| GO term: | T cell mediated cytotoxicity |
| Synonym: | T cell mediated apoptosis |
| Synonym: | T-cell mediated apoptosis |
| Synonym: | T cell mediated cell death |
| Synonym: | T-cell mediated cell death |
| Synonym: | T cell mediated cell killing |
| Synonym: | T-cell mediated cell killing |
| Synonym: | T cell mediated cytolysis |
| Synonym: | T-cell mediated cytotoxicity |
| Synonym: | T lymphocyte mediated cytotoxicity |
| Synonym: | T-lymphocyte mediated cytotoxicity |
| GO id: | GO:0001913 |
| Definition: | The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. |
| Comments | Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. |
| Number of paths to term: | 6 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcell killingleukocyte mediated cytotoxicityantibody-dependent cellular cytotoxicity +natural killer cell mediated cytotoxicity +negative regulation of leukocyte mediated cytotoxicity +neutrophil mediated cytotoxicity +positive regulation of leukocyte mediated cytotoxicity +regulation of leukocyte mediated cytotoxicity +T cell mediated cytotoxicity [GO:0001913] (29 genes, 34 annotations)cytotoxic T cell degranulation +negative regulation of T cell mediated cytotoxicity +positive regulation of T cell mediated cytotoxicity +regulation of T cell mediated cytotoxicity +T cell mediated cytotoxicity directed against tumor cell target +biological_processimmune system processimmune effector processleukocyte mediated immunityleukocyte mediated cytotoxicityantibody-dependent cellular cytotoxicity +natural killer cell mediated cytotoxicity +negative regulation of leukocyte mediated cytotoxicity +neutrophil mediated cytotoxicity +positive regulation of leukocyte mediated cytotoxicity +regulation of leukocyte mediated cytotoxicity +T cell mediated cytotoxicity [GO:0001913] (29 genes, 34 annotations)cytotoxic T cell degranulation +negative regulation of T cell mediated cytotoxicity +positive regulation of T cell mediated cytotoxicity +regulation of T cell mediated cytotoxicity +T cell mediated cytotoxicity directed against tumor cell target +biological_processimmune system processimmune effector processleukocyte mediated immunitylymphocyte mediated immunityT cell mediated immunitynegative regulation of T cell mediated immunity +peripheral T cell tolerance induction +positive regulation of T cell mediated immunity +regulation of T cell mediated immunity +T cell antigen processing and presentation +T cell cytokine production +T cell mediated cytotoxicity [GO:0001913] (29 genes, 34 annotations)cytotoxic T cell degranulation +negative regulation of T cell mediated cytotoxicity +positive regulation of T cell mediated cytotoxicity +regulation of T cell mediated cytotoxicity +T cell mediated cytotoxicity directed against tumor cell target +T cell mediated immune response to tumor cell +type IV hypersensitivity +biological_processimmune system processimmune responseadaptive immune responseadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsT cell mediated immunitynegative regulation of T cell mediated immunity +peripheral T cell tolerance induction +positive regulation of T cell mediated immunity +regulation of T cell mediated immunity +T cell antigen processing and presentation +T cell cytokine production +T cell mediated cytotoxicity [GO:0001913] (29 genes, 34 annotations)cytotoxic T cell degranulation +negative regulation of T cell mediated cytotoxicity +positive regulation of T cell mediated cytotoxicity +regulation of T cell mediated cytotoxicity +T cell mediated cytotoxicity directed against tumor cell target +T cell mediated immune response to tumor cell +type IV hypersensitivity +biological_processresponse to stimulusimmune responseadaptive immune responseadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsT cell mediated immunitynegative regulation of T cell mediated immunity +peripheral T cell tolerance induction +positive regulation of T cell mediated immunity +regulation of T cell mediated immunity +T cell antigen processing and presentation +T cell cytokine production +T cell mediated cytotoxicity [GO:0001913] (29 genes, 34 annotations)cytotoxic T cell degranulation +negative regulation of T cell mediated cytotoxicity +positive regulation of T cell mediated cytotoxicity +regulation of T cell mediated cytotoxicity +T cell mediated cytotoxicity directed against tumor cell target +T cell mediated immune response to tumor cell +type IV hypersensitivity +biological_processsingle-organism processantibody-dependent cellular cytotoxicity +carbohydrate utilization +carbon utilization +cell proliferation +complement-dependent cytotoxicitydeath +eclosion rhythmestablishment of pole plasm mRNA localizationestablishment of protein localization to extracellular region +filamentous growth +lateral growth +locomotor rhythmnatural killer cell mediated cytotoxicity +nitrogen utilization +ovulation cycle process +phosphorus utilization +pigmentation +protein activation cascade +single organism reproductive process +single organism signaling +single-multicellular organism process +single-organism cellular process +single-organism developmental process +single-organism transport +sulfur utilization +T cell mediated cytotoxicity [GO:0001913] (29 genes, 34 annotations)cytotoxic T cell degranulation +negative regulation of T cell mediated cytotoxicity +positive regulation of T cell mediated cytotoxicity +regulation of T cell mediated cytotoxicity +T cell mediated cytotoxicity directed against tumor cell target +ultradian rhythm +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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