Atf2^tm1Sis
Targeted Allele Detail

Summary

• Symbol: Atf2^tm1Sis
• Name: activating transcription factor 2; targeted mutation 1, Shunsuke Ishii
• MGI ID: MGI:3842320
• Synonyms: ATF-2^o
• Gene: Atf2 Location: Chr2:73646853-73722983 bp, - strand Genetic Position: Chr2, 43.86 cM
• Alliance: Atf2^tm1Sis page

Respiration defects of the Atf2^tm1Glm/Atf2^tm1Glm mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55657
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into the exon (amino acids 327-395) that encodes the DNA-binding domain consisting of the basic amino acid region between amino acids 378 and 379. Western blot analysis confirmed absence of protein. (J:55657)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atf2 Mutation: 89 strains or lines available

References

• Original: J:55657 Maekawa T, et al., Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. J Biol Chem. 1999 Jun 18;274(25):17813-9
• All: 2 reference(s)