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All mouse models of lung disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | pulmonary alveolar proteinosis | Abca3tm1Frm/Abca3tm1Frm | involves: 129S/SvEv | J:120296 | View | |||
| pulmonary alveolar proteinosis | Abca3tm1Holz/Abca3tm1Holz | involves: 129S6/SvEvTac * C57BL/6 | J:122736 | View | ||||
| pulmonary alveolar proteinosis | Abca3tm1Nina/Abca3tm1Nina | involves: 129P2/OlaHsd * C57BL/6J | J:121155 | View | ||||
| pulmonary alveolar proteinosis | Csf2tm1Ard/Csf2tm1Ard | involves: 129P2/OlaHsd * C57BL/6 | J:18747 | View | ||||
| pulmonary alveolar proteinosis | Csf2tm1Mlg/Csf2tm1Mlg | involves: 129S2/SvPas | J:17978 | View | ||||
| pulmonary alveolar proteinosis | Csf2raem1Szut/Csf2raem1Szut | C57BL/6-Csf2raem1Szut | J:322934 | View | ||||
| pulmonary alveolar proteinosis | Csf2rbtm1Mur/Csf2rbtm1Mur | involves: 129P2/OlaHsd | J:24122 | View | ||||
| pulmonary alveolar proteinosis | Csf2rbtm1Mur/Csf2rbtm1Mur | involves: 129P2/OlaHsd * C57BL/6 | J:35829 | View | ||||
| | desquamative interstitial pneumonia | Sftpctm1Swg/Sftpctm1Swg | either: 129 or (involves: 129 * Black Swiss) | J:82925 | View | |||
| idiopathic pulmonary fibrosis | Tg(H2-K-Fosl2,-EGFP)13Wag/0 | either: 129.Cg-Tg(H2-K-Fosl2,-EGFP)13Wag or B6.Cg-Tg(H2-K-Fosl2,-EGFP)13Wag | J:139032 | View | ||||
| idiopathic pulmonary fibrosis | Tg(SFTPC-Tnf)2Pva/0 | involves: C57BL/6 * DBA/2 | J:28120 | View | ||||
| lung cancer |
Cdk6tm1Bbd/Cdk6tm1Bbd Krastm1Bbd/Kras+ Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd |
involves: 129S1/Sv * 129X1/SvJ | J:161780 | View | ||||
| lung cancer |
Cdkn2atm4Rdp/Cdkn2atm4Rdp Krastm4Tyj/Kras+ |
involves: 129S4/SvJae | J:195492 | View | ||||
| lung cancer |
Foxm1tm1Rhc/Foxm1tm1Rhc Tg(Tek-cre)1Ywa/0 |
involves: 129X1/SvJ * C57BL/6 * SJL | J:167773 | View | ||||
| lung cancer |
Gadd45atm1Ajf/Gadd45atm1Ajf Xpctm1Ecf/Xpctm1Ecf |
either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129X1/SvJ * C57BL/6) | J:101421 | View | ||||
| lung cancer | Krastm1Bbd/Kras+ | involves: 129S1/Sv * 129X1/SvJ | J:172200 | View | ||||
| lung cancer |
Krastm1Bbd/Kras+ Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd |
involves: 129S1/Sv * 129X1/SvJ | J:161780 | View | ||||
| lung cancer |
Krastm1Bbd/Krastm2Bbd Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd |
involves: 129S1/Sv * 129X1/SvJ | J:161780 | View | ||||
| lung cancer | Krastm2Tyj/Kras+ | involves: 129S2/SvPas | J:68981, J:136369 | View | ||||
| lung cancer | Krastm2Tyj/Kras+ | involves: 129S2/SvPas * C57BL/6 | J:68981 | View | ||||
| lung cancer |
Krastm2Tyj/Kras+ Trp53tm1Glo/Trp53+ |
involves: 129S2/SvPas * 129S7/SvEvBrd | J:129627 | View | ||||
| lung cancer | Krastm3Tyj/Kras+ | involves: 129S4/SvJae | J:68981 | View | ||||
| lung cancer | Krastm3Tyj/Kras+ | involves: 129S4/SvJae * C57BL/6 | J:68981 | View | ||||
| lung cancer | Krastm4Tyj/Kras+ | involves: 129S4/SvJae | J:207982 | View | ||||
| lung cancer | Krastm4Tyj/Kras+ | involves: 129S4/SvJae * C57BL/6 | J:203686 | View | ||||
| lung cancer |
Krastm4Tyj/Kras+ Scribtm1.1Phum/Scrib+ |
involves: 129S4/SvJae | J:216266 | View | ||||
| lung cancer |
Krastm4Tyj/Kras+ Scribtm1.1Phum/Scribtm1.1Phum |
involves: 129S4/SvJae | J:216266 | View | ||||
| lung cancer |
Krastm4Tyj/Kras+ Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm |
B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm | J:177379 | View | ||||
| lung cancer |
Krastm4Tyj/Kras+ Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJae | J:103407, J:154041, J:195492, J:203686 | View | ||||
| lung cancer |
Krastm4Tyj/Kras+ Trp53tm1Lejo/Trp53tm1Lejo |
involves: 129S4/SvJae | J:187012 | View | ||||
| lung cancer |
Krastm4Tyj/Kras+ Trp53tm2Tyj/Trp53+ |
involves: 129S4/SvJae | J:191425 | View | ||||
| lung cancer | Krastm5Tyj/Kras+ | involves: 129S4/SvJae * C57BL/6 | J:172206 | View | ||||
| lung cancer | Robo1tm1Phr/Robo1+ | involves: 129P2/OlaHsd * C57BL/6 | J:93666 | View | ||||
| lung cancer |
Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-Fgf9,-EGFP)#Dor/0 |
involves: FVB | J:204282 | View | ||||
| lung cancer | Xpctm1Ecf/Xpctm1Ecf | involves: 129 * C57BL/6 | J:101421 | View | ||||
| meconium aspiration syndrome | Atf2tm1Sis/Atf2tm1Sis | either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR) | J:55657 | View | ||||
| newborn respiratory distress syndrome | Epas1tm1Pec/Epas1tm1Pec | involves: 129/Sv * Swiss | J:77480 | View | ||||
| newborn respiratory distress syndrome | Ndst1tm1Ekf/Ndst1tm1Ekf | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:63996 | View | ||||
| newborn respiratory distress syndrome | Ndst1tm1Hgx/Ndst1tm1Hgx | involves: 129S4/SvJae * C57BL/6 | J:60280 | View | ||||
| newborn respiratory distress syndrome | Vegfatm1Pec/Vegfatm1Pec | involves: 129S1/Sv * 129X1/SvJ | J:77480 | View | ||||
| pleuropulmonary blastoma |
Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-Fgf9,-EGFP)#Dor/0 |
involves: FVB | J:224791 | View | ||||
| pleuropulmonary blastoma |
Yy1tm2.1Yshi/Yy1tm2.1Yshi Tg(Nkx2-1-cre)2Sand/0 |
involves: 129S4/SvJae * C57BL/6J | J:239777 | View | ||||
| pulmonary emphysema | Bloc1s6pa/Bloc1s6pa | B6.Cg-Bloc1s6pa/J | J:4098 | View | ||||
| pulmonary emphysema | Fstl1tm1Ajn/Fstl1tm1Ajn | B6.Cg-Fstl1tm1Ajn | J:322116 | View | ||||
| pulmonary emphysema | Fut8tm1Nta/Fut8tm1Nta | involves: 129S2/SvPas | J:102932 | View | ||||
| pulmonary emphysema |
Gli2tm1(cre/ERT2)Tipe/Gli2+ Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ |
involves: 129X1/SvJ | J:264185 | View | ||||
| pulmonary emphysema | Itgb6tm1Des/Itgb6tm1Des | involves: 129T2/SvEms | J:89578 | View | ||||
| pulmonary emphysema |
Juntm4Wag/Juntm4Wag Tg(Sftpc-cre)1Blh/0 |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 | J:179883 | View | ||||
| pulmonary emphysema | Klkl/Klkl | either: C.Cg-Klkl or (involves: C3H/HeJ * C57BL/6J) | J:44109 | View | ||||
| pulmonary emphysema | Mus81tm1Esse/Mus81tm1Esse | involves: 129P2/OlaHsd * C57BL/6J | J:222498 | View | ||||
| pulmonary emphysema | Tg(Actb-Ptma)T12Clwu/0 | involves: FVB/N | J:270215 | View | ||||
| pulmonary emphysema | Tg(Actb-Ptma)T12Clwu/Tg(Actb-Ptma)T12Clwu | involves: FVB/N | J:270215 | View | ||||
| pulmonary emphysema | Tlr4tm1Aki/Tlr4tm1Aki | B6.129P2-Tlr4tm1Aki | J:114985 | View | ||||
| | pulmonary emphysema |
Fbn1Tsk/Fbn1+ Tgfb1tm1N/Tgfb1+ |
involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2 | J:68448 | View | |||
| pulmonary emphysema | Serpina1em1Chmu/Serpina1em1Chmu | involves: C57BL/6J | J:259615 | View | ||||
| pulmonary emphysema | Serpina1em2Chmu/Serpina1em2Chmu | involves: C57BL/6J | J:259615 | View | ||||
| pulmonary emphysema | Serpina1em3Chmu/Serpina1em3Chmu | involves: C57BL/6J | J:259615 | View | ||||
| pulmonary emphysema | Serpina1em#Chmu/Serpina1em#Chmu | involves: C57BL/6J | J:259615 | View | ||||
| Transgenes and Other Mutations | adenosquamous lung carcinoma |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-ERBB2*)5BKkw/0 |
involves: FVB/N | J:143874 | View | |||
| adenosquamous lung carcinoma |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-ERBB2*)26Kkw/0 |
involves: FVB/N | J:143874 | View | ||||
| lung adenocarcinoma |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-Kras2)12Hev/0 |
involves: 129 * C57BL/6 * FVB/N | J:73468 | View | ||||
| lung adenocarcinoma | Tg(SFTPC-env)1Yhch/0 | FVB/N-Tg(SFTPC-env)1Yhch | J:247986 | View | ||||
| lung benign neoplasm |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0 |
involves: FVB/N | J:102839 | View | ||||
| lung benign neoplasm |
Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO/CMV-KRAS*G12C)9.1Msmi/0 |
involves: FVB/N | J:102839 | View | ||||
| lung cancer | Tg(ACTB-KRAS*G12V,-luc)#Lche/0 | involves: C57BL/6 * FVB/N | J:199528 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-EGFR*)#Kkw/0 |
involves: 129 * C57BL/6 * FVB/N | J:156440, J:235747 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-EGFR*delta19)11Hev/0 |
involves: C57BL/6 * CBA | J:109092 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-EGFR*L858R)56Hev/0 |
involves: C57BL/6 * CBA | J:109092 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-EGFR*L858R)57Hev/0 |
involves: C57BL/6 * CBA | J:109092 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-EGFR*L858R)#Hev/0 |
involves: 129 * C57BL/6 * CBA | J:128700, J:213447 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-EGFR*T790M)8Paow/0 |
involves: 129 * C57BL/6 * FVB/N | J:128700 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-EGFR*T790M*L858R)19Kkw/0 |
involves: 129 * C57BL/6 * FVB/N | J:122849, J:156440, J:235747 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-EGFR*T790M*L858R)51Paow/0 |
involves: 129 * C57BL/6 * FVB/N | J:128700 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-IGF1R)1Ramo/0 |
involves: 129 * C57BL/6 * FVB | J:271820 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-PIK3CA*H1047R)13Lca/0 |
involves: 129 * C57BL/6 * FVB/N | J:142254 | View | ||||
| lung cancer |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-PTPN11*E76K)#Jiwu/0 |
involves: 129 * C57BL/6 * FVB/N | J:212505 | View | ||||
| lung cancer | Tg(SFTPC-CD74/ROS1)125Tno/0 | C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno | J:231770 | View | ||||
| lung cancer | Tg(SFTPC-EGFR*L858R)4-3Kkiu/0 | involves: C57BL/6Cr | J:152157 | View | ||||
| lung cancer | Tg(SFTPC-EML4/ALK)502-4Hima/0 | involves: C57BL/6J | J:142679 | View | ||||
| lung cancer | Tg(SFTPC-env)1Yhch/0 | FVB/N-Tg(SFTPC-env)1Yhch | J:153538 | View | ||||
| lung cancer | Tg(SFTPC-EZR/ROS1)AShiba/0 | C57BL/6-Tg(SFTPC-EZR/ROS1)AShiba | J:199415 | View | ||||
| lung cancer | Tg(SFTPC-KIF5B/RET)1Tkoh/0 | involves: C57BL/6J | J:215989 | View | ||||
| lung cancer |
Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-IGF1R)1Ramo/0 |
involves: FVB | J:271820 | View | ||||
| lung cancer | Tg(SFTPC-SDC4/ROS1)141Tno/0 | C57BL/6J-Tg(SFTPC-SDC4/ROS1)141Tno | J:231770 | View | ||||
| lung cancer | Tg(Utg-TAg)7593Fjd/? | involves: FVB | J:70785 | View | ||||
| lung cancer | Tg(Utg-TAg)7736Fjd/? | involves: FVB | J:70785 | View | ||||
| lung cancer | Tg(Utg-TAg)#Fjd/? | involves: FVB | J:70785 | View | ||||
| pulmonary emphysema | Tg(HP-MMP1a)34-1Cha/0 | involves: C57BL/6J * CBA/J | J:164058 | View | ||||
| pulmonary emphysema | Tg(HP-MMP1a)34-1Cha/Tg(HP-MMP1a)34-1Cha | involves: C57BL/6J * CBA/J | J:164058 | View | ||||
| pulmonary emphysema | Tg(Msr1-MMP9)#Apar/0 | B6.Cg-Tg(Msr1-MMP9)#Apar | J:136830 | View | ||||
| pulmonary emphysema |
Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-PLAGL2)P3Ysy/0 |
involves: FVB/N | J:152422 | View | ||||
| pulmonary fibrosis |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-TGFA)22.1Kor/0 |
involves: 129 * C57BL/6 * FVB/NJ | J:240947 | View | ||||
| Additional Complex Models | lung cancer | Col1a1tm1(CAG-EGFR*T790M*C797S*L858R)Mje/Col1a1+ | involves: 129S4/SvJae * BALB/c * C57BL/6 | J:235747 | View | |||
| lung cancer |
Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+ Tg(Scgb1a1-rtTA)1Jaw/0 |
involves: 129 * C57BL/6 | J:166724 | View | ||||
| lung cancer | Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+ | involves: 129S4/SvJae * BALB/c * C57BL/6 | J:214230 | View | ||||
| lung cancer |
Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+ Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 | J:214230 | View | ||||
| lung cancer |
Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+ Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 | J:214230 | View | ||||
| lung cancer |
Ctnnb1tm1Mmt/Ctnnb1+ Fgfr3tm4Cxd/Fgfr3+ Tg(Upk2-cre)6Xrw/0 |
involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N | J:174242 | View | ||||
| lung non-small cell carcinoma |
Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+ Tg(Scgb1a1-rtTA)1Jaw/0 |
involves: 129 * C57BL/6 | J:166724 | View | ||||
| lung non-small cell carcinoma |
Krastm4Tyj/Kras+ Stk11tm1.1Rdp/Stk11tm1.1Rdp |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N | J:124682 | View | ||||
| lung non-small cell carcinoma |
Krastm4Tyj/Kras+ Stk11tm1.1Rdp/Stk11tm1.2Rdp |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N | J:124682 | View | ||||
| lung small cell carcinoma |
Rb1tm2Brn/Rb1tm2Brn Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd | J:86077, J:157319 | View | ||||
| lung small cell carcinoma |
Rb1tm2Brn/Rb1tm2Brn Trp53tm1Lejo/Trp53tm1Lejo |
involves: 129 | J:187012 | View | ||||
| lung small cell carcinoma |
Rb1tm3Tyj/Rb1tm3Tyj Rbl2tm2Tyj/Rbl2tm2Tyj Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJae | J:160148 | View | ||||
| lung small cell carcinoma |
Rb1tm3Tyj/Rb1tm3Tyj Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJae | J:160148 | View | ||||
| lung squamous cell carcinoma |
Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:234268 | View | ||||
| pulmonary emphysema | Fbn1Tsk/Fbn1+ | B6.Cg-Fbn1Tsk | J:30961, J:6566, J:15018, J:1326, J:68448 | View | ||||
| pulmonary emphysema |
Fbn1Tsk/Fbn1+ Il4ratm1Sz/Il4ra+ |
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 | J:68448 | View | ||||
| pulmonary emphysema |
Fbn1Tsk/Fbn1+ Il4ratm1Sz/Il4ratm1Sz |
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2 | J:68448 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | chronic obstructive pulmonary disease | Htr4tm1Comp/Htr4tm1Comp | B6.129S1(129T)-Htr4tm1Comp | J:261502 | View | |||
| pulmonary emphysema |
Itgb6tm1Des/Itgb6tm1Des Mmp12tm1Sds/Mmp12tm1Sds |
involves: 129/Sv * 129T2/SvEms | J:89578 | View | ||||