P2rx7
Gene Detail

Symbol Name ID

P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 MGI:1339957

Synonyms

P2X(7), P2X7R, P2X7 receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 5

62.50 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:122643911-122691432 bp, + strand From VEGA annotation of GRCm38   47522 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human P2rx7 ± 2 cM)

Gene Tree: P2rx7

Human ortholog

P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7 NCBI Gene ID 5027
Human Synonyms: P2X7
Human Chr12:121570622-121624354 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(1) Spontaneous(1)
 

Mice homozygous for disruptions in this gene are fertile and viable with no obvious phenotypic abnormality. Cellular responses of macrophages to extracellular ATP are frequently normal however. In addition, long bones are thinner than normal in adult mice.

 

Gene Ontology (GO) classifications

All GO classifications: (149 annotations)

Process	activation of MAPK activity, bleb assembly, ...
Component	bleb, cell-cell junction, ...
Function	ATP binding, channel activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (7)    Tissues (4)    Images (2)
Theiler Stages: 22, 25, 28

Assay Type	Results
RT-PCR	7

cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(30) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000026740 (Evidence)
Ensembl Gene Model	ENSMUSG00000029468 (Evidence)
Entrez Gene	18439 (Evidence)
UniGene	42026
DFCI	TC1585870, TC1588530, TC1589640, TC1625377
DoTS	DT.101355105, DT.91336254, DT.94273607, DT.94391133, DT.99849462
NIA Mouse Gene Index	U042686
Consensus CDS Project	CCDS19651.1, CCDS19652.1, CCDS19653.1, CCDS51644.1
International Mouse Knockout Project Status	P2rx7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026740	VEGA Gene Model | MGI Sequence Detail	47522	C57BL/6J
transcript	OTTMUST00000066137	VEGA | MGI Sequence Detail	4936	Not Applicable
polypeptide	OTTMUSP00000033090	VEGA | MGI Sequence Detail	595	Not Applicable

All sequences(68) RefSeq(8) UniProt(11)

Polymorphisms

SNPs(330 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003050	P2X7 purinoceptor
InterPro	IPR001429	P2X purinoreceptor
Protein Ontology	PR:000012194	P2X purinoceptor 7

References

(Earliest) J:51040 Chessell IP, et al., Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett. 1998 Nov 13;439(1-2):26-30
(Latest) J:193771 Deplano S, et al., P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis. J Leukoc Biol. 2013 Jan;93(1):127-34
All references(192)

Other accession IDs

MGI:2140909