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Transgene Detail
Symbol: Tg(Scgb1a1-rtTA)1Jaw
Name: transgene insertion 1, Jeffrey A Whitsett
MGI ID: MGI:2445707
Synonyms: CC10-rtTA, CCSP-rtTA, CCSPtg, Scgb1a1-rtTA, Tg(Ugb-rtTA)1Jaw
Transgene: Tg(Scgb1a1-rtTA)1Jaw  Location: unknown  
Alliance: Tg(Scgb1a1-rtTA)1Jaw page
Absence of proliferation during goblet cell hyperplasia in Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-Spdef)1Jaw/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  129 and C57BL/6
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
Mutation detailsThe transgene is composed of 2.3 kb of rat Ugb (Scgb1a1) promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and 2 kb of human growth hormone sequences, which includes introns and a polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The rat Scgb1a1 promoter is active in respiratory epithelial cells. (J:61736)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Tg(Scgb1a1-rtTA)1Jaw
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523, J:171488).
Original:  J:61736 Tichelaar JW, et al., Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem. 2000 Apr 21;275(16):11858-64
All:  217 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory