| GO term: | MAPK cascade |
| Synonym: | ERK/MAPK cascade |
| Synonym: | MAP kinase cascade |
| Synonym: | MAP kinase kinase kinase cascade |
| Synonym: | MAPKKK cascade |
| Synonym: | MAPKKK cascade during sporulation |
| Synonym: | MAPK signaling |
| Synonym: | MAPK signalling |
| Synonym: | mitogen-activated protein kinase cascade |
| GO id: | GO:0000165 |
| Definition: | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| Comments | MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. |
| Number of paths to term: | 10 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeI-kappaB kinase/NF-kappaB cascade +JAK-STAT cascade +MAPK cascade [GO:0000165] (501 genes, 882 annotations)ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +negative regulation of intracellular protein kinase cascade +positive regulation of intracellular protein kinase cascade +protein kinase A signaling cascade +protein kinase B signaling cascade +protein kinase C signaling cascade +regulation of intracellular protein kinase cascade +septation initiation signaling cascade +stress-activated protein kinase signaling cascade +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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