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Term Detail
GO term:MAPK cascade
Synonym: ERK/MAPK cascade
Synonym: MAP kinase cascade
Synonym: MAP kinase kinase kinase cascade
Synonym: MAPKKK cascade
Synonym: MAPKKK cascade during sporulation
Synonym: MAPK signaling
Synonym: MAPK signalling
Synonym: MAPK signal transduction
Synonym: mitogen-activated protein kinase cascade
GO id:GO:0000165
Definition:An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
CommentsMAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
Number of paths to term: 24

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                                is-aERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                                is-aERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +
                                                        is-asignal transduction by cis-phosphorylation
                                                        is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aphosphorus metabolic process
                                        is-aphosphate-containing compound metabolic process
                                                is-aphosphorylation
                                                        is-asignal transduction by phosphorylation
                                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                                        is-aERK1 and ERK2 cascade +
                                                                        is-aERK5 cascade +
                                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                        is-aMAPK cascade involved in innate immune response +
                                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                        part-ofMAPK import into nucleus +
                                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                                        positively-regulatespositive regulation of MAPK cascade +
                                                                        regulatesregulation of MAPK cascade +
                                                                        is-astress-activated MAPK cascade +
                                                                is-asignal transduction by cis-phosphorylation
                                                                is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-asignal transduction by cis-phosphorylation
                                                is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-asignal transduction by cis-phosphorylation
                                                is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                                is-aERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                                is-aERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +
                                                        is-asignal transduction by cis-phosphorylation
                                                        is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                is-aERK1 and ERK2 cascade +
                                                is-aERK5 cascade +
                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                is-aMAPK cascade involved in innate immune response +
                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                part-ofMAPK import into nucleus +
                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                positively-regulatespositive regulation of MAPK cascade +
                                                regulatesregulation of MAPK cascade +
                                                is-astress-activated MAPK cascade +
                                        is-asignal transduction by cis-phosphorylation
                                        is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aphosphorus metabolic process
                                        is-aphosphate-containing compound metabolic process
                                                is-aphosphorylation
                                                        is-asignal transduction by phosphorylation
                                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                                        is-aERK1 and ERK2 cascade +
                                                                        is-aERK5 cascade +
                                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                        is-aMAPK cascade involved in innate immune response +
                                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                        part-ofMAPK import into nucleus +
                                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                                        positively-regulatespositive regulation of MAPK cascade +
                                                                        regulatesregulation of MAPK cascade +
                                                                        is-astress-activated MAPK cascade +
                                                                is-asignal transduction by cis-phosphorylation
                                                                is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                is-aERK1 and ERK2 cascade +
                                                is-aERK5 cascade +
                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                is-aMAPK cascade involved in innate immune response +
                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                part-ofMAPK import into nucleus +
                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                positively-regulatespositive regulation of MAPK cascade +
                                                regulatesregulation of MAPK cascade +
                                                is-astress-activated MAPK cascade +
                                        is-asignal transduction by cis-phosphorylation
                                        is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-asignal transduction by cis-phosphorylation
                                                is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-asignal transduction by cis-phosphorylation
                                                is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-asignal transduction by cis-phosphorylation
                                                is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-acytoplasmic pattern recognition receptor signaling pathway +
                                                is-aendosomal signal transduction
                                                is-ahippo signaling +
                                                is-aI-kappaB kinase/NF-kappaB signaling +
                                                is-ainositol lipid-mediated signaling +
                                                is-aintrinsic apoptotic signaling pathway +
                                                is-aJAK-STAT cascade +
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-aMAPK import into nucleus involved in innate immune response
                                                negatively-regulatesnegative regulation of intracellular signal transduction +
                                                is-aNIK/NF-kappaB signaling +
                                                is-aPKR signal transduction
                                                positively-regulatespositive regulation of intracellular signal transduction +
                                                is-aprotein kinase A signaling +
                                                is-aprotein kinase B signaling +
                                                is-aprotein kinase C signaling +
                                                regulatesregulation of intracellular signal transduction +
                                                is-asecond-messenger-mediated signaling +
                                                is-asignal transduction by p53 class mediator +
                                                is-asignal transduction downstream of smoothened +
                                                is-asignal transduction in response to DNA damage +
                                                is-asignal transduction involved in cell cycle checkpoint +
                                                is-asmall GTPase mediated signal transduction +
                                                is-astress-activated protein kinase signaling cascade +
                                                is-aTOR signaling +
                                                is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                        is-aERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +
                                                is-asignal transduction by cis-phosphorylation
                                                is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-acytoplasmic pattern recognition receptor signaling pathway +
                                                        is-aendosomal signal transduction
                                                        is-ahippo signaling +
                                                        is-aI-kappaB kinase/NF-kappaB signaling +
                                                        is-ainositol lipid-mediated signaling +
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        is-aJAK-STAT cascade +
                                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                                is-aERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +
                                                        is-aMAPK import into nucleus involved in innate immune response
                                                        negatively-regulatesnegative regulation of intracellular signal transduction +
                                                        is-aNIK/NF-kappaB signaling +
                                                        is-aPKR signal transduction
                                                        positively-regulatespositive regulation of intracellular signal transduction +
                                                        is-aprotein kinase A signaling +
                                                        is-aprotein kinase B signaling +
                                                        is-aprotein kinase C signaling +
                                                        regulatesregulation of intracellular signal transduction +
                                                        is-asecond-messenger-mediated signaling +
                                                        is-asignal transduction by p53 class mediator +
                                                        is-asignal transduction downstream of smoothened +
                                                        is-asignal transduction in response to DNA damage +
                                                        is-asignal transduction involved in cell cycle checkpoint +
                                                        is-asmall GTPase mediated signal transduction +
                                                        is-astress-activated protein kinase signaling cascade +
                                                        is-aTOR signaling +
                                                        is-aTRAF-mediated signal transduction


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                                is-aERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +
                                                        is-asignal transduction by cis-phosphorylation
                                                        is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                is-aERK1 and ERK2 cascade +
                                                is-aERK5 cascade +
                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                is-aMAPK cascade involved in innate immune response +
                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                part-ofMAPK import into nucleus +
                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                positively-regulatespositive regulation of MAPK cascade +
                                                regulatesregulation of MAPK cascade +
                                                is-astress-activated MAPK cascade +
                                        is-asignal transduction by cis-phosphorylation
                                        is-asignal transduction by trans-phosphorylation


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade [GO:0000165] (544 genes, 997 annotations)
                                                is-aERK1 and ERK2 cascade +
                                                is-aERK5 cascade +
                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                is-aMAPK cascade involved in innate immune response +
                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                part-ofMAPK import into nucleus +
                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                positively-regulatespositive regulation of MAPK cascade +
                                                regulatesregulation of MAPK cascade +
                                                is-astress-activated MAPK cascade +
                                        is-asignal transduction by cis-phosphorylation
                                        is-asignal transduction by trans-phosphorylation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory