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Term Detail
GO term:T cell mediated cytotoxicity
Synonym: T cell mediated apoptosis
Synonym: T-cell mediated apoptosis
Synonym: T cell mediated cell death
Synonym: T-cell mediated cell death
Synonym: T cell mediated cell killing
Synonym: T-cell mediated cell killing
Synonym: T cell mediated cytolysis
Synonym: T-cell mediated cytotoxicity
Synonym: T lymphocyte mediated cytotoxicity
Synonym: T-lymphocyte mediated cytotoxicity
GO id:GO:0001913
Definition:The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
CommentsNote that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
Number of paths to term: 6

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acell killing
                        is-aleukocyte mediated cytotoxicity
                                is-aantibody-dependent cellular cytotoxicity +
                                is-anatural killer cell mediated cytotoxicity +
                                negatively-regulatesnegative regulation of leukocyte mediated cytotoxicity +
                                is-aneutrophil mediated cytotoxicity +
                                positively-regulatespositive regulation of leukocyte mediated cytotoxicity +
                                regulatesregulation of leukocyte mediated cytotoxicity +
                                is-aT cell mediated cytotoxicity [GO:0001913] (40 genes, 45 annotations)
                                        part-ofcytotoxic T cell degranulation +
                                        negatively-regulatesnegative regulation of T cell mediated cytotoxicity +
                                        positively-regulatespositive regulation of T cell mediated cytotoxicity +
                                        regulatesregulation of T cell mediated cytotoxicity +
                                        is-aT cell mediated cytotoxicity directed against tumor cell target +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune effector process
                                is-aleukocyte mediated immunity
                                        is-aleukocyte mediated cytotoxicity
                                                is-aantibody-dependent cellular cytotoxicity +
                                                is-anatural killer cell mediated cytotoxicity +
                                                negatively-regulatesnegative regulation of leukocyte mediated cytotoxicity +
                                                is-aneutrophil mediated cytotoxicity +
                                                positively-regulatespositive regulation of leukocyte mediated cytotoxicity +
                                                regulatesregulation of leukocyte mediated cytotoxicity +
                                                is-aT cell mediated cytotoxicity [GO:0001913] (40 genes, 45 annotations)
                                                        part-ofcytotoxic T cell degranulation +
                                                        negatively-regulatesnegative regulation of T cell mediated cytotoxicity +
                                                        positively-regulatespositive regulation of T cell mediated cytotoxicity +
                                                        regulatesregulation of T cell mediated cytotoxicity +
                                                        is-aT cell mediated cytotoxicity directed against tumor cell target +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune effector process
                                is-aleukocyte mediated immunity
                                        is-alymphocyte mediated immunity
                                                is-aT cell mediated immunity
                                                        negatively-regulatesnegative regulation of T cell mediated immunity +
                                                        is-aperipheral T cell tolerance induction +
                                                        positively-regulatespositive regulation of T cell mediated immunity +
                                                        regulatesregulation of T cell mediated immunity +
                                                        part-ofT cell antigen processing and presentation +
                                                        is-aT cell cytokine production +
                                                        is-aT cell mediated cytotoxicity [GO:0001913] (40 genes, 45 annotations)
                                                                part-ofcytotoxic T cell degranulation +
                                                                negatively-regulatesnegative regulation of T cell mediated cytotoxicity +
                                                                positively-regulatespositive regulation of T cell mediated cytotoxicity +
                                                                regulatesregulation of T cell mediated cytotoxicity +
                                                                is-aT cell mediated cytotoxicity directed against tumor cell target +
                                                        is-aT cell mediated immune response to tumor cell +
                                                        is-atype IV hypersensitivity +


Gene_Ontology
        is-abiological_process
                is-aimmune system process
                        is-aimmune response
                                is-aadaptive immune response
                                        is-aadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
                                                is-aT cell mediated immunity
                                                        negatively-regulatesnegative regulation of T cell mediated immunity +
                                                        is-aperipheral T cell tolerance induction +
                                                        positively-regulatespositive regulation of T cell mediated immunity +
                                                        regulatesregulation of T cell mediated immunity +
                                                        part-ofT cell antigen processing and presentation +
                                                        is-aT cell cytokine production +
                                                        is-aT cell mediated cytotoxicity [GO:0001913] (40 genes, 45 annotations)
                                                                part-ofcytotoxic T cell degranulation +
                                                                negatively-regulatesnegative regulation of T cell mediated cytotoxicity +
                                                                positively-regulatespositive regulation of T cell mediated cytotoxicity +
                                                                regulatesregulation of T cell mediated cytotoxicity +
                                                                is-aT cell mediated cytotoxicity directed against tumor cell target +
                                                        is-aT cell mediated immune response to tumor cell +
                                                        is-atype IV hypersensitivity +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aimmune response
                                is-aadaptive immune response
                                        is-aadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
                                                is-aT cell mediated immunity
                                                        negatively-regulatesnegative regulation of T cell mediated immunity +
                                                        is-aperipheral T cell tolerance induction +
                                                        positively-regulatespositive regulation of T cell mediated immunity +
                                                        regulatesregulation of T cell mediated immunity +
                                                        part-ofT cell antigen processing and presentation +
                                                        is-aT cell cytokine production +
                                                        is-aT cell mediated cytotoxicity [GO:0001913] (40 genes, 45 annotations)
                                                                part-ofcytotoxic T cell degranulation +
                                                                negatively-regulatesnegative regulation of T cell mediated cytotoxicity +
                                                                positively-regulatespositive regulation of T cell mediated cytotoxicity +
                                                                regulatesregulation of T cell mediated cytotoxicity +
                                                                is-aT cell mediated cytotoxicity directed against tumor cell target +
                                                        is-aT cell mediated immune response to tumor cell +
                                                        is-atype IV hypersensitivity +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-aantibody-dependent cellular cytotoxicity +
                        is-acarbohydrate utilization +
                        is-acarbon utilization +
                        is-acell proliferation +
                        is-acomplement-dependent cytotoxicity
                        is-adeath +
                        is-aestablishment of pole plasm mRNA localization
                        is-aestablishment of protein localization to extracellular region +
                        is-afilamentous growth +
                        is-alateral growth +
                        is-anatural killer cell mediated cytotoxicity +
                        is-anitrogen utilization +
                        is-aovulation cycle process +
                        is-aphosphorus utilization +
                        is-apigmentation +
                        is-asingle organism cell adhesion +
                        is-asingle organism reproductive process +
                        is-asingle organism signaling +
                        is-asingle-multicellular organism process +
                        is-asingle-organism behavior +
                        is-asingle-organism cellular process +
                        is-asingle-organism developmental process +
                        is-asingle-organism localization +
                        is-asingle-organism membrane organization +
                        is-asingle-organism metabolic process +
                        is-asingle-organism transport +
                        is-asulfur utilization +
                        is-aT cell mediated cytotoxicity [GO:0001913] (40 genes, 45 annotations)
                                part-ofcytotoxic T cell degranulation +
                                negatively-regulatesnegative regulation of T cell mediated cytotoxicity +
                                positively-regulatespositive regulation of T cell mediated cytotoxicity +
                                regulatesregulation of T cell mediated cytotoxicity +
                                is-aT cell mediated cytotoxicity directed against tumor cell target +
                        is-aultradian rhythm +


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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory