Col1a1^{tm1(CAG-EGFR*T790M*C797S*L858R)Mje}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(CAG-EGFR*T790M*C797S*L858R)Mje}
• Name: collagen, type I, alpha 1; targeted mutation 1, Michael J Eck
• MGI ID: MGI:6256800
• Synonyms: LSL-EGFR T790M/L858R/C797S, TLCS
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(CAG-EGFR*T790M*C797S*L858R)Mje} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235747
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Col1a1^{tm1(CAG-EGFR*T790M*C797S*L858R)Mje} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

• Mutation details: The CAG promotor, a loxP-flanked STOP cassette (LSL) and the human EGFR cDNA with the L858R, the T790M, and the C797S mutations were inserted into the locus. Upon cre-mediated recombination, the STOP cassette is excised promoting expression of the mutant EGFR. (J:235747)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 160 strains or lines available

References

• Original: J:235747 Jia Y, et al., Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature. 2016 Jun 2;534(7605):129-32
• All: 1 reference(s)