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Gene Ontology Browser
Term Detail
GO term:inflammatory response
Synonym: Inflammation
GO id:GO:0006954
Definition:The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
CommentsThis term was improved by GO_REF:0000022. It was moved.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-adefense response
                                        is-abehavioral defense response +
                                        is-acellular defense response +
                                        is-aclearance of foreign intracellular DNA +
                                        is-adefense response by callose deposition +
                                        part-ofdefense response by callose deposition in cell wall
                                        is-adefense response by cell wall thickening +
                                        is-adefense response to other organism +
                                        is-adefense response to tumor cell
                                        is-ainflammatory response [GO:0006954] (517 genes, 727 annotations)
                                                is-aacute inflammatory response +
                                                is-achronic inflammatory response +
                                                part-ofcytokine production involved in inflammatory response +
                                                part-ofhistamine secretion involved in inflammatory response +
                                                is-ainflammatory response to antigenic stimulus +
                                                is-ainflammatory response to wounding +
                                                part-ofleukocyte activation involved in inflammatory response
                                                part-ofleukocyte chemotaxis involved in inflammatory response
                                                part-ofleukocyte migration involved in inflammatory response +
                                                part-oflysosomal enzyme secretion involved in inflammatory response
                                                negatively-regulatesnegative regulation of inflammatory response +
                                                part-ofplatelet activating factor production involved in inflammatory response +
                                                part-ofplatelet activating factor secretion involved in inflammatory response
                                                positively-regulatespositive regulation of inflammatory response +
                                                part-ofproduction of molecular mediator involved in inflammatory response +
                                                regulatesregulation of inflammatory response +
                                                regulatesregulation of inflammatory response by sphingosine-1-phosphate signaling pathway
                                                part-ofrespiratory burst involved in inflammatory response +
                                                part-ofserotonin secretion involved in inflammatory response +
                                                part-ofwound healing involved in inflammatory response +
                                        is-ainnate immune response +
                                        negatively-regulatesnegative regulation of defense response +
                                        positively-regulatespositive regulation of defense response +
                                        regulatesregulation of defense response +
                                        part-ofrespiratory burst involved in defense response +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory