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Gene Ontology Browser
Term Detail
GO term:extrinsic apoptotic signaling pathway
Synonym: death receptor-mediated apoptosis
Synonym: extrinsic apoptosis
Synonym: extrinsic apoptotic pathway
Synonym: extrinsic apoptotic signaling pathway in presence of ligand
Synonym: extrinsic apoptotic signalling pathway
GO id:GO:0097191
Definition:A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
CommentsFas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
Number of paths to term: 21

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aanti-Mullerian hormone signaling pathway +
                                                        is-aapolipoprotein A-I-mediated signaling pathway
                                                        is-aCD40 signaling pathway +
                                                        is-acell surface bile acid receptor signaling pathway
                                                        is-acell surface receptor signaling pathway involved in heart development +
                                                        is-acollagen-activated signaling pathway +
                                                        is-acytokine-mediated signaling pathway +
                                                        is-aenzyme linked receptor protein signaling pathway +
                                                        is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                        is-aFas signaling pathway +
                                                        is-aG-protein coupled receptor signaling pathway +
                                                        is-aglutamate receptor signaling pathway +
                                                        is-aimmune response-regulating cell surface receptor signaling pathway +
                                                        is-aintegrin-mediated signaling pathway +
                                                        is-alipopolysaccharide-mediated signaling pathway +
                                                        is-anetrin-activated signaling pathway +
                                                        is-aneuropilin signaling pathway +
                                                        is-aneurotrophin signaling pathway +
                                                        is-aNotch signaling pathway +
                                                        is-apeptidoglycan recognition protein signaling pathway +
                                                        is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                        is-apurinergic receptor signaling pathway +
                                                        is-areelin-mediated signaling pathway
                                                        is-aRoundabout signaling pathway +
                                                        is-asemaphorin-plexin signaling pathway +
                                                        is-asmoothened signaling pathway +
                                                        is-aToll signaling pathway +
                                                        is-aurokinase plasminogen activator signaling pathway
                                                        is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway +
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway +
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aanti-Mullerian hormone signaling pathway +
                                                        is-aapolipoprotein A-I-mediated signaling pathway
                                                        is-aCD40 signaling pathway +
                                                        is-acell surface bile acid receptor signaling pathway
                                                        is-acell surface receptor signaling pathway involved in heart development +
                                                        is-acollagen-activated signaling pathway +
                                                        is-acytokine-mediated signaling pathway +
                                                        is-aenzyme linked receptor protein signaling pathway +
                                                        is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                        is-aFas signaling pathway +
                                                        is-aG-protein coupled receptor signaling pathway +
                                                        is-aglutamate receptor signaling pathway +
                                                        is-aimmune response-regulating cell surface receptor signaling pathway +
                                                        is-aintegrin-mediated signaling pathway +
                                                        is-alipopolysaccharide-mediated signaling pathway +
                                                        is-anetrin-activated signaling pathway +
                                                        is-aneuropilin signaling pathway +
                                                        is-aneurotrophin signaling pathway +
                                                        is-aNotch signaling pathway +
                                                        is-apeptidoglycan recognition protein signaling pathway +
                                                        is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                        is-apurinergic receptor signaling pathway +
                                                        is-areelin-mediated signaling pathway
                                                        is-aRoundabout signaling pathway +
                                                        is-asemaphorin-plexin signaling pathway +
                                                        is-asmoothened signaling pathway +
                                                        is-aToll signaling pathway +
                                                        is-aurokinase plasminogen activator signaling pathway
                                                        is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                        is-aB cell receptor apoptotic signaling pathway
                                                                        part-ofdeath-inducing signaling complex assembly +
                                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway +
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway +
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway +
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                        is-aB cell receptor apoptotic signaling pathway
                                                                        part-ofdeath-inducing signaling complex assembly +
                                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                part-ofapoptosome assembly
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-agranzyme-mediated apoptotic signaling pathway
                                                is-ahormone-mediated apoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway +
                                                part-ofmitochondrial outer membrane permeabilization +
                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                regulatesregulation of apoptotic signaling pathway +
                                                part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                        is-aB cell receptor apoptotic signaling pathway
                                                        part-ofdeath-inducing signaling complex assembly +
                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway +
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        part-ofapoptosome assembly
                                                        is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                        is-agranzyme-mediated apoptotic signaling pathway
                                                        is-ahormone-mediated apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway +
                                                        part-ofmitochondrial outer membrane permeabilization +
                                                        negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of apoptotic signaling pathway +
                                                        part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                        regulatesregulation of apoptotic signaling pathway +
                                                        part-ofrelease of cytochrome c from mitochondria +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aanti-Mullerian hormone signaling pathway +
                                                        is-aapolipoprotein A-I-mediated signaling pathway
                                                        is-aCD40 signaling pathway +
                                                        is-acell surface bile acid receptor signaling pathway
                                                        is-acell surface receptor signaling pathway involved in heart development +
                                                        is-acollagen-activated signaling pathway +
                                                        is-acytokine-mediated signaling pathway +
                                                        is-aenzyme linked receptor protein signaling pathway +
                                                        is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                is-aB cell receptor apoptotic signaling pathway
                                                                part-ofdeath-inducing signaling complex assembly +
                                                                is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                        is-aFas signaling pathway +
                                                        is-aG-protein coupled receptor signaling pathway +
                                                        is-aglutamate receptor signaling pathway +
                                                        is-aimmune response-regulating cell surface receptor signaling pathway +
                                                        is-aintegrin-mediated signaling pathway +
                                                        is-alipopolysaccharide-mediated signaling pathway +
                                                        is-anetrin-activated signaling pathway +
                                                        is-aneuropilin signaling pathway +
                                                        is-aneurotrophin signaling pathway +
                                                        is-aNotch signaling pathway +
                                                        is-apeptidoglycan recognition protein signaling pathway +
                                                        is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                        is-apurinergic receptor signaling pathway +
                                                        is-areelin-mediated signaling pathway
                                                        is-aRoundabout signaling pathway +
                                                        is-asemaphorin-plexin signaling pathway +
                                                        is-asmoothened signaling pathway +
                                                        is-aToll signaling pathway +
                                                        is-aurokinase plasminogen activator signaling pathway
                                                        is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                part-ofapoptosome assembly
                                                                is-aextrinsic apoptotic signaling pathway [GO:0097191] (223 genes, 321 annotations)
                                                                        is-aB cell receptor apoptotic signaling pathway
                                                                        part-ofdeath-inducing signaling complex assembly +
                                                                        is-aextrinsic apoptotic signaling pathway in absence of ligand +
                                                                        is-aextrinsic apoptotic signaling pathway via death domain receptors +
                                                                        is-afibroblast growth factor receptor apoptotic signaling pathway
                                                                        negatively-regulatesnegative regulation of extrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of extrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of extrinsic apoptotic signaling pathway +
                                                                        part-ofripoptosome assembly involved in extrinsic apoptotic signaling pathway
                                                                is-agranzyme-mediated apoptotic signaling pathway
                                                                is-ahormone-mediated apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway +
                                                                part-ofmitochondrial outer membrane permeabilization +
                                                                negatively-regulatesnegative regulation of apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of apoptotic signaling pathway +
                                                                part-ofprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway +
                                                                regulatesregulation of apoptotic signaling pathway +
                                                                part-ofrelease of cytochrome c from mitochondria +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory