| GO term: | extrinsic apoptotic signaling pathway |
| Synonym: | death receptor-mediated apoptosis |
| Synonym: | extrinsic apoptosis |
| Synonym: | extrinsic apoptotic pathway |
| Synonym: | extrinsic apoptotic signaling pathway in presence of ligand |
| Synonym: | extrinsic apoptotic signalling pathway |
| GO id: | GO:0097191 |
| Definition: | A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
| Comments | Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer. |
| Number of paths to term: | 23 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processcellular processregulation of cellular processsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processresponse to stimuluscellular response to stimulussignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processresponse to stimuluscellular response to stimulussignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processsignalingsingle organism signalingsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsignalingsingle organism signalingsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle organism signalingsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle organism signalingsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayapoptosome assemblyextrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwaygranzyme-mediated apoptotic signaling pathwayhormone-mediated apoptotic signaling pathwayintrinsic apoptotic signaling pathway +mitochondrial outer membrane permeabilization +negative regulation of apoptotic signaling pathway +positive regulation of apoptotic signaling pathway +protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +regulation of apoptotic signaling pathway +release of cytochrome c from mitochondria +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductioncell surface receptor signaling pathwayapolipoprotein A-I-mediated signaling pathwayCD40 signaling pathway +cell surface bile acid receptor signaling pathwaycell surface receptor signaling pathway involved in heart development +collagen-activated signaling pathway +cytokine-mediated signaling pathway +enzyme linked receptor protein signaling pathway +extrinsic apoptotic signaling pathway [GO:0097191] (74 genes, 98 annotations)death-inducing signaling complex assemblyextrinsic apoptotic signaling pathway in absence of ligand +extrinsic apoptotic signaling pathway via death domain receptors +negative regulation of extrinsic apoptotic signaling pathway +positive regulation of extrinsic apoptotic signaling pathway +regulation of extrinsic apoptotic signaling pathway +ripoptosome assembly involved in extrinsic apoptotic signaling pathwayFas signaling pathway +G-protein coupled receptor signaling pathway +glutamate receptor signaling pathway +immune response-regulating cell surface receptor signaling pathway +integrin-mediated signaling pathway +lipopolysaccharide-mediated signaling pathway +netrin-activated signaling pathwayneurotrophin signaling pathway +Notch signaling pathway +peptidoglycan recognition protein signaling pathway +positive regulation of integrin activation by cell surface receptor linked signal transductionpurinergic receptor signaling pathway +reelin-mediated signaling pathwayRoundabout signaling pathway +semaphorin-plexin signaling pathway +smoothened signaling pathway +Toll signaling pathway +Wnt receptor signaling pathway +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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