Sftpc^tm1.1Xft
Targeted Allele Detail

Summary

• Symbol: Sftpc^tm1.1Xft
• Name: surfactant associated protein C; targeted mutation 1.1, Xiaofang Tang
• MGI ID: MGI:8273429
• Synonyms: Sftpc^I73T
• Gene: Sftpc Location: Chr14:70758389-70761521 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Sftpc^tm1.1Xft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:376785
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details:

  A full-length mouse cDNA including the I73T (218 T to C) mutation was introduced in-frame in exon 1 and a floxed neo cassette was inserted into intron 1 via homologous recombination. Cre-mediated recombination removed the neo cassette. (J:376785)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sftpc Mutation: 27 strains or lines available

References

• Original: J:376785 Tang X, et al., EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease. J Clin Invest. 2024 Oct 15;134(23)
• All: 1 reference(s)