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Sftpc Gene Detail
Summary
  • Symbol
    Sftpc
  • Name
    surfactant associated protein C
  • Synonyms
    Bricd6, pro-SpC, Sftp-2, Sftp2, SP-C, SPC
  • Feature Type
    protein coding gene
  • IDs
    MGI:109517
    NCBI Gene: 20389
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70758389-70761521 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109517
 protein coding gene Chr14:70758381-70761521 (-)
129S1/SvImJ ENSMUSG00200028772
 protein coding gene Chr14:59151408-59154546 (-)
A/J ENSMUSG00195013719
 protein coding gene Chr14:59331443-59334610 (-)
AKR/J ENSMUSG00220027830
 protein coding gene Chr14:58667175-58670342 (-)
BALB/cJ ENSMUSG00180030798
 protein coding gene Chr14:58939997-58943164 (-)
C3H/HeJ ENSMUSG00175035572
 protein coding gene Chr14:60700496-60703663 (-)
C57BL/6NJ ENSMUSG00215022933
 protein coding gene Chr14:58876684-58879851 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019484
 protein coding gene Chr14:61627807-61631011 (-)
CAST/EiJ ENSTCUG00005038650
 protein coding gene Chr14:60581815-60584980 (-)
CBA/J ENSMUSG00210036838
 protein coding gene Chr14:59316316-59319483 (-)
DBA/2J ENSMUSG00185022427
 protein coding gene Chr14:64485899-64489066 (-)
FVB/NJ ENSMUSG00205034313
 protein coding gene Chr14:58826602-58829769 (-)
JF1/MsJ ENSUMUG00000039538
 protein coding gene Chr14:75662338-75665476 (-)
LP/J ENSMUSG00230011827
 protein coding gene Chr14:76515154-76518292 (-)
NOD/ShiLtJ ENSMUSG00190035237
 protein coding gene Chr14:59111451-59114618 (-)
NZO/HlLtJ ENSMUSG00225039553
 protein coding gene Chr14:66838279-66841446 (-)
PWK/PhJ ENSLUMG00010035292
 protein coding gene Chr14:58513239-58516395 (-)
SPRET/EiJ ENSMSPG00010023180
 protein coding gene Chr14:62075726-62081696 (-)
WSB/EiJ ENSIUOG00005039115
 protein coding gene Chr14:58554626-58557775 (-)



Homology
more
  • Human Ortholog
    SFTPC, surfactant protein C
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFTPC, surfactant protein C
  • Synonyms
    BRICD6, PSP-C, SFTP2, SMDP2, SP-C
  • Links
    NCBI Gene ID: 6440
    UniProt: P11686

  • Chr Location
    8p21.3; chr8:22156913-22164479 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Sftpc mouse models; 9 with human SFTPC associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 7 alleles in 11 genetic backgrounds
    22 phenotypes from multigenic genotypes
    6 images
    225 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display respiratory abnormalities similar to emphysema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1228
  • Tissues
    69
  • cDNA Data
    909
  • Literature Summary
    402
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022097 Ensembl Gene Model | MGI Sequence Detail 3133 C57BL/6J ±  kb
    transcript ENSMUST00000022692 Ensembl | MGI Sequence Detail 792 Not Applicable  
    polypeptide ENSMUSP00000022692 Ensembl | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 956
      Genomic 1
      cDNA 915
      Primer pair 29
      Other 11
      Antibodies 55

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14378, MGD-MRK-14381, MGD-MRK-39516
    References
    more
    • Summaries
      All 687
      Developmental Gene Expression 402
      Diseases 4
      Gene Ontology 8
      Phenotypes 225
    • Earliest
      J:10878 Glasser SW, et al., Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse. J Biol Chem. 1990 Dec 15;265(35):21986-91
    • Latest
      J:391810 Lv J, et al., Loss of Alkbh5 enhances AT2 cell differentiation and alveolar repair across diverse injury models via m(6)A-dependent Areg signaling. Int J Biol Sci. 2026;22(12):6465-6482
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory