051899	membrane depolarization	P2RX7	IDA		Human	PMID:9038151
Biological Process	GO:0051899	membrane depolarization	P2rx7	IDA		Rat	PMID:8614837\|RGD:69918
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:17286969
Biological Process	GO:0051882	mitochondrial depolarization	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16198349
Biological Process	GO:0007005	mitochondrion organization	P2rx7	IDA		Mouse	PMID:16325464
Biological Process	GO:0098655	monoatomic cation transmembrane transport	p2rx7	IDA		Zfish	PMID:16837047\|ZFIN:ZDB-PUB-060724-2
Biological Process	GO:0006812	monoatomic cation transport	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12677010
Biological Process	GO:0006812	monoatomic cation transport	p2rx7	IDA		Zfish	PMID:14580944
Biological Process	GO:0006812	monoatomic cation transport	p2rx7	IDA		Zfish	PMID:16837047
Biological Process	GO:0043132	NAD transport	P2rx7	IMP		Mouse	PMID:17803959
Biological Process	GO:0045779	negative regulation of bone resorption	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12677010
Biological Process	GO:0045794	negative regulation of cell volume	P2RX7	IMP		Human	PMID:25651887
Biological Process	GO:0045794	negative regulation of cell volume	P2rx7	IMP		Mouse	MGI:MGI:5634870\|PMID:25651887
Biological Process	GO:0043409	negative regulation of MAPK cascade	P2rx7	IDA		Mouse	PMID:11489964
Biological Process	GO:0019228	neuronal action potential	P2rx7	IDA		Rat	PMID:17394459\|RGD:1642698
Biological Process	GO:0001845	phagolysosome assembly	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:11544318
Biological Process	GO:0006649	phospholipid transfer to membrane	P2rx7	IMP	MGI:MGI:3042190	Mouse	PMID:12370338
Biological Process	GO:0045332	phospholipid translocation	P2rx7	IDA		Mouse	PMID:18097031
Biological Process	GO:0007009	plasma membrane organization	P2rx7	IDA		Mouse	PMID:18097031
Biological Process	GO:0017121	plasma membrane phospholipid scrambling	P2RX7	IDA		Human	PMID:25651887
Biological Process	GO:0046931	pore complex assembly	P2RX7	IMP		Human	PMID:25651887
Biological Process	GO:0046931	pore complex assembly	P2RX7	IDA		Human	PMID:9038151
Biological Process	GO:0046931	pore complex assembly	P2rx7	IMP	MGI:MGI:3042190	Mouse	PMID:12370338
Biological Process	GO:0046931	pore complex assembly	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16269410
Biological Process	GO:0046931	pore complex assembly	P2rx7	IMP		Mouse	PMID:15937334
Biological Process	GO:0046931	pore complex assembly	P2rx7	IDA		Rat	PMID:15883745\|RGD:1642715
Biological Process	GO:0046931	pore complex assembly	P2rx7	IMP		Rat	PMID:15883745\|RGD:1642715
Biological Process	GO:0043065	positive regulation of apoptotic process	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16969386
Biological Process	GO:1904172	positive regulation of bleb assembly	P2RX7	IMP		Human	PMID:25651887
Biological Process	GO:0030501	positive regulation of bone mineralization	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18519738
Biological Process	GO:0030501	positive regulation of bone mineralization	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12677010
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	P2RX7	IDA		Human	PMID:9038151
Biological Process	GO:0043085	positive regulation of catalytic activity	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:14761980
Biological Process	GO:0051495	positive regulation of cytoskeleton organization	P2rx7	IDA		Rat	PMID:12857854\|RGD:8554350
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15640761
Biological Process	GO:0010628	positive regulation of gene expression	P2RX7	IMP		Human	PMID:22898868
Biological Process	GO:0014049	positive regulation of glutamate secretion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15640761
Biological Process	GO:0014049	positive regulation of glutamate secretion	P2rx7	IMP		Mouse	PMID:17306762
Biological Process	GO:0045821	positive regulation of glycolytic process	P2RX7	IMP		Human	PMID:22898868
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:18490713
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	P2RX7	IDA		Human	PMID:17036048
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	P2RX7	IDA		Human	PMID:18089587
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	P2rx7	IMP		Mouse	PMID:15905573
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:18490713
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:11016935
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	P2rx7	IDA		Rat	PMID:15883745\|RGD:1642715
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	P2rx7	IMP		Rat	PMID:15883745\|RGD:1642715
Biological Process	GO:0032755	positive regulation of interleukin-6 production	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:11016935
Biological Process	GO:0070230	positive regulation of lymphocyte apoptotic process	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16493071
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:18490713
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:11016935
Biological Process	GO:0043406	positive regulation of MAP kinase activity	P2rx7	IMP		Mouse	PMID:17306762
Biological Process	GO:0043410	positive regulation of MAPK cascade	P2rx7	IMP		Mouse	PMID:15937334
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16198349
Biological Process	GO:0034767	positive regulation of monoatomic ion transmembrane transport	P2RX7	IMP		Human	PMID:25651887
Biological Process	GO:0045778	positive regulation of ossification	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16269410
Biological Process	GO:0045778	positive regulation of ossification	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18519738
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16269410
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	P2rx7	IMP		Mouse	PMID:16269410
Biological Process	GO:0001934	positive regulation of protein phosphorylation	P2rx7	IMP		Mouse	PMID:17448897
Biological Process	GO:0001934	positive regulation of protein phosphorylation	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15937334
Biological Process	GO:0001934	positive regulation of protein phosphorylation	P2rx7	IDA		Rat	PMID:15023862\|RGD:1642719
Biological Process	GO:0050714	positive regulation of protein secretion	P2rx7	IDA		Mouse	PMID:15240711
Biological Process	GO:0070234	positive regulation of T cell apoptotic process	P2rx7	IMP		Mouse	PMID:16325464
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	P2rx7	IMP	MGI:MGI:3042190	Mouse	PMID:14761980
Biological Process	GO:0012501	programmed cell death	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:14761980
Biological Process	GO:0012501	programmed cell death	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16116196
Biological Process	GO:0012501	programmed cell death	P2rx7	IDA		Mouse	PMID:16116196
Biological Process	GO:0012501	programmed cell death	P2rx7	IDA		Mouse	PMID:18097031
Biological Process	GO:0012501	programmed cell death	P2rx7	IMP	MGI:MGI:3042190	Mouse	PMID:14761980
Biological Process	GO:0032310	prostaglandin secretion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16269410
Biological Process	GO:0032310	prostaglandin secretion	P2rx7	IMP		Mouse	PMID:16269410
Biological Process	GO:0030163	protein catabolic process	P2rx7	IDA		Mouse	PMID:11489964
Biological Process	GO:0006468	protein phosphorylation	P2rx7	IMP		Mouse	PMID:17306762
Biological Process	GO:0016485	protein processing	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:11016935
Biological Process	GO:0009306	protein secretion	P2rx7	IDA		Mouse	PMID:15240711
Biological Process	GO:0035590	purinergic nucleotide receptor signaling pathway	P2RX7	IMP		Human	PMID:25651887
Biological Process	GO:0072593	reactive oxygen species metabolic process	P2rx7	IMP		Mouse	PMID:17448897
Biological Process	GO:0099161	regulation of presynaptic dense core granule exocytosis	P2rx7	EXP		Rat	PMID:24037803\|RGD:13702177
Biological Process	GO:0099161	regulation of presynaptic dense core granule exocytosis	P2rx7	IDA		Rat	PMID:24037803\|RGD:13702177
Biological Process	GO:0002028	regulation of sodium ion transport	P2rx7	IDA		Rat	PMID:17785580\|RGD:8554639
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18082965
Biological Process	GO:0033198	response to ATP	P2RX7	IDA		Human	PMID:9038151
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15978588
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:11016935
Biological Process	GO:0033198	response to ATP	P2rx7	IDA		Mouse	PMID:15240711
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18082965
Biological Process	GO:0033198	response to ATP	P2rx7	IDA		Mouse	PMID:15713258
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15937334
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12055263
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:17286969
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:18490713
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:3606250	Mouse	PMID:11544318
Biological Process	GO:0033198	response to ATP	P2rx7	IMP		Mouse	PMID:17448897
Biological Process	GO:0033198	response to ATP	P2rx7	IMP		Mouse	PMID:16325464
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18097031
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:14761980
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18519738
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16198349
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:17135244
Biological Process	GO:0033198	response to ATP	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16116196
Biological Process	GO:0033198	response to ATP	P2rx7	IDA		Rat	PMID:8614837\|RGD:69918
Biological Process	GO:0009617	response to bacterium	P2rx7	IMP		Mouse	PMID:10395640
Biological Process	GO:0051592	response to calcium ion	P2rx7	IDA		Mouse	PMID:15240711
Biological Process	GO:0051592	response to calcium ion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18082965
Biological Process	GO:0051592	response to calcium ion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15978588
Biological Process	GO:0051602	response to electrical stimulus	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15640761
Biological Process	GO:0034405	response to fluid shear stress	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16269410
Biological Process	GO:0032496	response to lipopolysaccharide	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:12055263
Biological Process	GO:0032496	response to lipopolysaccharide	P2rx7	IMP		Mouse	PMID:17448897
Biological Process	GO:0032496	response to lipopolysaccharide	P2rx7	IDA		Mouse	PMID:15240711
Biological Process	GO:0009612	response to mechanical stimulus	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16269410
Biological Process	GO:0014070	response to organic cyclic compound	P2rx7	IDA		Mouse	PMID:15240711
Biological Process	GO:0010033	response to organic substance	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16455971
Biological Process	GO:0010033	response to organic substance	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:17286969
Biological Process	GO:0010033	response to organic substance	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16116196
Biological Process	GO:0009410	response to xenobiotic stimulus	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18082965
Biological Process	GO:0010043	response to zinc ion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18082965
Biological Process	GO:0010043	response to zinc ion	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15978588
Biological Process	GO:0019233	sensory perception of pain	P2rx7	IMP		Mouse	MGI:MGI:3605949\|PMID:15777864
Biological Process	GO:0048705	skeletal system morphogenesis	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:18519738
Biological Process	GO:0016079	synaptic vesicle exocytosis	P2rx7	IMP		Mouse	PMID:15713258
Biological Process	GO:0070231	T cell apoptotic process	P2rx7	IMP		Mouse	PMID:16325464
Biological Process	GO:0043029	T cell homeostasis	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:16116196
Biological Process	GO:0001913	T cell mediated cytotoxicity	P2rx7	IMP	MGI:MGI:3042190	Mouse	PMID:14761980
Biological Process	GO:0042098	T cell proliferation	P2rx7	IMP	MGI:MGI:2386080	Mouse	PMID:15914561
Biological Process	GO:0006900	vesicle budding from membrane	P2rx7	IMP		Mouse	PMID:15905573

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.