All Phenotypes Sftpc<tm1.1Xft> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sftpc^tm1.1Xft
targeted mutation 1.1, Xiaofang Tang
MGI:8273429

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sftpc^tm1.1Xft/Sftpc^tm1.1Xft	involves: C57BL/6J	MGI:8405102
ht2	Sftpc^tm1.1Xft/Sftpc⁺	Not Specified	MGI:8405103
ht3	Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap}	involves: 129 * C57BL/6 * C57BL/6J	MGI:8405106
cn4	Emc3^{tm1c(EUCOMM)Wtsi}/Emc3^{tm1c(EUCOMM)Wtsi} Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap}	involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N	MGI:8405107

Allelic Composition	Sftpc^tm1.1Xft/Sftpc^tm1.1Xft
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpc^tm1.1Xft mutation (0 available); any Sftpc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal pulmonary alveolus morphology ( J:376785 )

• mice exhibit simplified alveoli (focal airspace enlargement) as early as P7 in the peripheral lung

• treatment with the VCP inhibitor, CB5083, improves alveolar morphology without causing overt toxicity

• however, no obvious fibrosis is seen in the lungs and autophagy and ER stress are not altered in alveolar 2 epithelial cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
interstitial lung disease		DOID:3082	OMIM:PS619611	J:376785

Allelic Composition	Sftpc^tm1.1Xft/Sftpc⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpc^tm1.1Xft mutation (0 available); any Sftpc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal pulmonary alveolus morphology ( J:376785 )

• mice exhibit subtle airspace enlargement (simplified alveoli)

Allelic Composition	Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap}
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sftpc^tm1.1Xft mutation (0 available); any Sftpc mutation (27 available)
Sftpc^{tm1(cre/ERT2,rtTA)Hap} mutation (0 available); any Sftpc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal pulmonary alveolus morphology ( J:376785 )

• mice exhibit alveolar simplification on P21

abnormal type II pneumocyte morphology ( J:376785 )

• alveolar 2 epithelial cells from tamoxifen-treated mice contain more mitochondria close to the cell surface than in controls

cellular

abnormal mitochondrial physiology ( J:376785 )

• maximal respiration capacity of alveolar 2 epithelial cells cell mitochondria is decreased and alveolar 2 epithelial cells show reduced glycolysis, glycolytic capacity, and glycolytic reserve, indicating mitochondrial dysfunction

• however, no differences in basal respiration are detected by oxygen consumption

Allelic Composition	Emc3^{tm1c(EUCOMM)Wtsi}/Emc3^{tm1c(EUCOMM)Wtsi} Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap}
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emc3^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Emc3 mutation (16 available)
Sftpc^tm1.1Xft mutation (0 available); any Sftpc mutation (27 available)
Sftpc^{tm1(cre/ERT2,rtTA)Hap} mutation (0 available); any Sftpc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:376785 )

N	• tamoxifen-treated adult mice show restoration of the decreased maximal respiration capacity of alveolar 2 epithelial cells cell mitochondria and improved glycolytic capacity that is seen in single mutant Sftpc mice

enlarged alveolar lamellar bodies ( J:376785 )

• tamoxifen-treated mice show enlarged lamellar body morphology in alveolar 2 epithelial cells

respiratory system

respiratory system phenotype ( J:376785 )

N	• tamoxifen-treated mice show restoration of the lung morphology seen in single mutant Sftpc mice, with rescue of the alveolar simplification in neonatal mice and in adult tamoxifen-treated mice

enlarged alveolar lamellar bodies ( J:376785 )

• tamoxifen-treated mice show enlarged lamellar body morphology in alveolar 2 epithelial cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/08/2026 MGI 6.24