Phenotypes Associated with This Genotype

Genotype
MGI:7256886

• Allelic Composition: Fstl1^tm1Ajn/Fstl1^tm1Ajn
• Genetic Background: B6.Cg-Fstl1^tm1Ajn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal respiratory system physiology ( J:322116 )

• mice exhibit decreased tissue resistance

• pressure-volume loops show a leftward/upward deflection indicating emphysematous lung physiology

increased lung apoptosis ( J:322116 )

• distinct lung immune cell populations show increased apoptosis, including CD11b+/CD11c+ and CD11b+/CD11c- cells, but not alveolar macrophages (CD11b-/CD11c+/SiglecF+)

• however, no differences in apoptosis is seen in endothelial, epithelial, or mesenchymal cells

emphysema ( J:322116 )

• mice develop histologic (increased airspace size), functional, and radiographic finding consistent with pulmonary emphysema, independent of chronic cigarette smoke exposure

• the emphysema seen in mice is not exacerbated by exposure to chronic cigarette smoke

decreased lung elastance ( J:322116 )

abnormal lung hysteresivity ( J:322116 )

• mice exhibit decreased lung hysteresis

abnormal lung volume ( J:322116 )

• mice show increased lung volumes and decreased lung density

increased lung compliance ( J:322116 )

cellular

increased lung apoptosis ( J:322116 )

• distinct lung immune cell populations show increased apoptosis, including CD11b+/CD11c+ and CD11b+/CD11c- cells, but not alveolar macrophages (CD11b-/CD11c+/SiglecF+)

• however, no differences in apoptosis is seen in endothelial, epithelial, or mesenchymal cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary emphysema		DOID:9675	OMIM:130700	J:322116