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Targeted Allele Detail
Symbol: Yy1tm2.1Yshi
Name: YY1 transcription factor; targeted mutation 2.1, Yang Shi
MGI ID: MGI:3624790
Synonyms: yy1f
Gene: Yy1  Location: Chr12:108758899-108786074 bp, + strand  Genetic Position: Chr12, 59.58 cM
Alliance: Yy1tm2.1Yshi page
Skin and hair pigmentation phenotype of Yy1tm2.1Yshi/Yy1tm2.1Yshi Tg(Tyr-cre)1Lru/Y mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:108369
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 1 and the promoter region were flanked with loxP sites by homologous recombination. The FRT-flanked neomycin cassette inserted downstream of the 3' loxP site was removed by Flp mediated recombination. Protein expression is similar to wild-type. (J:108369)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 76 assay results
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Yy1 Mutation:  23 strains or lines available
Original:  J:108369 Affar el B, et al., Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol. 2006 May;26(9):3565-81
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory