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P2rx7
Gene Detail
Symbol

Name
ID
P2rx7
purinergic receptor P2X, ligand-gated ion channel, 7
MGI:1339957
Synonyms
P2X(7), P2X7R, P2X7 receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.50 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:122643911-122691432 bp, + strand
From VEGA annotation of GRCm38

  47522 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1925  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Gene Tree: P2rx7

Human
homologs
Human Homolog P2RX7, purinergic receptor P2X, ligand-gated ion channel, 7
NCBI Gene ID 5027
neXtProt AC  NX_Q99572
Human Synonyms  P2X7
Human Chr (Location)  12q24; chr12:121132819-121186551 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Spontaneous(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are fertile and viable with no obvious phenotypic abnormality. Cellular responses of macrophages to extracellular ATP are frequently normal however. In addition, long bones are thinner than normal in adult mice.
 
Interactions
P2rx7 interacts with 311 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (123 annotations)
Process activation of MAPK activity, bleb assembly, ...
Component cell-cell junction, cytosol, ...
Function ATP binding, channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (7)    Tissues (5)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 7
cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000026740 (Evidence)
Ensembl Gene ModelENSMUSG00000029468 (Evidence)
Entrez Gene18439 (Evidence)
UniGene42026
DFCITC1585870, TC1588530, TC1589640, TC1625377
DoTSDT.101355105, DT.91336254, DT.94273607, DT.94391133, DT.99849462
NIA Mouse Gene IndexU042686
Consensus CDS ProjectCCDS19651.1, CCDS19652.1, CCDS19653.1, CCDS51644.1
International Mouse Knockout Project StatusP2rx7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026740 VEGA Gene Model | MGI Sequence Detail 47522 C57BL/6J ±  kb
transcript OTTMUST00000066137 VEGA | MGI Sequence Detail 4936 Not Applicable 
polypeptide OTTMUSP00000033090 VEGA | MGI Sequence Detail 595 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(10) UniProt(11)
Polymorphisms
SNPs within 2kb(462 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003050 P2X7 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012194 P2X purinoceptor 7
References
(Earliest) J:51040 Chessell IP, et al., Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett. 1998 Nov 13;439(1-2):26-30
(Latest) J:212558 da Silva-Souza HA, et al., Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages. Biochim Biophys Acta. 2014 Jul;1838(7):1967-77
All references(220)
Other
accession IDs
MGI:2140909

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory